Recent Advances in Radiopharmacy

Dear Colleagues,

Innovative radionuclides, such as astatine-211 and actinium-225 in therapy, or copper-64 and zirconium-89 in imaging, are becoming increasingly important in radiopharmacy. However, it is difficult to develop them for clinical application. The aim of this Special Issue is to establish the potential uses of these innovative radionuclides, to discuss new trends in radiopharmaceuticals developed with them, and to provide a basis to facilitate their use in clinical trials.

This Special Issue aims to present new trends in the use of innovative radionuclides and their applications in radiopharmacy. The physical or chemical properties of new radionuclides are sometimes unfavorable for the stability of the radiopharmaceuticals obtained with them, which limits their applications. Even if these radionuclides are recognized as being of interest by the scientific community, many questions remain to be answered. Is the growing application of actinium [225Ac] radiolabeled peptides, which are characterized by rapid pharmacokinetic distribution and elimination phases, extensible to other vectors currently used in internal radiotherapy? Is radioactive filiation compatible with non-internalized radiopharmaceuticals? What will be the place of [211At]-Astatine, currently studied at the preclinical level? Are the physical properties of [64Cu]-Copper and its particular metabolism interesting compared with [89Zr]-Zirconium? This Special Issue aims to address these questions, in order to elucidate the future applications of these radionuclides in radiopharmacy.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: innovative radionuclides and their associated radiopharmaceuticals, pharmacokinetics models for innovative radionuclides, in vivo and in vitro stability studies of innovative radionuclides, and new vectors for innovative radionuclides. We look forward to receiving your contributions.

Prof. Dr. Alain Faivre-Chauvet
Guest Editor

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