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21 pages, 3139 KiB

Open AccessArticle

Poly(vinyl alcohol)-tannic Acid Cryogel Matrix as Antioxidant and Antibacterial Material

by Betul Ari, Mehtap Sahiner, Sahin Demirci and Nurettin Sahiner

Polymers 2022, 14(1), 70; https://doi.org/10.3390/polym14010070 - 25 Dec 2021

Cited by 18 | Viewed by 4037

Abstract

The biocompatible, viscoelastic properties of poly(vinyl alcohol) (PVA) in combination with the antimicrobial and antioxidant natural polyphenolic, tannic acid (TA), and the natural flavonoid and antioxidant curcumin (Cur), were used in the preparation of PVA:TA and PVA:TA:Cur cryogel composites using cryotropic gelation to [...] Read more.

The biocompatible, viscoelastic properties of poly(vinyl alcohol) (PVA) in combination with the antimicrobial and antioxidant natural polyphenolic, tannic acid (TA), and the natural flavonoid and antioxidant curcumin (Cur), were used in the preparation of PVA:TA and PVA:TA:Cur cryogel composites using cryotropic gelation to combine the individually beneficial properties. The effect of TA content on the antioxidant and antimicrobial activities of PVA:TA cryogel composites and the antioxidant activities of PVA:TA:Cur cryogel composites was determined using Trolox equivalent antioxidant capacity (TEAC) and total phenol content (TPC) assays, and were compared. The PVA:TA:Cur cryogel composite showed the highest antioxidant activity, with a TEAC value of 2.10 ± 0.24 and a TPC value of 293 ± 12.00. The antibacterial capacity of the PVA:TA and PVA:TA:Cur 1:1:0.1 cryogel composites was examined against two different species of bacteria, E. coli and S. aureus. It was found that the minimum inhibition concentration (MIC) value of the PVA:TA:Cur 1:1:0.1 cryogel composites varied between 5 and 10 mg/mL based on the type of microorganism, and the minimum bactericidal concentration (MBC) value was 20 mg/mL irrespective of the type of microorganism. Furthermore, the hemocompatibility of the PVA:TA cryogel composites was evaluated by examining their hemolytic and coagulation behaviors. PVA:TA 1:1 cryogels with a value of 95.7% revealed the highest blood clotting index value amongst all of the synthesized cryogels, signifying the potential for blood contacting applications. The release of TA and Cur from the cryogel composites was quantified at different pH conditions, i.e., 1.0, 7.4, and 9.0, and additionally in ethanol (EtOH) and an ethanol–water (EtOH:Wat) mixture. The solution released from the PVA:TA cryogels in PBS was tested for inhibition capability against α-glucosidase (E.C. 3.2.1.20). Concentration-dependent enzyme inhibition was observed, and 70 µL of 83 µg/mL PVA:TA (1:1) cryogel in PBS inhibited α-glucosidase enzyme solution of 0.03 unit/mL in 70 µL by 81.75 ± 0.96%. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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17 pages, 4410 KiB

Open AccessArticle

Rapid Functionalization of Polytetrafluorethylene (PTFE) Surfaces with Nitrogen Functional Groups

by Alenka Vesel, Rok Zaplotnik, Gregor Primc, Miran Mozetič, Tadeja Katan, Rupert Kargl, Tamilselvan Mohan and Karin Stana Kleinschek

Polymers 2021, 13(24), 4301; https://doi.org/10.3390/polym13244301 - 9 Dec 2021

Cited by 4 | Viewed by 3722

Abstract

The biocompatibility of body implants made from polytetrafluoroethylene (PTFE) is inadequate; therefore, the surface should be grafted with biocompatible molecules. Because PTFE is an inert polymer, the adhesion of the biocompatible film may not be appropriate. Therefore, the PFTE surface should be modified [...] Read more.

