Preformulation and Formulation during Drug Development

Dear Colleagues,

It is well known that approximately 50% of drug candidates going to clinical trials fail primarily due to efficacy and safety issues. The rest may drop due to solubility, drug–drug interaction, and stability issues. In this sense, preformulation and formulation are key factors improving the rate of success during drug development by improving the physicochemical properties as well as pharmacokinetic properties. In addition, preformulation and formulation play important roles in developing incrementally modified drugs by manipulating physicochemical properties or pharmacokinetic properties of drugs or applying various drug delivery systems. With advances in pharmaceutical technology, in many cases, those issues are not a problem anymore. However, it is still challenging to modify the properties as desired.

In this Special Issue, recent advances in improving and modifying the properties of drugs by applying the knowledge of preformulation and formulation will be discussed.

Prof. Dr. Eun Hee Lee
Guest Editor

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