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Processes
Special Issues
Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds
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Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Separation Processes".

Deadline for manuscript submissions: 15 April 2025 | Viewed by 3578

Special Issue Editors

Prof. Dr. Juan Antonio Nieto

E-Mail Website
Guest Editor
Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Science, Universidad Internacional de Valencia (VIU), E46002 Valencia, Spain
Interests: extraction; bioactivity; bioavailability; microbiota
Prof. Mariana Silva López

E-Mail Website
Guest Editor
Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Science, Universidad Internacional de Valencia (VIU), E46002 Valencia, Spain
Interests: extraction; bioactivity; analytical techniques
Prof. Teodoro Suárez Diéguez

E-Mail Website
Guest Editor
Área Académica de Nutrición, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto E42000, Hidalgo, Mexico
Interests: extraction; bioactivity; atarch

Special Issue Information

Dear Colleagues,

Given the growing importance of ensuring more sustainable industrial processes and, at the same time, the need to find solutions to reduce the incidence and impact of chronic pathologies such as metabolic syndrome, extracting and obtaining bioactive compounds from natural products has become a priority for pharmacy, biomedicine, and food technology and engineering. Recovering bioactive compounds from industrial by‑products and wastes to develop more sustainable producing systems is attracting interest throughout the scientific community. Some of the hallmarks of process integration and intensification for bioactive compounds recovery include a holistic perspective on the design and enhancement of the extraction procedures to allow for more efficient extractions, as well as the creation of purification procedures that allow enhanced bioactive natural products.

This Special Issue on “Sustainable techniques for extraction and isolation of natural bioactive compounds” seeks high-quality works focusing on recent advances in the development and application of extraction and purification process for bioactive compound recovery and extraction from natural sources or industrial by‑products and wastes. Topics include, but are not limited to, methods and/or applications in the following areas:

  • Conventional extraction techniques applied to recover bioactive compounds from industrial by‑products or wastes;
  • Advanced extraction techniques applied to recover bioactive compounds from industrial by‑products or wastes, such as PLE, UAE, or SFC;
  • Innovative extraction techniques applied to recover bioactive compounds from industrial by products or wastes, such as extraction assisted by enzymes, pulsed electric fields (PEFs), etc.;
  • Optimization of extraction procedures through experimental design;
  • Purification procedures to obtain purer extracts or bioactive compounds;
  • Purification procedures to obtain more efficient bioactive extracts.

Prof. Dr. Juan Antonio Nieto
Prof. Mariana Silva López
Prof. Teodoro Suárez Diéguez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products
  • purification
  • pressurized liquid extraction
  • supercritical fluid extractions
  • ultrasound-assisted extraction
  • advanced extraction
  • solid–liquid extraction
  • sistainable extraction
  • eutectic solvents

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Published Papers (4 papers)