The biocompatibility of body implants made from polytetrafluoroethylene (PTFE) is inadequate; therefore, the surface should be grafted with biocompatible molecules. Because PTFE is an inert polymer, the adhesion of the biocompatible film may not be appropriate. Therefore, the PFTE surface should be modified to enable better adhesion, preferably by functionalization with amino groups. A two-step process for functionalization of PTFE surface is described. The first step employs inductively coupled hydrogen plasma in the H-mode and the second ammonia plasma. The evolution of functional groups upon treatment with ammonia plasma in different modes is presented. The surface is saturated with nitrogen groups within a second if ammonia plasma is sustained in the H-mode at the pressure of 35 Pa and forward power of 200 W. The nitrogen-rich surface film persists for several seconds, while prolonged treatment causes etching. The etching is suppressed but not eliminated using pulsed ammonia plasma at 35 Pa and 200 W. Ammonia plasma in the E-mode at the same pressure, but forward power of 25 W, causes more gradual functionalization and etching was not observed even at prolonged treatments up to 100 s. Detailed investigation of the XPS spectra enabled revealing the surface kinetics for all three cases. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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15 pages, 3759 KiB

Open AccessArticle

Isolation of Microbulbifer sp. SOL66 with High Polyhydroxyalkanoate-Degrading Activity from the Marine Environment

by Sol Lee Park, Jang Yeon Cho, Su Hyun Kim, Shashi Kant Bhatia, Ranjit Gurav, See-Hyoung Park, Kyungmoon Park and Yung-Hun Yang

Polymers 2021, 13(23), 4257; https://doi.org/10.3390/polym13234257 - 4 Dec 2021

Cited by 21 | Viewed by 2725

Abstract

Having the advantage of eco-friendly decomposition, bioplastics could be used to replace petroleum-based plastics. In particular, poly(3-hydroxybutyrate) (PHB) is one of the most commercialized bioplastics, however, necessitating the introduction of PHB-degrading bacteria for its effective disposal. In this study, Microbulbifer sp. SOL66 (94.18% [...] Read more.

Having the advantage of eco-friendly decomposition, bioplastics could be used to replace petroleum-based plastics. In particular, poly(3-hydroxybutyrate) (PHB) is one of the most commercialized bioplastics, however, necessitating the introduction of PHB-degrading bacteria for its effective disposal. In this study, Microbulbifer sp. SOL66 (94.18% 16S rRNA with similarity to Microbulbifer hydrolyticus) demonstrated the highest degradation activity among five newly screened Microbulbifer genus strains. Microbulbifer sp. SOL66 showed a rapid degradation yield, reaching 98% in 4 days, as monitored by laboratory scale, gas chromatography-mass spectrometry, scanning electron microscopy, gel permeation chromatography, and Fourier transform infrared spectroscopy. The PHB film was completely degraded within 7 days at 37 °C in the presence of 3% NaCl. When 1% xylose and 0.4% ammonium sulfate were added, the degradation activity increased by 17% and 24%, respectively. In addition, this strain showed biodegradability on pellets of poly(3-hydroxybutyrate-co-4-hydroxybutyrate), as confirmed by weight loss and physical property changes. We confirmed that Microbulbifer sp. SOL66 has a great ability to degrade PHB, and has rarely been reported to date. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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14 pages, 6608 KiB

Open AccessArticle

Tubular Electrospun Vancomycin-Loaded Vascular Grafts: Formulation Study and Physicochemical Characterization

by Rossella Dorati, Enrica Chiesa, Mariella Rosalia, Silvia Pisani, Ida Genta, Giovanna Bruni, Tiziana Modena and Bice Conti

Polymers 2021, 13(13), 2073; https://doi.org/10.3390/polym13132073 - 24 Jun 2021

Cited by 12 | Viewed by 2491

Abstract

This work aimed at formulating tubular grafts electrospun with a size < 6 mm and incorporating vancomycin as an antimicrobial agent. Compared to other papers, the present study succeeded in using medical healthcare-grade polymers and solvents permitted by ICH Topic Q3C (R4). Vancomycin [...] Read more.

