Proteomics Studies of Stem Cells

Dear Colleagues,

The 21st century is undoubtedly the time of the most intensive research on the topic of stem cells. Stem cells are commonly used in animal model studies (e.g., mouse, rat, rabbit, as well as dog, pig or goat), both those in the field of basic research and aiming to design new forms of targeted therapy. The basic animal model studies focus on the analysis of physiological and biochemical properties of stem cells, while clinical research searches for the best way of cell-based therapy administration, as well as their interaction with drugs and other cells and tissues of the organism. In vitro research continues to play an important role in the medicine, as preclinical and clinical trials are still associated with a high risk of post-treatment complications. Nevertheless, stem cell therapies are increasingly common in orthopedics and traumatology, plastic surgery, aesthetic medicine, and cosmetology.

Additionally, there have been some far more advanced studies on the biotechnology of stem cells in bird, fish (Danio rerio), or Caenorhabditis elegans embryos, as well as plants.

Despite increasing knowledge on the physiological properties of stem cells, a large number of genetic, molecular, and biochemical studies still needs to be conducted. The development of transcriptomic and proteomic techniques allows for complex discovery of stem cell properties. Proteomic analyses, from the simple Western blot to advanced methods of mass spectrometry, permit the discovery and detailed molecular identification of new protein markers, the structure and biochemical activity of which is key from the viewpoint of therapeutic properties of stem cells.

This Special Issue aims to present the results of studies concerning proteomic analyses in the field of human, animal and plant stem cell bioengineering.  

Dr. Bartosz Kempisty
Guest Editor

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• human stem cells
• animal stem cells
• plant stem cells
• stem cells therapy
• protein signaling pathways
• proteome assays
• mass spectrometry
• amino acids composition of proteins
• protein structure and enzyme activity
• biochemical properties of proteins