Oxidative Stress and Neurotoxicity Induced by Chemicals

Dear Colleagues,

Oxidative stress is a term used to describe the cytotoxic effects caused due to an imbalance between the generation of reactive oxygen/nitrogen species (ROS/RNS) or other free radicals and the capacity of cells to combat them. Compared to other physiological systems, the neurological system is particularly more susceptible to oxidative damage because of its high energy requirements, high oxygen consumption, the abundance of polyunsaturated fatty acids that are sensitive to free radicals, and low level of antioxidant scavengers. Numerous studies have compellingly indicated that oxidative stress is a key pathological factor in the emergence of a variety of neurological disorders. However, more research is required to clarify the mechanisms underlying oxidative stress-induced neurotoxicity.

Certain chemicals and/or their metabolites can directly mediate the formation of free radicals that may induce damage to biomolecules and result in the development of irreversible neurodegeneration and even death both in humans and animals. Thus, it is crucial to comprehend the precise molecular pathways underlying chemical-induced oxidative damage and neurotoxicity to create efficient treatments and cutting-edge therapeutic approaches for major neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and amyotrophic lateral sclerosis.

To better understand and ameliorate chemical-induced neurotoxicity, this Special Issue aims to compile cutting-edge original research and review articles that reveal new mechanistic pathways, potential therapeutic approaches, and neuroprotective agents, particularly focusing on oxidative stress and neurotoxicity caused by chemicals, as well as their metabolites.

It is intended that this Special Issue, entitled “Oxidative Stress and Neurotoxicity Induced by Chemicals”, will advance the discipline by increasing the scientific knowledge of the possible contribution of oxidative stress and chemical exposure to the etiology of neurological disorders both in the public and scientific domains.

Dr. Angela Maria Casaril
Prof. Dr. Syed Ibrahim Rizvi
Dr. Mahendra Pratap Singh
Dr. Mohd Sami Ur Rasheed
Guest Editors

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• neurotoxin
• reactive oxygen species
• free radicals
• antioxidants
• neuronal damage
• neurodegeneration
• neuroprotection