Smart Nanomaterials for Biomedicine

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2740

Special Issue Editor


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Guest Editor
Hansjörg Wyss Institute for Biologically Inspired Engineering at Harvard University, Cambridge, MA 02138, USA
Interests: nanotechnology; smart biomaterials; drug delivery; regenerative medicine; cancer therapy; nanorobotics

Special Issue Information

Dear Colleagues,

The field of nanotechnology is rapidly developing to generate novel solutions for challenges in biomedicine. Smart nanomaterials can be wirelessly activated to perform predetermined tasks in confined spaces and offer unprecedent approaches to therapeutics and diagnostics. Combined with active biomaterials, intelligent material systems have been used to release drugs in a targeted manner, perform in vivo sensing, and kill cancer cells. These pioneering biomedical applications of smart nanomaterials suggest that the field will continue to develop however there are challenges to be overcome for seamless in vivo integration.

In this special issue, we would like to highlight the exciting developments in the field and draw attention to challenges ahead.

Dr. Berna Özkale Edelmann
Guest Editor

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Keywords

  • nanotechnology
  • active biomaterials
  • nanorobotics
  • drug delivery
  • patient based therapeutics
  • theranostics
  • cell delivery
  • sensing
  • cancer therapy

Published Papers (1 paper)

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Review

21 pages, 26250 KiB  
Review
Plasma-Enabled Smart Nanoexosome Platform as Emerging Immunopathogenesis for Clinical Viral Infection
by Seyyed Mojtaba Mousavi, Seyyed Alireza Hashemi, Ahmad Gholami, Masoomeh Yari Kalashgrani, Neralla Vijayakameswara Rao, Navid Omidifar, Wesley Wei-Wen Hsiao, Chin Wei Lai and Wei-Hung Chiang
Pharmaceutics 2022, 14(5), 1054; https://doi.org/10.3390/pharmaceutics14051054 - 13 May 2022
Cited by 16 | Viewed by 2460
Abstract
Smart nanoexosomes are nanosized structures enclosed in lipid bilayers that are structurally similar to the viruses released by a variety of cells, including the cells lining the respiratory system. Of particular importance, the interaction between smart nanoexosomes and viruses can be used to [...] Read more.
Smart nanoexosomes are nanosized structures enclosed in lipid bilayers that are structurally similar to the viruses released by a variety of cells, including the cells lining the respiratory system. Of particular importance, the interaction between smart nanoexosomes and viruses can be used to develop antiviral drugs and vaccines. It is possible that nanoexosomes will be utilized and antibodies will be acquired more successfully for the transmission of an immune response if reconvalescent plasma (CP) is used instead of reconvalescent plasma exosomes (CPExo) in this concept. Convalescent plasma contains billions of smart nanoexosomes capable of transporting a variety of molecules, including proteins, lipids, RNA and DNA among other viral infections. Smart nanoexosomes are released from virus-infected cells and play an important role in mediating communication between infected and uninfected cells. Infections use the formation, production and release of smart nanoexosomes to enhance the infection, transmission and intercellular diffusion of viruses. Cell-free smart nanoexosomes produced by mesenchymal stem cells (MSCs) could also be used as cell-free therapies in certain cases. Smart nanoexosomes produced by mesenchymal stem cells can also promote mitochondrial function and heal lung injury. They can reduce cytokine storms and restore the suppression of host antiviral defenses weakened by viral infections. This study examines the benefits of smart nanoexosomes and their roles in viral transmission, infection, treatment, drug delivery and clinical applications. We also explore some potential future applications for smart nanoexosomes in the treatment of viral infections. Full article
(This article belongs to the Special Issue Smart Nanomaterials for Biomedicine)
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