This work aimed at formulating tubular grafts electrospun with a size < 6 mm and incorporating vancomycin as an antimicrobial agent. Compared to other papers, the present study succeeded in using medical healthcare-grade polymers and solvents permitted by ICH Topic Q3C (R4). Vancomycin (VMC) was incorporated into polyester synthetic polymers (poly-L-lactide-co-poly-ε-caprolactone and poly lactide-co-glycolide) using permitted solvents; moreover, a surfactant was added to the formulation in order to avoid the precipitation of VMC on fiber surface. A preliminary preformulation study was carried out to evaluate solubility of VMC in different aqueous and organic solvents and its stability. To reduce size of fibers and their orientation, we studied a solvent system based on methylene chloride and acetone (DCM/acetone), at different ratios (80:20, 70:30, and 60:40). Considering conductivity of solutions and their spinnability, solvent system at a 80:20 ratio was selected for the study. SEM images demonstrated that size of fibers, their distribution, and their orientation were affected by the incorporation of VMC and surfactant into polymer solution. Surfactant allowed for the reduction of precipitates of VMC on fiber surface, which are responsible of the high burst release in the first six hours; the release was mainly dependent on graft structure porosity, number of pores, and graft absorbent capability. A controlled release of VMC was achieved, covering a period from 96 to 168 h as a function of composition and structure; the concentration of VMC was significantly beyond VMC minimum inhibitory concentration (MIC, 2 ug/mL). These results indicated that the VMC tubular electrospun grafts not only controlled the local release of VMC, but also avoided onset of antibiotic resistance. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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18 pages, 3772 KiB

Open AccessArticle

Progress of Disintegration of Polylactide (PLA)/Poly(Butylene Succinate) (PBS) Blends Containing Talc and Chalk Inorganic Fillers under Industrial Composting Conditions

by Sengül Tolga, Stephan Kabasci and Mona Duhme

Polymers 2021, 13(1), 10; https://doi.org/10.3390/polym13010010 - 22 Dec 2020

Cited by 22 | Viewed by 4173

Abstract

Biodegradable plastics are experiencing increasing demand, in particular because of said property. This also applies to the two biopolyesters poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) covered in this study. Both are proven to be biodegradable under industrial composting conditions. This study presents [...] Read more.

Biodegradable plastics are experiencing increasing demand, in particular because of said property. This also applies to the two biopolyesters poly(lactic acid) (PLA) and poly(butylene succinate) (PBS) covered in this study. Both are proven to be biodegradable under industrial composting conditions. This study presents the influence of mineral fillers on the disintegration process of PLA/PBS blend systems under such conditions. Chalk and talc were used as fillers in PLA/PBS (7:3) blend systems. In addition, unfilled PLA/PBS (7:3/3:7) blend systems were considered. Microscopic images, differential scanning calorimetry and tensile test measurements were used in addition to measuring mass loss of the specimen to characterize the progress of disintegration. The mineral fillers used influence the disintegration behavior of PLA/PBS blends under industrial composting conditions. In general, talc leads to lower and chalk to higher disintegration rates. This effect is in line with the measured decrease in mechanical properties and melting enthalpies. The degrees of disintegration almost linearly correlate with specimen thickness, while different surface textures showed no clear effects. Thus, we conclude that disintegration in a PLA/PBS system proceeds as a bulk erosion process. Using fillers to control the degradation process is generally regarded as possible. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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12 pages, 991 KiB

Open AccessArticle

Biodeterioration of Untreated Polypropylene Microplastic Particles by Antarctic Bacteria

by Syahir Habib, Anastasia Iruthayam, Mohd Yunus Abd Shukor, Siti Aisyah Alias, Jerzy Smykla and Nur Adeela Yasid

Polymers 2020, 12(11), 2616; https://doi.org/10.3390/polym12112616 - 6 Nov 2020

Cited by 87 | Viewed by 7389

Abstract

Microplastic pollution is globally recognised as a serious environmental threat due to its ubiquitous presence related primarily to improper dumping of plastic wastes. While most studies have focused on microplastic contamination in the marine ecosystem, microplastic pollution in the soil environment is generally [...] Read more.

Microplastic pollution is globally recognised as a serious environmental threat due to its ubiquitous presence related primarily to improper dumping of plastic wastes. While most studies have focused on microplastic contamination in the marine ecosystem, microplastic pollution in the soil environment is generally little understood and often overlooked. The presence of microplastics affects the soil ecosystem by disrupting the soil fertility and quality, degrading the food web, and subsequently influencing both food security and human health. This study evaluates the growth and biodegradation potential of the Antarctic soil bacteria Pseudomonas sp. ADL15 and Rhodococcus sp. ADL36 on the polypropylene (PP) microplastics in Bushnell Haas (BH) medium for 40 days. The degradation was monitored based on the weight loss of PP microplastics, removal rate constant per day (K), and their half-life. The validity of the PP microplastics’ biodegradation was assessed through structural changes via Fourier transform infrared spectroscopy analyses. The weight loss percentage of the PP microplastics by ADL15 and ADL36 after 40 days was 17.3% and 7.3%, respectively. The optimal growth in the BH media infused with PP microplastics was on the 40th and 30th day for ADL15 and ADL36, respectively. The infrared spectroscopic analysis revealed significant changes in the PP microplastics’ functional groups following the incubation with Antarctic strains. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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16 pages, 6319 KiB

