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Polymers
Special Issues
Biodegradable Polyesters: Synthesis, Properties, Applications
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Biodegradable Polyesters: Synthesis, Properties, Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biomacromolecules, Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (31 October 2022) | Viewed by 3814

Special Issue Editors

Dr. Anatoly Boyandin

E-Mail Website
Guest Editor
1.Scientific laboratory “Smart Materials and Structures”, Reshetnev Siberian State University of Science and Technology, 660059 Krasnoyarsk, Russia
2. Institute of Biophysics of Siberian Branch of Russian Academy of Sciences (SB RAS), Federal Research Center “Krasnoyarsk Science Center SB RAS”, 660036 Krasnoyarsk, Russia
Interests: polyesters; biodegradable polymers; polymer modification; polymer processing; polymer degradation; composites; slow-release formulations
Dr. Anna Sukhanova

E-Mail Website
Guest Editor
Scientific laboratory “Smart Materials and Structures”, Reshetnev Siberian State University of Science and Technology, 660059 Krasnoyarsk, Russia
Interests: biodegradable polymers; biocompatible polymers; cellular and tissue engineering; composites; polymer degradation; slow-release formulations

Special Issue Information

Dear Colleagues,

Biodegradable polyesters are one of the most important classes of biodegradable polymers, obtained biotechnologically (bacterial PHA), chemically from biotechnologically obtained precursors (e.g., PLA), or purely by chemical synthesis, and can potentially be applied in regenerative medicine (due to the biocompatibility of the main representatives of the group), in manufacturing of packaging materials and other products with a short shelf life, and in the development of controlled delivery systems for medicines and other biologically active agents.

For medical purposes, polymer materials are usually used in the form of scaffolds, films and various hybrid forms, including composites, obtained by various techniques, such as electrospinning, solution casting, molding, etc. The studied polymers and approaches to their processing imply obtaining materials with specified medically important properties.

The use of biodegradable polyesters for the manufacturing of products with a limited shelf life requires maintaining necessary physical and mechanical properties of such products during their use and understanding the timing and mechanisms of their degradation after its completion.

The use of polyester forms (usually granules, micro- or nanoparticles) as carriers for biologically active agents involves the study of the release mechanisms of active components as a result of the diffusion or degradation of the polymer matrix, which depends on the nature of the carrier and environmental conditions.

The main topics of the current Special Issue include:

  • The biological and chemical synthesis of biodegradable polyesters, including copolymers;
  • The physico-chemical modification of polyesters and polymer structures to improve their properties and performance characteristics;
  • Methods of processing polyesters and polyester-based composites into materials and products with specified properties;
  • In vitro, in vivo, and clinical trials of newly designed polymer materials;
  • Patterns of the microbial and non-biological degradation of polyesters;
  • Release patterns of biologically active agents from controlled delivery systems;
  • Topical reviews on the current state and challenges in the field of synthesis, processing, and application of polyesters.

Dr. Anatoly Boyandin
Dr. Anna Sukhanova
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • biodegradable polyesters
  • biomaterials
  • polymer synthesis
  • polymer modification
  • polymer processing
  • composites
  • biomedical materials
  • polymer degradation
  • slow-release systems

Published Papers (2 papers)

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Research

15 pages, 1884 KiB  
Article
Aminolysis of Poly-3-Hydroxybutyrate in N,N-Dimethylformamide and 1,4-Dioxane and Formation of Functionalized Oligomers
by Anatoly Nikolayevich Boyandin, Viktoriya Aleksandrovna Bessonova, Natalya Leonidovna Ertiletskaya, Anna Alekseevna Sukhanova, Taisiya Aleksandrovna Shalygina and Alexander Alexandrovich Kondrasenko
Polymers 2022, 14(24), 5481; https://doi.org/10.3390/polym14245481 - 14 Dec 2022
Cited by 2 | Viewed by 1803
Abstract
The degradation pattern of bacterial poly-3-hydroxybutyrate (PHB) in dimethylformamide (DMF) and dioxane solutions at 100 °C assisted by ethylenediamine, 1,4-diaminobutane and monoaminoethanol was studied. When diamines were introduced into the PHB solution in DMF in the amount of 1 mol of the reagent [...] Read more.
The degradation pattern of bacterial poly-3-hydroxybutyrate (PHB) in dimethylformamide (DMF) and dioxane solutions at 100 °C assisted by ethylenediamine, 1,4-diaminobutane and monoaminoethanol was studied. When diamines were introduced into the PHB solution in DMF in the amount of 1 mol of the reagent to 5 or 10 mol of PHB monomers, a rapid decrease in the molecular weight of the polymer was observed. The initial value of the weight average molecular weight (Mw) 840 kDa had decreased by 20–30 times within the first 10–20 min of the experiment, followed by its gradual decrease to several thousand Da. When a similar molar quantity of aminoethanol was added, the molecular weight decreased slower. PHB had been degrading much slower in the dioxane solution than in DMF. By varying the number of reagents, it was possible to reach stabilization of the Mw at 1000–3000 Da when using diamines and 8000–20,000 Da using aminoethanol. 1H NMR analysis of the oligomers revealed of amino and amido groups forming in their structure. From the opposite end of the polymer chain, residues of 3-hydroxybutyric, crotonic and isocrotonic acids were formed during degradation. Differential scanning calorimetry indicated that after oligomerization there was a decrease in the melting point from 178 °C to 140–170 °C depending on the decrease in the molecular weight. The method proposed can be used for obtaining aminated PHB oligomers. Full article
(This article belongs to the Special Issue Biodegradable Polyesters: Synthesis, Properties, Applications)
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15 pages, 3059 KiB  
Article
The Effect of Solvent Hydrophilicity on the Enzymatic Ring-Opening Polymerization of L-Lactide by Candida rugosa Lipase
by Catia Angli Curie, Muhammad Arif Darmawan, Dianursanti Dianursanti, Wiratni Budhijanto and Misri Gozan
Polymers 2022, 14(18), 3856; https://doi.org/10.3390/polym14183856 - 15 Sep 2022
Cited by 3 | Viewed by 1730
Abstract
Contradictions have been reported on the effect of organic solvents, especially toluene, on enzymatic ring-opening polymerization (eROP) of L-lactide. Studies have shown that log P, a common measure of hydrophilicity, affects enzyme activity. This study examines the effect of solvents with various log [...] Read more.
Contradictions have been reported on the effect of organic solvents, especially toluene, on enzymatic ring-opening polymerization (eROP) of L-lactide. Studies have shown that log P, a common measure of hydrophilicity, affects enzyme activity. This study examines the effect of solvents with various log P values on the eROP of L-lactide, performed using Candida rugosa lipase (CRL). N,N-dimethylacetamide (DMA), 1,2-dimethoxybenzene, 1,4-dimethoxybenzene, diphenyl ether, and dodecane were used as the organic solvents. The eROP in ionic liquid 1-butyl-3-methylimidazolium hexafluorophosphate ([BMIM][PF6]) was also conducted to compare its performance with the organic solvents. The results show that [BMIM][PF6]-mediated eROP gave better conversion and molecular weight than the organic solvent-mediated eROP. In this study, the effects of solvents hydrophilicity are discussed, including the possibility of hexafluorophosphate ion ([PF6]−) hydrolysis to occur. Full article
(This article belongs to the Special Issue Biodegradable Polyesters: Synthesis, Properties, Applications)
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