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Toxics
Special Issues
Biomonitoring and Exposure Assessment of Multiple Occupational Hazards
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Biomonitoring and Exposure Assessment of Multiple Occupational Hazards

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (28 February 2023) | Viewed by 5315

Special Issue Editors

Dr. Qifei Deng

E-Mail Website
Guest Editor
School of Public Health, Guangzhou Medical University, Guangzhou, China
Interests: occupational epidemiology; co-exposure; health risk assessment
Dr. Yunfeng Zou

E-Mail Website
Guest Editor
School of Public Health, Guangxi Medical University, Nanning, China
Interests: neurotoxicity; health risk assessment; environmental epidemiology
Dr. Piye Niu

E-Mail Website
Guest Editor
School of Public Health, Capital Medical University, Beijing, China
Interests: metals; toxic mechanisms; neurotoxicity

Special Issue Information

Dear Colleagues,

Occupational populations are always being co-exposed to multiple hazards in their working environments, such as toxins, noise, radiation, and work shift. However, previous studies have often focused on the exposure assessment, health risk assessment, and molecular mechanisms of a single hazard, resulting in substantial knowledge gaps regarding the extent of multiple simultaneous exposures in working environments. In recent years, the generally existent multiple hazards and their complex modes of interaction, which are considered to be part of the “exposome”, have started to attract extensive attention. However, biomonitoring and exposure assessments for the concurrent occupational hazards have faced multiple conceptual, methodological, and analytical challenges. Thus, this Special Issue aims to share new information on the biomonitoring and exposure assessment of multiple occupational hazards and to assess their co-exposure effects on workers’ health and the underlying mechanisms. Innovative articles responding to this issue should report original findings, reviews, and methods relevant to biomonitoring and exposure assessment of multiple hazards in occupational environments.

Dr. Qifei Deng
Dr. Yunfeng Zou
Dr. Piye Niu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • occupational hazards
  • co-exposure
  • biomonitoring
  • exposure assessment
  • health risk assessment
  • mechanisms of toxicity

Published Papers (2 papers)

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Research

13 pages, 314 KiB  
Article
Hematological Effects and Benchmark Doses of Long-Term Co-Exposure to Benzene, Toluene, and Xylenes in a Follow-Up Study on Petrochemical Workers
by Zhaorui Zhang, Xin Liu, Chaofan Guo, Xinjie Zhang, Yingying Zhang, Na Deng, Guanchao Lai, Aichu Yang, Yongshun Huang, Shanfeng Dang, Yanqun Zhu, Xiumei Xing, Yongmei Xiao and Qifei Deng
Toxics 2022, 10(9), 502; https://doi.org/10.3390/toxics10090502 - 28 Aug 2022
Cited by 9 | Viewed by 2228
Abstract
Benzene, toluene, and xylenes (BTX) commonly co-exist. Exposure to individual components and BTX-rich mixtures can induce hematological effects. However, the hematological effects of long-term exposure to BTX are still unclear, and respective reference levels based on empirical evidence should be developed. We conducted [...] Read more.
Benzene, toluene, and xylenes (BTX) commonly co-exist. Exposure to individual components and BTX-rich mixtures can induce hematological effects. However, the hematological effects of long-term exposure to BTX are still unclear, and respective reference levels based on empirical evidence should be developed. We conducted a follow-up study in BTX-exposed petrochemical workers. Long-term exposure levels were quantified by measuring cumulative exposure (CE). Generalized weighted quantile sum (WQS) regression models and Benchmark Dose (BMD) Software were used to evaluate their combined effects and calculate their BMDs, respectively. Many hematologic parameters were significantly decreased at the four-year follow-up (p < 0.05). We found positive associations of CE levels of benzene, toluene, and xylene with the decline in monocyte counts, lymphocyte counts, and hematocrit, respectively (β > 0.010, Ptrend < 0.05). These associations were stronger in subjects with higher baseline parameters, males, drinkers, or overweight subjects (Pinteraction < 0.05). BTX had positive combined effects on the decline in monocyte counts, red-blood-cell counts, and hemoglobin concentrations (Ptrend for WQS indices < 0.05). The estimated BMDs for CE levels of benzene, toluene, and xylene were 2.138, 1.449, and 2.937 mg/m3 × year, respectively. Our study demonstrated the hematological effects of long-term BTX co-exposure and developed 8h-RELs of about 0.01 ppm based on their hematological effects. Full article
(This article belongs to the Special Issue Biomonitoring and Exposure Assessment of Multiple Occupational Hazards)
19 pages, 4523 KiB  
Article
Lipidomics Profiles and Lipid Metabolite Biomarkers in Serum of Coal Workers’ Pneumoconiosis
by Zhangjian Chen, Jiaqi Shi, Yi Zhang, Jiahe Zhang, Shuqiang Li, Li Guan and Guang Jia
Toxics 2022, 10(9), 496; https://doi.org/10.3390/toxics10090496 - 26 Aug 2022
Cited by 7 | Viewed by 2595
Abstract
As a serious occupational pulmonary fibrosis disease, pneumoconiosis still lacks effective biomarkers. Previous studies suggest that pneumoconiosis may affect the body’s lipid metabolism. The purpose of this study was to explore lipidomics profiles and lipid metabolite biomarkers in the serum of coal workers’ [...] Read more.
As a serious occupational pulmonary fibrosis disease, pneumoconiosis still lacks effective biomarkers. Previous studies suggest that pneumoconiosis may affect the body’s lipid metabolism. The purpose of this study was to explore lipidomics profiles and lipid metabolite biomarkers in the serum of coal workers’ pneumoconiosis (CWP) by a population case-control study. A total of 150 CWP cases and 120 healthy controls from Beijing, China were included. Blood lipids were detected in serum biochemistry. Lipidomics was performed in serum samples for high-throughput detection of lipophilic metabolites. Serum high density lipoprotein cholesterol (HDL-C) decreased significantly in CWP cases. Lipidomics data found 131 differential lipid metabolites between the CWP case and control groups. Further, the top eight most important differential lipid metabolites were screened. They all belonged to differential metabolites of CWP at different stages. However, adjusting for potential confounding factors, only three of them were significantly related to CWP, including acylhexosylceramide (AHEXCER 43:5), diacylglycerol (DG 34:8) and dimethyl-phosphatidylethanolamine (DMPE 36:0|DMPE 18:0_18:0), of which good sensitivity and specificity were proven. The present study demonstrated that lipidomics profiles could change significantly in the serum of CWP patients and that the lipid metabolites represented by AHEXCER, DG and DMPE may be good biomarkers of CWP. Full article
(This article belongs to the Special Issue Biomonitoring and Exposure Assessment of Multiple Occupational Hazards)
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