Sustainable Techniques for Extraction and Isolation of Natural Bioactive Compounds

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Separation Processes".

Deadline for manuscript submissions: 15 November 2024 | Viewed by 1506

Special Issue Editors


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Guest Editor
Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Science, Universidad Internacional de Valencia (VIU), E46002 Valencia, Spain
Interests: extraction; bioactivity; bioavailability; microbiota

E-Mail Website
Guest Editor
Bioactivity and Nutritional Immunology Group (BIOINUT), Faculty of Health Science, Universidad Internacional de Valencia (VIU), E46002 Valencia, Spain
Interests: extraction; bioactivity; analytical techniques

E-Mail Website
Guest Editor
Área Académica de Nutrición, Instituto de Ciencias de la Salud, Universidad Autónoma del Estado de Hidalgo, Pachuca de Soto E42000, Hidalgo, Mexico
Interests: extraction; bioactivity; atarch

Special Issue Information

Dear Colleagues,

Given the growing importance of ensuring more sustainable industrial processes and, at the same time, the need to find solutions to reduce the incidence and impact of chronic pathologies such as metabolic syndrome, extracting and obtaining bioactive compounds from natural products has become a priority for pharmacy, biomedicine, and food technology and engineering. Recovering bioactive compounds from industrial by‑products and wastes to develop more sustainable producing systems is attracting interest throughout the scientific community. Some of the hallmarks of process integration and intensification for bioactive compounds recovery include a holistic perspective on the design and enhancement of the extraction procedures to allow for more efficient extractions, as well as the creation of purification procedures that allow enhanced bioactive natural products.

This Special Issue on “Sustainable techniques for extraction and isolation of natural bioactive compounds” seeks high-quality works focusing on recent advances in the development and application of extraction and purification process for bioactive compound recovery and extraction from natural sources or industrial by‑products and wastes. Topics include, but are not limited to, methods and/or applications in the following areas:

  • Conventional extraction techniques applied to recover bioactive compounds from industrial by‑products or wastes;
  • Advanced extraction techniques applied to recover bioactive compounds from industrial by‑products or wastes, such as PLE, UAE, or SFC;
  • Innovative extraction techniques applied to recover bioactive compounds from industrial by products or wastes, such as extraction assisted by enzymes, pulsed electric fields (PEFs), etc.;
  • Optimization of extraction procedures through experimental design;
  • Purification procedures to obtain purer extracts or bioactive compounds;
  • Purification procedures to obtain more efficient bioactive extracts.

Prof. Dr. Juan Antonio Nieto
Prof. Mariana Silva López
Prof. Teodoro Suárez Diéguez
Guest Editors

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Keywords

  • natural products
  • purification
  • pressurized liquid extraction
  • supercritical fluid extractions
  • ultrasound-assisted extraction
  • advanced extraction
  • solid–liquid extraction
  • sistainable extraction
  • eutectic solvents

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Published Papers (2 papers)

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Research

18 pages, 5183 KiB  
Article
Enhanced Extraction of Tanshinones from Salvia miltiorrhiza Using Natural-Surfactant-Based Cloud Point Extraction
by Yerim Shin, Byeongryeol Ryu, Minji Kang, Minjun Kim and Jungdae Lim
Processes 2024, 12(10), 2227; https://doi.org/10.3390/pr12102227 - 12 Oct 2024
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Abstract
Salvia miltiorrhiza (SM) contains the tanshinones, a compound with various pharmacological effects, and has been extensively studied as a pharmaceutical material. However, conventional methods for extracting tanshinones face challenges such as environmental hazards and high cost. In this study, we aimed to effectively [...] Read more.
Salvia miltiorrhiza (SM) contains the tanshinones, a compound with various pharmacological effects, and has been extensively studied as a pharmaceutical material. However, conventional methods for extracting tanshinones face challenges such as environmental hazards and high cost. In this study, we aimed to effectively extract tanshinones from SM using cloud point extraction (CPE) with lecithin, a natural surfactant. By optimizing various extraction conditions including the solid-to-liquid ratio, lecithin concentration, NaCl concentration, pH, and equilibrium temperature, the optimal extraction efficiency was achieved using 20 mL of solvent per 1 g of sample, 3% lecithin (w/v), 2% NaCl (w/v), pH 6, and room temperature (25 ± 2 °C). The CPE method, which minimizes the use of organic solvent and is eco-friendly, demonstrated improvements in extraction efficiency, with a 4.55% increase for dihydrotanshinone I, 8.32% for cryptotanshinone, 15.77% for tanshinone I, and 6.81% for tanshinone IIA compared to the conventional water extraction method. These results suggest that CPE is a promising, environmentally friendly, and efficient approach for extracting hydrophobic components from pharmacologically active materials such as SM, with potential applications across various fields of natural product extraction. Full article
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11 pages, 1447 KiB  
Article
Assessment of Yield, Flavonoid and Phytosterol Contents, and Fatty Acid Composition of Baru Almond Oil (Dipteryx alata Vogel) by Supercritical CO2 Extraction
by Ana Carolina Ferreira, Guilherme Lopes, Antonio Carlos Filho, Najla Postaue, Celso Belisário, Leonardo Lataro Paim, Lúcio Cardozo-Filho, Camila da Silva, Leandro Ferreira-Pinto and Rogério Favareto
Processes 2024, 12(8), 1729; https://doi.org/10.3390/pr12081729 - 16 Aug 2024
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Abstract
The objective of this study was to investigate the influence of temperature and pressure on the extraction of Baru almond oil using pressurized CO2. From the obtained data, it was found that variations in pressure and temperature influenced the oil yield [...] Read more.
The objective of this study was to investigate the influence of temperature and pressure on the extraction of Baru almond oil using pressurized CO2. From the obtained data, it was found that variations in pressure and temperature influenced the oil yield and total amount of phytosterols. The maximum yield of Baru oil achieved was approximately 30%, obtained at a pressure of 28 MPa and 60 °C. The phytosterols identified were campesterol, stigmasterol, and β-sitosterol, with a maximum content of 169.5 ± 4.2 mg/100 g of oil obtained at 20 MPa and 60 °C. Among these, β-sitosterol was the most abundant, accounting for 60% of the total phytosterol content under all the experimental conditions. The flavonoid content in the extracts was also quantified, with the total flavonoid levels ranging between 255 and 275 mg/100 g of oil depending on the experimental conditions. The fatty acid profile of the extracted oil predominantly consisted of oleic (51%) and linoleic (28%) acids. Full article
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