Open AccessArticle

Shape Memory Polymer Foams Synthesized Using Glycerol and Hexanetriol for Enhanced Degradation Resistance

by Sayyeda Marziya Hasan, Grace K. Fletcher, Mary Beth Browning Monroe, Mark A. Wierzbicki, Landon D. Nash and Duncan J. Maitland

Polymers 2020, 12(10), 2290; https://doi.org/10.3390/polym12102290 - 6 Oct 2020

Cited by 11 | Viewed by 3337

Abstract

Shape memory polymer foams have been used in a wide range of medical applications, including, but not limited to, vessel occlusion and aneurysm treatment. This unique polymer system has been proven to shape-fill a void, which makes it useful for occlusion applications. While [...] Read more.

Shape memory polymer foams have been used in a wide range of medical applications, including, but not limited to, vessel occlusion and aneurysm treatment. This unique polymer system has been proven to shape-fill a void, which makes it useful for occlusion applications. While the shape memory polymer foam has superior performance and healing outcomes compared to its leading competitors, some device applications may benefit from longer material degradation times, or degradation-resistant formulations with increased fibrous encapsulation. In this study, biostable shape memory polymer foams were synthesized, and their physical and chemical properties were characterized as an initial evaluation of feasibility for vascular occlusion applications. After characterizing their shape memory behavior in an aqueous environment, degradation of this polymer system was studied in vitro using accelerated oxidative and hydrolytic solutions. Results indicated that the foams did not lose mass under oxidative or hydrolytic conditions, and they maintained high shape recovery in aqueous in vitro models. These degradation-resistant systems have potential for use in vascular occlusion and other wound healing applications that benefit from permanent, space-filling shape memory behavior. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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Review

Jump to: Research

21 pages, 795 KiB

Open AccessReview

In Vitro Evaluation of Biomaterials for Vocal Fold Injection: A Systematic Review

by Ng Wan-Chiew, Marina Mat Baki, Mh Busra Fauzi, Yogeswaran Lokanathan and Mawaddah Azman

Polymers 2021, 13(16), 2619; https://doi.org/10.3390/polym13162619 - 6 Aug 2021

Cited by 5 | Viewed by 2541

Abstract

Vocal fold injection is a preferred treatment in glottic insufficiency because it is relatively quick and cost-saving. However, researchers have yet to discover the ideal biomaterial with properties suitable for human vocal fold application. The current systematic review employing PRISMA guidelines summarizes and [...] Read more.

Vocal fold injection is a preferred treatment in glottic insufficiency because it is relatively quick and cost-saving. However, researchers have yet to discover the ideal biomaterial with properties suitable for human vocal fold application. The current systematic review employing PRISMA guidelines summarizes and discusses the available evidence related to outcome measures used to characterize novel biomaterials in the development phase. The literature search of related articles published within January 2010 to March 2021 was conducted using Scopus, Web of Science (WoS), Google Scholar and PubMed databases. The search identified 6240 potentially relevant records, which were screened and appraised to include 15 relevant articles based on the inclusion and exclusion criteria. The current study highlights that the characterization methods were inconsistent throughout the different studies. While rheologic outcome measures (viscosity, elasticity and shear) were most widely utilized, there appear to be no target or reference values. Outcome measures such as cellular response and biodegradation should be prioritized as they could mitigate the clinical drawbacks of currently available biomaterials. The review suggests future studies to prioritize characterization of the viscoelasticity (to improve voice outcomes), inflammatory response (to reduce side effects) and biodegradation (to improve longevity) profiles of newly developed biomaterials. Full article

(This article belongs to the Special Issue Degradation and Biological Application of Polymers)

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