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Sustainable Use of Bioactive Compounds: Green Approaches Towards Healthier Outcomes

A special issue of Sustainability (ISSN 2071-1050). This special issue belongs to the section "Sustainable Chemical Engineering and Technology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 714

Special Issue Editors


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Guest Editor
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: green pharmaceutical chemistry; natural products analysis; environmental chemistry

E-Mail Website
Guest Editor
Department of Pharmacy, Faculty of Medicine, University of Novi Sad, 21000 Novi Sad, Serbia
Interests: green pharmaceutical chemistry; natural products analysis; molecular docking

Special Issue Information

Dear Colleagues,

Bioactive compounds possess significant therapeutic and nutritional potential with various pharmaceutical, food, and cosmetic applications. Sustainable use of bioactive compounds ensures a positive impact on the environment and, at the same time, on health outcomes. The United Nations’ primary sustainable goals have made green extraction techniques more and more relevant in promoting ecologically acceptable activities that do little or no harm to humans. Employing and optimizing green extraction techniques can maximize the yield of bioactive compounds while making the process more efficient, faster, energy-saving, and free from toxic organic solvents, resulting in bioactive compounds that are safer for consumption. By-products from plant processing, usually discarded as waste, represent promising sources of valuable bioactive compounds. Their utilization can minimize environmental impact while enhancing resource efficiency. In this context, this Special Issue aims to gather high-quality original research articles and review papers that contribute to understanding and advancing sustainable approaches in bioactive compounds. Papers including different research areas are welcome:

  • Green extraction technologies applied for the extraction of bioactive compounds from various matrices;
  • QSAR analysis of green solvents;
  • Impact of green solvents on nature and environmental risk assessment;
  • Pharmacological activity of green extracts;
  • Application of green extracts in the food and pharmaceutical industry.

Dr. Nevena Grujić-Letić
Dr. Emilia I. Gligoric
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Sustainability is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • green chemistry
  • bioactive compounds
  • sustainability
  • environmental chemistry
  • molecular docking

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Published Papers (1 paper)

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Research

16 pages, 1558 KiB  
Article
One-Pot Combined Hydrodistillation of Industrial Orange Peel Waste for Essential Oils and Pectin Recovery: A Multi-Objective Optimization Study
by Jacopo Paini, Giusi Midolo, Francesca Valenti and Gianluca Ottolina
Sustainability 2025, 17(1), 293; https://doi.org/10.3390/su17010293 - 3 Jan 2025
Viewed by 520
Abstract
Sustainable waste management for orange peel waste is a global concern that presents a concomitant opportunity. In this study, a combined process was developed to optimize the simultaneous recovery of pectin, essential oils, and sugars from industrial orange peel waste. The sequential recovery [...] Read more.
Sustainable waste management for orange peel waste is a global concern that presents a concomitant opportunity. In this study, a combined process was developed to optimize the simultaneous recovery of pectin, essential oils, and sugars from industrial orange peel waste. The sequential recovery process was used as a benchmark, while a one-pot combined process was optimized through the design of the experiments. A multi-objective desirability function was computed to maximize process performance while balancing opposing optimal conditions. The aim was to find a model able to confidently predict yields while reducing the process environmental footprint, potentially giving the necessary multi-product flexibility in modern biorefining. As a result, the combined process under optimal conditions, liquid-to-solid ratio of 2.5, pH value of 3.7, and residence time of 130 min, yielded 0.52% of essential oils and 11% of pectin on a dry basis. The environmental factor 18 is relevant to the fine chemicals industry, which is the target sector of this study. Finally, the process mass balance was calculated, demonstrating the opportunity to further enhance process environmental sustainability and efficiency by upgrading the resulting solid fraction. Full article
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