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Innovative Functional Polymer Composites for Next-Generation Biomedical Solutions

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 682

Special Issue Editor


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Guest Editor
1. Department of Science and Engineering of Oxide Materials and Nanomaterials, National University of Science and Technology Politehnica Bucharest, 011061 Bucharest, Romania
2. Research Institute of the University of Bucharest—ICUB, University of Bucharest, 050657 Bucharest, Romania
Interests: synthesis and characterization of nanobiomaterials; microfluidic synthesis; nanocomposites; biomedical engineering; drug delivery and targeting; antimicrobial surfaces; nanomodified surfaces
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Special Issue Information

Dear Colleagues,

The field of biomedical engineering is undergoing a transformative era, driven by advancements in functional polymer composites. These materials benefit from tunable physicochemical, mechanical, and biological properties that recommend them for diverse biomedical applications, including drug delivery systems, tissue engineering scaffolds, diagnostic devices, and antimicrobial coatings. This Special Issue aims to explore cutting-edge research and innovations in synthesizing, characterizing, and applying polymer composites that are tailored for biomedical purposes. Topics of interest include, but are not limited to, smart stimuli-responsive systems, bioactive polymer blends, nanocomposites for targeted therapies, and biodegradable materials for sustainable healthcare solutions. Submissions related to novel fabrication techniques, innovative functional composites, biocompatibility assessments, and translational research are particularly invited.

We welcome all types of manuscripts, including Research Articles, Reviews, and Short Communications. This Special Issue will provide a comprehensive overview of the state of the art in functional polymer composites and their potential to revolutionize modern medicine.

Dr. Adelina-Gabriela Niculescu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • functional polymer composites
  • biomedical applications
  • tissues engineering
  • drug delivery systems
  • stimuli-responsive polymers
  • biodegradable materials
  • nanocomposites
  • biocompatibility
  • antimicrobial coatings
  • diagnostic devices

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Published Papers (1 paper)

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Research

20 pages, 26470 KB  
Article
Advanced Electrospun Chitosan-(Polylactic Acid)-(Silver Nanoparticle)-Based Scaffolds for Facilitated Healing of Purulent Wounds: A Preclinical Investigation
by Yevhen Samokhin, Yuliia Varava, Anna Butsyk, Roman Moskalenko, Yevheniia Husak, Bohdan Dryhval, Valeriia Korniienko, Ihor Zhyvotovskyi, Vyacheslav Kukurika, Artem Shmatkov, Agne Ramanaviciute, Rafal Banasiuk, Maksym Pogorielov, Arunas Ramanavicius and Viktoriia Korniienko
Polymers 2025, 17(16), 2225; https://doi.org/10.3390/polym17162225 - 15 Aug 2025
Viewed by 518
Abstract
Biomaterials modified by antibacterial substances, including nanoparticles, open new opportunities for the effective treatment of infected wounds. Unfortunately, most publications focused only on experiments in vitro, with limited understanding of their potential for the clinic. This study evaluates the effectiveness in vivo of [...] Read more.
Biomaterials modified by antibacterial substances, including nanoparticles, open new opportunities for the effective treatment of infected wounds. Unfortunately, most publications focused only on experiments in vitro, with limited understanding of their potential for the clinic. This study evaluates the effectiveness in vivo of electrospun chitosan/polylactic acid (Ch/PLA) membranes enriched with silver nanoparticles (AgNPs) for purulent wound treatment. The composite biomaterial integrates chitosan’s biocompatibility and antimicrobial activity with PLA’s structural integrity, while AgNPs enhance antibacterial efficacy against major wound pathogens, including Staphylococcus aureus, Pseudomonas aeruginosa, and Escherichia aureus. A full-thickness purulent wound model was established in a rat model, and the animals were divided into three treatment groups: (i) Ch/PLA, (ii) Ch/PLA-AgNPs, and (iii) PLA-chlorhexidine (control). Wound healing was monitored over 21 days through macroscopic evaluation, histology, immunohistochemistry, and microbiological analysis. The Ch/PLA-AgNPs membranes significantly reduced bacterial colonization within 4–6 days, promoted granulation tissue formation, and accelerated epithelialization compared to the non-modified Ch/PLA scaffold. By day 15, complete wound closure was observed in the Ch/PLA-AgNPs group, comparable to PLA-chlorhexidine-treated wounds. Immunohistochemical analysis revealed a controlled inflammatory response with a balanced macrophage M1/M2 transition, supporting efficient tissue regeneration. Furthermore, systemic toxicity assessments indicated no significant adverse effects on internal organs. These findings demonstrate that electrospun Ch/PLA-AgNPs membranes effectively accelerate purulent wound healing by combining antimicrobial protection with biocompatible tissue support. This innovative approach presents a promising alternative to conventional wound dressings and paves the way for clinical applications in managing infected wounds. Full article
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