Biobased and Biodegradable Polymers for Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 March 2022) | Viewed by 2059

Special Issue Editor


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Guest Editor
Engineering Department, Pontificia Universidad Catolica del Peru—PUCP, Av. Universitaria 1801, Lima 32, Peru
Interests: nanodrugs; drug delivery; natural polymers; oxidoreductase-based enzymatic polymerization; antioxidant polymers; antimicrobial functionalization; medical textiles; polymers for scaffolds and drug delivery applications; pH sensitive polymers for biosensor; wound healing dressing materials; geopolymers for construction

Special Issue Information

Dear Colleagues,

The tremendous economic development is one of the biggest achievements of the 21st centuries. However, humans are also faced with the consequent irrecoverable ecological damage. Plastic pollution is now a global crisis and generates problems at every stage from production to disposal and incineration. Biobased polymers are partially or fully obtained from biomass, or are polymers produced by living organisms. They can be categorized as biodegradable and non-biodegradable polymers. The degradation of polymers generally occurs by biochemical processes like microorganisms-involved degradation, and this is very closely related with environmental issues.

Prof. Dr. Suyeon Kim
Guest Editor

Manuscript Submission Information

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Keywords

  • biodegradable polymers
  • bioplastics
  • biopolymers in medical applications
  • biopolymeric scaffolds
  • sustainability
  • enzymatic degradation
  • byproducts of bioplastics

Published Papers (1 paper)

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Research

19 pages, 4241 KiB  
Article
NIR and Reduction Dual-Sensitive Polymeric Prodrug Nanoparticles for Bioimaging and Combined Chemo-Phototherapy
by Shuying Li, Yanjuan Wu, Xiukun Xue and Siyuan Liu
Polymers 2022, 14(2), 287; https://doi.org/10.3390/polym14020287 - 11 Jan 2022
Cited by 5 | Viewed by 1644
Abstract
The combination of chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT) based on a single nanosystem is highly desirable for cancer treatment. In this study, we developed a versatile Pt(IV) prodrug-based nanodrug, PVPt@Cy NPs, to realize synchronous chemotherapy, PDT and PTT and integrate [...] Read more.
The combination of chemotherapy, photothermal therapy (PTT) and photodynamic therapy (PDT) based on a single nanosystem is highly desirable for cancer treatment. In this study, we developed a versatile Pt(IV) prodrug-based nanodrug, PVPt@Cy NPs, to realize synchronous chemotherapy, PDT and PTT and integrate cancer treatment with bioimaging. To construct PVPt@Cy NPs, the amphiphilic Pt(IV)-based polymeric prodrug PVPt was synthesized by a facile one-pot coupling reaction, and then it was used to encapsulate an optotheranostic agent (HOCyOH, Cy) via hydrophobic interaction-induced self-assembly. These NPs would disaggregate under acidic, reductive conditions and NIR irradiation, which are accompanied by photothermal conversion and reactive oxygen species (ROS) generation. Moreover, the PVPt@Cy NPs exhibited an enhanced in vitro anticancer efficiency with 808-nm light irradiation. Furthermore, the PVPt@Cy NPs showed strong NIR fluorescence and photothermal imaging in H22 tumor-bearing mice, allowing the detection of the tumor site and monitoring of the drug biodistribution. Therefore, PVPt@Cy NPs displayed an enormous potential in combined chemo-phototherapy. Full article
(This article belongs to the Special Issue Biobased and Biodegradable Polymers for Biomedical Applications)
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