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Polymers
Special Issues
Chitosan in Drug Delivery
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Chitosan in Drug Delivery

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2092

Special Issue Editors

Dr. Florentina Lupascu

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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Medicine and Pharmacy “Grigore T. Popa” Iasi, 16 University Street, 700115 Iasi, Romania
Interests: organic synthesis; chitosan microparticles and nanoparticles; antioxidant activity; diabetes mellitus type 2; drug delivery systems; drug loading; release profile
Special Issues, Collections and Topics in MDPI journals
Dr. Maria Apotrosoaei

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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
Interests: synthesis; 13C-NMR; 1H-NMR; synthetic chemistry; synthetic organic chemistry; heterocyclic chemistry; organic chemistry synthesis; IR; medicinal and pharmaceutical chemistry
Special Issues, Collections and Topics in MDPI journals
Dr. Ioana Mirela Vasincu

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Guest Editor
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Grigore T. Popa University of Medicine and Pharmacy of Iasi, 16 University Street, 700115 Iasi, Romania
Interests: NSAIDs; cyclodextrin inclusion complexes; nanoparticles; antioxidant activity analgesic and anti-inflammatory effects; drug delivery systems
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Drug delivery systems (DDSs) hold an important position in the pharmaceutical field in order to improve the pharmacological properties of free conventional drugs. Chitosan, either alone or as a composite, due to its numerous beneficial properties is extensively researched as a drug carrier for various routes of administration. Its properties are closely related to the type of manufactured carrier (hydrogels, films, membranes, beads, porous foams, micro- and nanoparticles, in situ gels, sponges, nanofibers, etc.). Therefore, chemists, bioengineers, physicists, and materials science specialists targeting the development of new DDSs, are welcome to share their results by publishing in this Special Issue.

Topics of interest for this Special Issue include, yet are not limited to, the following:

  • Design, development, and characterization of chitosan DDSs;
  • Applications of these DDSs and their in vitro and in vivo evaluation;
  • Other topics which highlight the importance of using chitosan in the development of new DDSs to support targeted therapy. 

This Special Issue is addressed to a large number of readers in the materials science field; we encourage the submission of articles for review and later publication.

Dr. Florentina Lupascu
Dr. Maria Apotrosoaei
Dr. Ioana Mirela Vasincu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • chitosan
  • drug delivery systems
  • hydrogels
  • films
  • nanofibers
  • microparticles
  • nanoparticles
  • polymeric materials
  • target drug carriers
  • drugs
  • polymer carriers
  • drug loading

Published Papers (2 papers)

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Research

15 pages, 4349 KiB  
Article
New Chitosan-Based Co-Delivery Nanosystem for Diabetes Mellitus Therapy
by Florentina Geanina Lupascu, Alexandru Sava, Simona-Maria Tătărușanu, Andreea-Teodora Iacob, Andrei Dascălu, Bianca-Ștefania Profire, Ioana-Mirela Vasincu, Maria Apotrosoaei, Tudor-Cătălin Gîscă, Ioana-Andreea Turin-Moleavin and Lenuta Profire
Polymers 2024, 16(13), 1825; https://doi.org/10.3390/polym16131825 - 27 Jun 2024
Viewed by 418
Abstract
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement of oxidative stress in its onset and progression. Pioglitazone (Pio) is an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) is a [...] Read more.
Type 2 diabetes mellitus (T2DM) is one of the most common metabolic disorders, with a major involvement of oxidative stress in its onset and progression. Pioglitazone (Pio) is an antidiabetic drug that mainly works by reducing insulin resistance, while curcumin (Cur) is a powerful antioxidant with an important hypoglycemic effect. Both drugs are associated with several drawbacks, such as reduced bioavailability and a short half-life time (Pio), as well as instability and poor water solubility (Cur), which limit their therapeutic use. In order to overcome these disadvantages, new co-delivery (Pio and Cur) chitosan-based nanoparticles (CS-Pio-Cur NPs) were developed and compared with simple NPs (CS-Pio/CS-Cur NPs). The NPs were characterized using dynamic light scattering (DLS), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Fourier-transform infrared spectroscopy (FTIR). In addition, the entrapment efficiency (EE) and loading capacity (LC), as well as the release profile, of the APIs (Pio and Cur) from the CS-APIs NPs in simulated fluids (SGF, SIF, and SCF) were also assessed. All the CS-APIs NPs presented a small particle size (PS) (211.6–337.4 nm), a proper polydispersity index (PI) (0.104 and 0.289), and a positive zeta potential (ZP) (21.83 mV–32.64 mV). Based on the TEM results, an amorphous state could be attributed to the CA-APIs NPs, and the TEM analysis showed a spherical shape with a nanometric size for the CS-Pio-Cur NPs. The FT-IR spectroscopy supported the successful loading of the APIs into the CS matrix and proved some interactions between the APIs and CS. The CS-Pio-Cur NPs presented increased or similar EE (85.76% ± 4.89 for Cur; 92.16% ± 3.79 for Pio) and LC% (23.40% ± 1.62 for Cur; 10.14% ± 0.98 for Pio) values in comparison with simple NPs, CS-Cur NPs (EE = 82.46% ± 1.74; LC = 22.31% ± 0.94), and CS-Pio NPs (EE = 93.67% ± 0.89; LC = 11.24% ± 0.17), respectively. Finally, based on the release profile results, it can be appreciated that the developed co-delivery nanosystem, CS-Pio-Cur NPs, assures a controlled and prolonged release of Pio and Cur from the polymer matrix along the GI tract. Full article
(This article belongs to the Special Issue Chitosan in Drug Delivery)
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14 pages, 8380 KiB  
Article
pH-Responsive Chitosan-Doped ZnO Hybrid Hydrogels for the Encapsulation of Bioactive Compounds in Aquaculture
by Samuel Sánchez-Serrano, Daniela J. González-Méndez, José A. Olivas-Valdez, Natalie Millán-Aguiñaga, Viridiana Evangelista, Oscar E. Contreras and Marlene N. Cardoza-Contreras
Polymers 2023, 15(20), 4105; https://doi.org/10.3390/polym15204105 - 16 Oct 2023
Viewed by 1070
Abstract
In this study, we synthesized and characterized pH-responsive Chitosan–AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. [...] Read more.
In this study, we synthesized and characterized pH-responsive Chitosan–AgCl-doped ZnO hybrid hydrogels and evaluated their potential for loading aquaculture bioactive compounds, and assessed their antimicrobial properties against a threatening pathogen associated with disease across a broad spectrum of warm water fish and invertebrates. Hydrogel characterization consisted of assessing morphology via SEM, composition via EDS, hydrogels’ network components interactions via FT-IR and pH response through swelling behavior determinations. The swelling characterization of the synthesized hydrogels demonstrated a pH-responsive behavior, showing that low pH values caused the hydrogel polymeric network to expand and capture more of the aqueous solution. These characteristics make the synthesized hydrogels suitable for the encapsulation and controlled release of drugs and bioactive compounds in aquaculture. Chitosan_ZnO hybrid hydrogels showed great antimicrobial activity against Vibrio harveyi, even better than that of loaded PB hydrogels. Here, we provide evidence for the potential capacity of Chitosan_ZnO hybrid hydrogels for the preventive and curative treatment of diseases that impact aquaculture animal health and prevent drug resistance by bacteria. Full article
(This article belongs to the Special Issue Chitosan in Drug Delivery)
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