Skin Immunomodulation: Impact on Diseases and Treatments

Dear Colleagues,

One of the skin’s primary functions is to protect our body against the entry and exit of substances. In addition to serving as a mechanical barrier, this protection is possible due to the complex skin immune system. Innate skin immunity activates immunomodulators, such as cytokines, which control inflammatory processes, cell proliferation, and apoptosis, thus preventing the development of skin cancer, inflammatory and autoimmune diseases, and allergies. The skin’s microbiota also play a vital role in this protection, preventing the entry of pathogens and opportunistic infection.

The topical administration of drugs that activate and modulate the skin immune system has been a strategy in treating skin diseases. To prevent the rapid biodegradation of these drugs and to sustain their release in the case of application on exposed wounds, or to enable their transport to viable layers of the skin in cases where the skin barrier is intact or hyperkeratinized, requires drug delivery systems and physical methods, respectively.

The purpose of this Special Issue is to highlight current research on contemporary skin immunomodulation strategies aimed at treating skin diseases. Articles addressing the development of topical formulations that aim to modulate the immune response and skin microbiota, treat skin diseases, and understand their mechanisms on this response are welcome.

Prof. Dr. Renata Fonseca Vianna Lopez
Guest Editor

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