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Toxics
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Toxic Mode of Action, Toxicity Testing, and Health Risks of...
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Toxic Mode of Action, Toxicity Testing, and Health Risks of Environmental Pollutants

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: 30 August 2024 | Viewed by 971

Special Issue Editors

Prof. Dr. Weiwei Zheng

E-Mail Website
Guest Editor
School of Public Health, Fudan University, Shanghai 200433, China
Interests: drinking water; risk assessment; environmental epidemiology; public health; health policy; environment pollution; endocrine disrupting chemicals; chemical mixture
Prof. Dr. Yuanyuan Ruan

E-Mail Website
Guest Editor
Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China
Interests: tumor glycobiology; signaling transduction; protein translation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Based on the new concepts and methods of toxicology in the 21st century, this issue aims to conduct research on the metabolic transformation, toxicity pathways, epigenetic regulation, biomarkers and toxicity mechanisms of a low-dose exposure to environmental pollutants at multiple levels, including molecular, cellular, animal and human levels. Moreover, it aims to conduct a systematic safety assessment study on the potential health hazards and mechanisms of action of new environmental pollutants in China, study the biological effects of potential hazardous substances such as new environmental pollutants, and explore the concepts and strategies for toxicological safety assessment and safety risk assessment.

Prof. Dr. Weiwei Zheng
Prof. Dr. Yuanyuan Ruan
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • mode of action
  • toxicity testing
  • health risks
  • risk assessment
  • environmental pollutants

Published Papers (1 paper)

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Research

17 pages, 7292 KiB  
Article
Natural Pyrethrin-Induced Oxidative Damage in Human Liver Cells through Nrf-2 Signaling Pathway
by Yun Yang, Xiaoyi Wei, Mengchao Ying, Haiyan Huang, Yijie Sha, Xinyu Hong, Ping Xiao and Gonghua Tao
Toxics 2024, 12(4), 258; https://doi.org/10.3390/toxics12040258 - 30 Mar 2024
Viewed by 791
Abstract
Natural pyrethrins (NPs), one kind of bio-pesticide, have been widely used in organic agriculture and ecological environment studies. Studies have shown that NPs may affect the metabolism of rat liver and human hepatocytes; nevertheless, the toxic effects of NPs on the liver and [...] Read more.
Natural pyrethrins (NPs), one kind of bio-pesticide, have been widely used in organic agriculture and ecological environment studies. Studies have shown that NPs may affect the metabolism of rat liver and human hepatocytes; nevertheless, the toxic effects of NPs on the liver and the related mechanisms are still incompletely understood. In this research, we utilized three types of human liver cells to investigate the mechanism of NPs’ induction of oxidative stress. The results showed that NPs exhibit noteworthy cytotoxic effects on human liver cells. These effects are characterized by the induction of LDH release, mitochondrial collapse, and an increased production of ROS and MDA content, subsequently activating the Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2- related factor 2 (Keap1/Nrf-2) pathway. The ROS inhibitor N-acetyl-L-cysteine (NAC) can alleviate ROS/Nrf2-mediated oxidative stress. In addition, the siRNA knockdown of Nrf-2 exacerbated the injury, including ROS production, and inhibited cell viability. In summary, the ROS-mediated Keap1/Nrf-2 pathway could be an important regulator of NP-induced damage in human liver cells, which further illustrates the hepatotoxicity of NPs and thereby contributes to the scientific basis for further exploration. Full article
(This article belongs to the Special Issue Toxic Mode of Action, Toxicity Testing, and Health Risks of Environmental Pollutants)
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