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Bioactive Supramolecular Assemblies

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Biobased and Biodegradable Polymers".

Deadline for manuscript submissions: closed (15 January 2022) | Viewed by 5658

Special Issue Editors


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Guest Editor
Biocolloids Laboratory, Department of Biochemistry, Institute of Chemistry, São Paulo State University, São Paulo, SP, Brazil
Interests: bioactive supramolecular assemblies; drug and vaccine delivery; antimicrobial biomimetics; cationic antimicrobial polymers; novel formulations for vaccines design; hybrid assemblies of polymers with cationic lipids, surfactants and nanoparticles; biocompatible polymers and their assemblies; nanostructured coatings; nanoparticles; lipid polymer assemblies; biomimetic lipid-polymer particles; synthesis and characterization of biocompatible nanoparticles; antimicrobial activity of cationic lipids, surfactants and their assemblies with polymers; polymers and their assemblies for drug and vaccine delivery applications; biomimetic nanotechnology; cationic nanostructures for vaccine design

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Guest Editor
Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, 09606-070 SP, Brazil
Interests: polymers; tissue engineering; in vitro assays; in vivo assays

Special Issue Information

Dear Colleagues,

In recent years, polymers have enabled the development of novel and hybrid supramolecular assemblies. Some of their important applications in biomedical research include vaccine design, optimization of antimicrobial action against resistant microbes, and the protection of active principles against biodegradation. Polymeric-based constructions often rely on non-covalent, multipoint intermolecular interactions between polymers and a variety of biomolecules, surfactants, antigens, drugs, antibiotics, and so forth.

Immunoadjuvants and antimicrobial assemblies are some examples of effective bioactive devices, whose assemblies can be shaped as liposomes, nanoparticles, disks, coatings, hydrogels, multifunctional and layered nanostructures, just to mention a few. Moreover, bioactive novel assemblies must also exhibit another equally important property: negligible in vivo and in vitro toxicity.

The interdisciplinary character of this research area requires contributions from physical and organic chemists, pharmacists, biologists, immunologists, microbiologists, engineers, and medical doctors. Thus, this ambitious Special Issue will combine different fields of knowledge to paint a cohesive picture of the multiple roles of polymers in a variety of biotechnological, biomedical, and pharmaceutical applications. Innovative approaches and broad and comprehensive reviews are especially welcome.

Prof. Dr. Ana Maria Carmona-Ribeiro
Prof. Dr. Arnaldo Rodrigues Santos Júnior
Guest Editors

Manuscript Submission Information

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Keywords

  • Polyacrylates
  • Biocompatible polymers
  • Biodegradable polymers
  • Lipids and surfactants
  • Hybrid lipid polymer assemblies
  • Cationic antimicrobial polymers
  • Polymers and their assemblies in drug and vaccine delivery
  • Antigen presentation by bioactive assemblies
  • Toxicity of bioactive polymers and their assemblies

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Published Papers (2 papers)

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Research

14 pages, 2712 KiB  
Article
Effect of Chitosan on the Activity of Water-Soluble and Hydrophobic Porphyrin Photosensitizers Solubilized by Amphiphilic Polymers
by Valeriya V. Kardumyan, Nadejda A. Aksenova, Victoria A. Timofeeva, Alexey V. Krivandin, Olga V. Shatalova, Alexander S. Dubovik, Irina G. Plashchina, Peter S. Timashev and Anna B. Solovieva
Polymers 2021, 13(7), 1007; https://doi.org/10.3390/polym13071007 - 25 Mar 2021
Cited by 9 | Viewed by 2509
Abstract
In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan [...] Read more.
In this work, we studied the photocatalytic activity of photosensitizers (PSs) of various natures solubilized with polyvinylpyrrolidone (PVP) and ternary block copolymer ethylene and propylene oxide Pluronic F127 (F127) in a model reaction of tryptophan photo-oxidation in water in the presence of chitosan (CT). Water-soluble compounds (dimegin and trisodium salt of chlorin e6 (Ce6)) and hydrophobic porphyrins (tetraphenylporphyrin (TPP) and its fluorine derivative (TPPF20)) were used as PSs. It was shown that the use of chitosan (Mw ~100 kDa) makes it possible to obtain a system whose activity is comparable to that of the photosensitizer-amphiphilic polymer systems. Thus, the previously observed drop in the photosensitizing activity of PS in the presence of a polysaccharide and amphiphilic polymers (AP) was absent in this case. At the same time, chitosan had practically no inhibitory effect on hydrophobic porphyrins solubilized by Pluronic F127. Full article
(This article belongs to the Special Issue Bioactive Supramolecular Assemblies)
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17 pages, 3663 KiB  
Article
Biocompatible Lipid Polymer Cationic Nanoparticles for Antigen Presentation
by Yunys Pérez-Betancourt, Bianca de Carvalho Lins Fernandes Távora, Eliana L. Faquim-Mauro and Ana Maria Carmona-Ribeiro
Polymers 2021, 13(2), 185; https://doi.org/10.3390/polym13020185 - 7 Jan 2021
Cited by 9 | Viewed by 2705
Abstract
Biocompatible lipid polymer nanoparticles (NPs) previously used as antimicrobial agents are explored here as immuno-adjuvants. Poly (methyl methacrylate) (PMMA)/dioctadecyldimethylammonium bromide (DODAB)/poly (diallyldimethylammonium chloride) (PDDA) nanoparticles (NPs) were prepared by emulsion polymerization of methyl methacrylate (MMA) in the presence of DODAB and PDDA, with [...] Read more.
Biocompatible lipid polymer nanoparticles (NPs) previously used as antimicrobial agents are explored here as immuno-adjuvants. Poly (methyl methacrylate) (PMMA)/dioctadecyldimethylammonium bromide (DODAB)/poly (diallyldimethylammonium chloride) (PDDA) nanoparticles (NPs) were prepared by emulsion polymerization of methyl methacrylate (MMA) in the presence of DODAB and PDDA, with azobisisobutyronitrile (AIBN) as the initiator. NPs characterization after dialysis by dynamic light-scattering yielded 225 ± 2 nm hydrodynamic diameter (Dz), 73 ± 1 mV zeta-potential (ζ), and 0.10 ± 0.01 polydispersity (P). Ovalbumin (OVA) adsorption reduced ζ to 45 ± 2 mV. Balb/c mice immunized with NPs/OVA produced enhanced OVA-specific IgG1 and IgG2a, exhibited moderate delayed type hypersensitivity reaction, and enhanced cytokines production (IL-4, IL-10, IL-2, IFN-γ) by cultured spleen cells. There was no cytotoxicity against cultured macrophages and fibroblasts. Advantages of the PMMA/DODAB/PDDA NPs were high biocompatibility, zeta-potential, colloidal stability, and antigen adsorption. Both humoral and cellular antigen-specific immune responses were obtained. Full article
(This article belongs to the Special Issue Bioactive Supramolecular Assemblies)
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