Human Biomonitoring, Genetic Susceptibility and Quantitative Analysis of Environmental Exposures

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Metals and Radioactive Substances".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 765

Special Issue Editor


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Guest Editor
Research Laboratory of Pharmaceutical Sciences (LAPESF), State University of Rio de Janeiro (UERJ), Rio de Janeiro 23070-200, Brazil
Interests: environmental pollutants; mercury; cadmium; toxicokinetic genes; toxicodynamic genes; genetic susceptibility; polymorphisms genetics; indigenous groups

Special Issue Information

Dear Colleagues,

The issue of global pollutants has risen high on the agenda of public health in recent years. Metals are a persistent and pervasive global health threat. Human exposure to metal occurs from environmental and occupational sources. Usually, metals are rapidly absorbed, distributed to all tissues, and slowly or not eliminated; therefore, metal exposure has been associated with several adverse health outcomes. Recently, genetic variations have been studied extensively as potential biomarkers of disease susceptibility, risk of developing disorders, and higher body levels of metals in exposed populations. With regard to global environmental pollutants and environmental exposures, the use of genetic variations in genetic testing may help in human biomonitoring to identify individuals at risk of early disease and/or with higher levels of these agents in the body. We aim for this Special Issue to help to expand and strengthen the capacity to identify individuals at higher risk of developing serious outcomes in exposed populations, to advance the detection of human biomonitoring in metal poisoning, to study metal toxicology, and to identify gene–environment interactions to explain how genes may influence the toxicokinetics and toxicodynamics of metals.

To assess the current state of knowledge on metal exposure and adverse health outcomes in humans, we welcome the submission of high-quality original research, reviews, new methodologies, or perspectives that critically advance our understanding of metal exposure in human health.

Dr. Jamila Perini
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • global pollutants
  • environmental exposure
  • metal exposure
  • metal poisoning
  • toxicokinetic
  • toxicodynamic
  • human biomonitoring
  • risk assessment
  • gene–environment interaction
  • genetic susceptibility

Published Papers (1 paper)

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Research

15 pages, 7085 KiB  
Article
The GSTP1 rs1695 Polymorphism Is Associated with Mercury Levels and Neurodevelopmental Delay in Indigenous Munduruku Children from the Brazilian Amazon
by Mayara Calixto da Silva, Paulo Cesar Basta, Cristina Barroso Hofer, Mirian Akiko Furutani de Oliveira, Joeseph William Kempton, Rogério Adas Ayres de Oliveira, Ana Claudia Santiago de Vasconcellos and Jamila Alessandra Perini
Toxics 2024, 12(6), 441; https://doi.org/10.3390/toxics12060441 - 19 Jun 2024
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Abstract
Genetic polymorphisms may influence mercury (Hg) toxicity. The aims of this study were to evaluate individual factors, such as the presence of the GSTP1 rs1695 polymorphism, associated with internal Hg dose and child neurodevelopment in indigenous people from the Brazilian Amazon chronically exposed [...] Read more.
Genetic polymorphisms may influence mercury (Hg) toxicity. The aims of this study were to evaluate individual factors, such as the presence of the GSTP1 rs1695 polymorphism, associated with internal Hg dose and child neurodevelopment in indigenous people from the Brazilian Amazon chronically exposed to Hg. Eighty-two indigenous children were clinically evaluated, hair Hg was measured, and the GSTP1 rs1695 polymorphism was genotyped. The mean age was 4.8 years, the median Hg was 5.5 µg/g, and 93.8% of children exceeded the safe limit (2.0 µg/g). Fish consumption was associated with Hg levels (p = 0.03). The GSTP1 rs1695 A>G polymorphism was in the Hardy–Weinberg equilibrium and the highest prevalence of the GSTP1 AA genotype (80%) was found in Sawré Aboy, which had the highest Hg levels (10 µg/g) among the studied villages. The Hg levels tended to increase over the years in males and in carriers of the GSTP1 AA genotype (0.69 µg/g and 0.86 µg/g, respectively). Nine children failed the neurodevelopmental test, all of whom had Hg > 2.0 µg/g, and 88.9% carried the GSTP1 AA or AG genotypes, previously associated with the highest internal Hg doses and neurocognitive disorders. The genetic counseling of this population is important to identify the individuals at greater risk for neurodevelopmental disorders resulting from chronic Hg exposure. Full article
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