Striated Muscle Proteomics II

Dear Colleagues,

We warmly invite contributions that enhance our understanding regarding cardiac and skeletal muscle biology. Striated muscle is a fascinating tissue that exhibits profound plasticity in response to mechanical loading, nutrition, and exogenous agents. Skeletal muscle undergoes a complex developmental process that creates mature multinucleate fibres exhibiting a broad range of different phenotypes. In response to endurance exercise, muscle can more than double its mitochondrial content, whereas resistance exercise stimulates protein accretion and substantial myofibre hypertrophy. Interestingly, cardiac muscle is exposed to a continuous rhythmic workload, yet pathological and physiological stimuli result in discrete forms of cardiac hypertrophy.

Muscle is the target of monogenic diseases, including muscular dystrophies and complex polygenic diseases such as type 2 diabetes. Similarly, cardiomyopathies occur due to inherited or environmental factors and are often progressive processes that coincide with other complicated risk factors, such as low exercise capacity, hypertension and dyslipidaemia. Therefore, understanding the deterioration of cardiac performance is a particularly challenging area of research. Indeed, from adulthood to old-age, the natural decline in muscle mass and cardiac function negatively impact individuals’ functional independence and health-span.

Striated muscle is a technically challenging substrate for proteomic investigation, and so we also welcome methodological articles that aim to address muscle-specific issues. We hope this Special Issue will serve as a point of reference for burgeoning themes in striated muscle proteomics.

Prof. Dr. Jatin G Burniston
Guest Editor

Manuscript Submission Information

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