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Research

20 pages, 2049 KiB  
Article
Biovalorization of Aquaculture Biofloc Waste Through Polyphenol Extraction by Alkaline Hydrolysis and Green Nanoparticle Synthesis Optimization
by Robson M. M. Gomes, Juan R. B. Ramírez, Alan C. S. Araujo, Andressa C. Pereira, Cynthia M. O. Couto, Corina Rojas, Luiz A. Pinto, Tito Junior, Daniela F. Ramos and José M. Monserrat
Processes 2025, 13(1), 29; https://doi.org/10.3390/pr13010029 - 26 Dec 2024
Viewed by 414
Abstract
The present research aims to valorize biofloc waste by extracting polyphenols via alkaline hydrolysis, utilizing them as reducing and stabilizing agents in the optimization of green synthesis of silver nanoparticles (BIOAgNPs). For the alkaline extractions, potassium hydroxide (KOH) concentrations of 0 to 4 [...] Read more.
The present research aims to valorize biofloc waste by extracting polyphenols via alkaline hydrolysis, utilizing them as reducing and stabilizing agents in the optimization of green synthesis of silver nanoparticles (BIOAgNPs). For the alkaline extractions, potassium hydroxide (KOH) concentrations of 0 to 4 M were used in combination with ultrasound. Total polyphenol content and antioxidant activity were evaluated. BIOAgNPs synthesis was optimized using the response surface methodology and central composite design. The parameters time, temperature, AgNO3 concentration, and the percentage of the biofloc extract (2 M KOH), with measurements taken for the area under the curve (AUC) (400–500 nm) and the mean hydrodynamic diameter (DLS), were evaluated. Antibacterial activity was determined for Gram-negative and Gram-positive bacteria. Higher polyphenol content and antioxidant activity were observed using 2 M KOH. The optimized model for DLS and the AUC was obtained in 4 h, at 40 °C, using 2.4 mM AgNO3 and obtaining 2.5% of extract. Optimized BIOAgNPs had a diameter of 22.4 nm, hydrodynamic diameter of 106.5 nm, zeta potential of −28 mV, and polydispersity index of 0.26. BIOAgNPs demonstrated bactericidal activities. This study enhanced the valorization of aquaculture residues through improved polyphenol extraction techniques and developed an effective methodology for synthesizing silver nanoparticles with antimicrobial activity. Full article
(This article belongs to the Special Issue Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds)
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20 pages, 2372 KiB  
Article
Comprehensive Study of Sustainable Pressurized Liquid Extractions to Obtain Bioavailable Antioxidant Phenolic Compounds from Grape Seed By-Products
by Juan Antonio Nieto, Susana Santoyo, Marta de Sá, Sun Baoshan, Guillermo Reglero and Laura Jaime
Processes 2024, 12(11), 2308; https://doi.org/10.3390/pr12112308 - 22 Oct 2024
Viewed by 842
Abstract
Few investigations have been conducted to evaluate pressurized liquid extraction (PLE) technology as a sustainable method for the recovery of phenolic compounds of grape seed by-products. In this study, PLE combined with an experimental design was evaluated for optimizing the sustainable extraction of [...] Read more.
Few investigations have been conducted to evaluate pressurized liquid extraction (PLE) technology as a sustainable method for the recovery of phenolic compounds of grape seed by-products. In this study, PLE combined with an experimental design was evaluated for optimizing the sustainable extraction of phenolic compounds from grape seed by-products. The solvent ethanol content (X1, 0–100%), temperature (X2, 20–100 °C) and time (X3, 1–11 min) were studied as independent experimental factors. Yield, TPC, antioxidant activity and phenolic composition were analyzed as optimized dependent variables. Two optimal extraction conditions at different temperatures (20 °C and 100 °C) were found, but thermal degradations at 100 °C allowed for selecting the optimal condition as 75% ethanol, 11 min and 20 °C. The optimal extracts showed high phenolic content (TPC = 350.80 ± 3.97 mg GAE/g extract) and antioxidant activity (ABTS, 9.31 ± 0.33 mmol Trolox/g extract), mainly composed of polymeric and mono-oligomeric flavan-3-ols. The digestion process reduced the TPC and antioxidant activity due to the low bioaccessibility of the flavan-3-ols, mainly as catechin, epicatechin and polymeric proanthocyanidin losses during the digestion process. However, increases in the antioxidant activity of the basolateral side (DDPH, 0.061 ± 0.000 mmol Trolox/g extract) were determined after in vitro transepithelial transport, which is a consequence of bioavailable catechin and epicatechin and reduced amounts of dimer B2, dimer B1, epicatechin gallate and gallic acid. Consequently, PLE combined with hydroalcoholic solvents at a low temperature resulted in a valuable methodology to obtain sustainable extracts from grape seed by-products (contributing to the circular economy), containing bioavailable phenolic compounds, which are able to increase the antioxidant status. Full article
(This article belongs to the Special Issue Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds)
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18 pages, 5183 KiB  
Article
Enhanced Extraction of Tanshinones from Salvia miltiorrhiza Using Natural-Surfactant-Based Cloud Point Extraction
by Yerim Shin, Byeongryeol Ryu, Minji Kang, Minjun Kim and Jungdae Lim
Processes 2024, 12(10), 2227; https://doi.org/10.3390/pr12102227 - 12 Oct 2024
Viewed by 846
Abstract
Salvia miltiorrhiza (SM) contains the tanshinones, a compound with various pharmacological effects, and has been extensively studied as a pharmaceutical material. However, conventional methods for extracting tanshinones face challenges such as environmental hazards and high cost. In this study, we aimed to effectively [...] Read more.
Salvia miltiorrhiza (SM) contains the tanshinones, a compound with various pharmacological effects, and has been extensively studied as a pharmaceutical material. However, conventional methods for extracting tanshinones face challenges such as environmental hazards and high cost. In this study, we aimed to effectively extract tanshinones from SM using cloud point extraction (CPE) with lecithin, a natural surfactant. By optimizing various extraction conditions including the solid-to-liquid ratio, lecithin concentration, NaCl concentration, pH, and equilibrium temperature, the optimal extraction efficiency was achieved using 20 mL of solvent per 1 g of sample, 3% lecithin (w/v), 2% NaCl (w/v), pH 6, and room temperature (25 ± 2 °C). The CPE method, which minimizes the use of organic solvent and is eco-friendly, demonstrated improvements in extraction efficiency, with a 4.55% increase for dihydrotanshinone I, 8.32% for cryptotanshinone, 15.77% for tanshinone I, and 6.81% for tanshinone IIA compared to the conventional water extraction method. These results suggest that CPE is a promising, environmentally friendly, and efficient approach for extracting hydrophobic components from pharmacologically active materials such as SM, with potential applications across various fields of natural product extraction. Full article
(This article belongs to the Special Issue Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds)
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11 pages, 1447 KiB  
Article
Assessment of Yield, Flavonoid and Phytosterol Contents, and Fatty Acid Composition of Baru Almond Oil (Dipteryx alata Vogel) by Supercritical CO2 Extraction
by Ana Carolina Ferreira, Guilherme Lopes, Antonio Carlos Filho, Najla Postaue, Celso Belisário, Leonardo Lataro Paim, Lúcio Cardozo-Filho, Camila da Silva, Leandro Ferreira-Pinto and Rogério Favareto
Processes 2024, 12(8), 1729; https://doi.org/10.3390/pr12081729 - 16 Aug 2024
Viewed by 894
Abstract
The objective of this study was to investigate the influence of temperature and pressure on the extraction of Baru almond oil using pressurized CO2. From the obtained data, it was found that variations in pressure and temperature influenced the oil yield [...] Read more.
The objective of this study was to investigate the influence of temperature and pressure on the extraction of Baru almond oil using pressurized CO2. From the obtained data, it was found that variations in pressure and temperature influenced the oil yield and total amount of phytosterols. The maximum yield of Baru oil achieved was approximately 30%, obtained at a pressure of 28 MPa and 60 °C. The phytosterols identified were campesterol, stigmasterol, and β-sitosterol, with a maximum content of 169.5 ± 4.2 mg/100 g of oil obtained at 20 MPa and 60 °C. Among these, β-sitosterol was the most abundant, accounting for 60% of the total phytosterol content under all the experimental conditions. The flavonoid content in the extracts was also quantified, with the total flavonoid levels ranging between 255 and 275 mg/100 g of oil depending on the experimental conditions. The fatty acid profile of the extracted oil predominantly consisted of oleic (51%) and linoleic (28%) acids. Full article
(This article belongs to the Special Issue Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds)
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