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5.1
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Journals
Processes
Special Issues
New Research on Transition Metal Catalysis and Green Synthesis
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New Research on Transition Metal Catalysis and Green Synthesis

A special issue of Processes (ISSN 2227-9717). This special issue belongs to the section "Catalysis Enhanced Processes".

Deadline for manuscript submissions: closed (15 April 2024) | Viewed by 2786

Special Issue Editors

Dr. Liangliang Song

E-Mail Website
Guest Editor
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Interests: C-H activation; heterocycle synthesis; transition metal catalysis
Prof. Dr. Lingchao Cai

E-Mail Website
Guest Editor
College of Chemical Engineering, Nanjing Forestry University, Nanjing 210037, China
Interests: natural product synthesis; total synthesis; asymmetric catalysis
Prof. Dr. Liang-An Chen

E-Mail Website
Guest Editor
College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210097, China
Interests: organic synthesis; organometallic chemistry and catalysis

Special Issue Information

Dear Colleagues,

Transition metal-catalyzed cross-coupling and cyclization reactions have proved to be highly efficient and significant and are widely used in carbon–carbon and carbon–heteroatom bond formations in both academic and industrial settings. Recently, transition metal-catalyzed C-H functionalization has emerged as a powerful and straightforward strategy to construct diverse heterocycles with high atom- and step-economy. Considering the environmental impact of reaction processes and products, green synthesis is in demand. Atom- and step-economy, as well as reaction waste, should be considered. Metal-free strategies, heterogenous catalysis and the employment of H2O as a solvent have been achieved for the construction of carbon–carbon and carbon–heteroatom bonds, as well as various kinds of heterocycles.

This Special Issue on “New Research on Transition Metal Catalysis and Green Synthesis” seeks high quality studies focusing on the latest reactions of transition metal catalysis and green synthesis. Topics include, but are not limited to:

  • Transition metal-catalyzed C-H functionalization;
  • Transition metal-catalyzed cross-coupling and cyclization;
  • Metal-free synthesis of important organic molecules;
  • Transformation employing H2O as solvent.

Dr. Liangliang Song
Prof. Dr. Lingchao Cai
Prof. Dr. Liang-An Chen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Processes is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • transition metal
  • cross-coupling
  • C-H functionalization
  • green synthesis
  • sustainable chemistry

Published Papers (2 papers)

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Research

21 pages, 3095 KiB  
Article
Para-Hydroxy Ni(II)-POCOP Pincer Complexes as Modifiers on Carbon Paste Electrodes and Their Application in Methanol Electro-Oxidation in Alkaline Media
by Fabiola Hernández-García, Arturo T. Sanchez-Mora, Juan S. Serrano-García, Andrés Amaya-Florez, Luis A. Ortiz-Frade, Giaan A. Alvarez-Romero, J. Antonio Cruz-Navarro and David Morales-Morales
Processes 2024, 12(7), 1466; https://doi.org/10.3390/pr12071466 (registering DOI) - 13 Jul 2024
Viewed by 96
Abstract
The application of organometallic materials as anodes in fuel cell devices has experienced a notable increase in recent years. However, the use of POCOP pincer complexes remains scarcely explored despite their great relevance in catalysis. Thus, in this work, the electrocatalytic activity to [...] Read more.
The application of organometallic materials as anodes in fuel cell devices has experienced a notable increase in recent years. However, the use of POCOP pincer complexes remains scarcely explored despite their great relevance in catalysis. Thus, in this work, the electrocatalytic activity to methanol in alkaline media of three Ni(II)-based POCOP pincer complexes—[NiCl{C6H2-4-OH-2,6-(OPiPr2)2}] (a1), [NiCl{C6H2-4-OH-2,6-(OPtBu2)2}] (a2), and [NiCl{C6H2-4-OH-2,6-(OPPh2)2}] (a3)—will be discussed. The complexes were use as modifiers of carbon paste electrodes that were evaluated using cyclic voltammetry considering diverse factors, such as the absence and presence of MeOH, diverse proportions (% w/w) of the complex in the electrode, scan rate, and different MeOH concentrations. Results indicated the presence of a redox pair Ni(II)/Ni(III) with a quasi-reversible behavior in all complexes, the anodic peak currents of which were proportional to the increase in MeOH concentrations (0.05–0.3 mM), and their oxidation potentials varied in the function of the P-substituent in the Ni(II)-POCOPs backbone. Complex a1 exhibited the best current density (429.5 mA cm2 at 0.5 mM) compared to its analogs a2 and a3. The current intensity of all electrodes displays good stability, which remains—with slight changes—up to 100 s. Moreover, a comparison of their catalytic rate constants suggested a great activity in complex a1 (0.52 × 106 cm3 mol−1 s−1) compared to its analogues, implying a great activity in the electro-oxidation of MeOH. Hence, this work opens new opportunities for the electrochemical application of POCOPs complexes for future DMFCs development. Full article
(This article belongs to the Special Issue New Research on Transition Metal Catalysis and Green Synthesis)
17 pages, 4381 KiB  
Article
Indolyl-Derived 4H-Imidazoles: PASE Synthesis, Molecular Docking and In Vitro Cytotoxicity Assay
by Egor A. Nikiforov, Nailya F. Vaskina, Timofey D. Moseev, Mikhail V. Varaksin, Ilya I. Butorin, Vsevolod V. Melekhin, Maria D. Tokhtueva, Dmitrii G. Mazhukin, Alexsei Y. Tikhonov, Valery N. Charushin and Oleg N. Chupakhin
Processes 2023, 11(3), 846; https://doi.org/10.3390/pr11030846 - 12 Mar 2023
Cited by 2 | Viewed by 1862
Abstract
The strategy of the nucleophilic substitution of hydrogen (SNH) was first applied for the metal-free C-H/C-H coupling reactions of 4H-imidazole 3-oxides with indoles. As a result, a series of novel bifunctional azaheterocyclic derivatives were obtained in yields up [...] Read more.
The strategy of the nucleophilic substitution of hydrogen (SNH) was first applied for the metal-free C-H/C-H coupling reactions of 4H-imidazole 3-oxides with indoles. As a result, a series of novel bifunctional azaheterocyclic derivatives were obtained in yields up to 95%. In silico experiments on the molecular docking were performed to evaluate the binding possibility of the synthesized small azaheterocyclic molecules to the selected biotargets (BACE1, BChE, CK1δ, AChE) associated with the pathogenesis of neurodegenerative diseases. To assess the cytotoxicity for the synthesized compounds, a series of in vitro experiments were also carried out on healthy human embryo kidney cells (HEK-293). The leading compound bearing both 5-phenyl-4H-imidazole and 1-methyl-1H-indole moieties was defined as the prospective molecule possessing the lowest cytotoxicity (IC50 > 300 µM on HEK-293) and the highest binding energy in the protein–ligand complex (AChE, −13.57 kcal/mol). The developed compounds could be of particular interest in medicinal chemistry, particularly in the targeted design of small-molecule candidates for the treatment of neurodegenerative disorders. Full article
(This article belongs to the Special Issue New Research on Transition Metal Catalysis and Green Synthesis)
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