Applications of Ultrasound and Light in Drug Targeting, Therapy and Diagnosis

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Clinical Pharmaceutics".

Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 2561

Special Issue Editors


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Guest Editor
Department of Physiology, Faculty of Medicine, Jinan University, Guangzhou 510632, China
Interests: ion channels; sonogenetics; optogenetics; diabetes; reproduction

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Guest Editor
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: biophotonics; photoacoustic imaging; photoacoustic microscopy; photothermal therapy
Guangdong Institute of Intelligence Science and Technology, Zhuhai 519031, China
Interests: ultrasound neuromodulation; sonogenetics; optogenetics; photodynamic therapy

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Guest Editor
Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, China
Interests: synergy of light and sound for biomedical applications; photoacoustic imaging; acousto-optic imaging; biophotonics; medical ultrasound; optical wavefront shaping; optogenetics

Special Issue Information

Dear Colleagues,

Ultrasound and light have long been used as essential tools in medical diagnosis via their imaging functions. Recently, they have been promoted as a new modality in drug targeting, therapy, as well as molecular diagnosis due to their excellent safety and high temporal and spatial resolution. Ultrasound and light facilitate drug targeting, including enhancing the efficiency of drug intake or remotely controlling the release of drugs delivered by microbubbles or nanoparticles. Furthermore, ultrasound and light have also been widely applied in therapy, such as cancer therapy and neuromodulation, due to their thermal, mechanical, or chemical effects. Moreover, the application of ultrasound and light in diagnosis has been broadened to the molecular imaging field, due to the improved specificity of modified nanoparticles and microbubbles. In all, application development of ultrasound and light in preclinic and clinic provides more possibilities in disease diagnosis and therapy.

This Special Issue aims to highlight and capture contemporary progress and the current landscape of applications of ultrasound and light in pre-clinics and clinics. We are pleased to invite you submit articles on all aspects of “Application of Ultrasound and light in Drug Targeting, Therapy and Diagnosis”.

In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) the following: ultrasound and light-based drug delivery; application of ultrasound and light on disease therapy; molecular imaging; sonogenetics and optognetics.

Dr. Jinghui Guo
Dr. Yingying Zhou
Dr. Zhihai Qiu
Prof. Dr. Puxiang Lai
Guest Editors

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Keywords

  • drug delivery
  • photodynamic therapy
  • sonodynamic therapy
  • optogenetics
  • sonogenetics
  • molecular imaging
  • cancer diagnosis

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Published Papers (1 paper)

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Research

10 pages, 13017 KiB  
Article
Small Animal In Situ Drug Delivery Effects via Transdermal Microneedles Array versus Intravenous Injection: A Pilot Observation Based on Photoacoustic Tomography
by Yingying Zhou, Xiazi Huang, Jiyu Li, Ting Zhu, Weiran Pang, Larry Chow, Liming Nie, Lei Sun and Puxiang Lai
Pharmaceutics 2022, 14(12), 2689; https://doi.org/10.3390/pharmaceutics14122689 - 1 Dec 2022
Cited by 7 | Viewed by 2043
Abstract
Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation. Transdermal drug delivery overcomes the aforementioned defects, and the microneedles (MNs) [...] Read more.
Intravenous injection is a rapid, low-cost, and direct method that is commonly used to deliver multifarious biotherapeutics and vaccines. However, intravenous injection often causes trauma or tissue injury that requires professional operation. Transdermal drug delivery overcomes the aforementioned defects, and the microneedles (MNs) array is one of the most promising transdermal drug delivery platforms. Timely, precise, and non-invasive monitoring and evaluation of the effects of MNs in transdermal administration is significant to the research of drug efficiency response to specific diseases. In this sense, photoacoustic computed tomography (PACT), which provides wavelength-selective and deep-penetrating optical contrast, could be a promising imaging tool for in situ evaluation of the treatment effects. In this work, we propose the use of PACT to non-invasively assess the effects of real-time drug delivery in glioma tumors through transdermal administration with degradable indocyanine green-loaded hyaluronic acid MNs (ICG-HA-MNs). The outcome is systematically and quantitatively compared with that via intravenous injection. It is found that the photoacoustic signals of ICG in the tumor site express a faster elevation and shorter duration time in the intravenous injection group; by contrast, the photoacoustic signals demonstrate a lower intensity but prolonged duration time in the MNs group. The observed phenomenon indicates faster response but shorter drug duration for intravenous injection, which is in contrast with the lower loading but prolonged performance for transdermal drug delivery with MNs. These results exhibit good consistency with the earlier, common-sense findings reported from other aspects, confirming that PACT can serve as a potential imaging tool to precisely, non-invasively, and quickly evaluate in situ drug delivery effects and provide constructive guidance for the design and fabrication of microneedles. Full article
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