Exposome: New Frontiers in Exposure Science

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 2116

Special Issue Editors


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Guest Editor
National Center for Toxicological Research, U.S. FDA, Jefferson, AR 72079, USA
Interests: pesticide exposure; obesity; endocannabinoids; microbial genetics; gut microbe; toxicology bioremediation
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Guest Editor
Department of Family Medicine, Michigan State University, 788 Service Road, Rm B117, East Lansing, MI 48824, USA
Interests: exposure science; toxic metals; biomonitoring; nanoparticles; environmental health

Special Issue Information

Dear Colleagues,

The profound understanding of the impacts of environmental exposures on human health requires accessing the exposome, or the totality of exposures. This Special Issue aims to push the frontiers of exposome science using innovative tools to capture environmental exposures and examine their influence on disease risk.

We welcome reviews and research articles utilizing novel methods and technologies to characterize the external exposome more comprehensively across biological matrices. Contributions should focus on expanding exposure assessment across priority areas such as air or water pollution, pesticides, lifestyle factors, diet, and socioeconomic environments. We also invite submissions exploring the health-protective effects of beneficial phytochemical exposures from dietary sources. Such research into the positive impacts of exposure can provide balance with studies focused on the detrimental effects. Examining windows of susceptibility and critical developmental periods for both positive and negative exposures is encouraged.

In congruence with our scholarly aspirations, we invite submissions integrating exposome research with epidemiology to elicit drug exposure–disease connections. Longitudinal cohort studies leveraging sensors, geospatial modeling, and other computational tools to analyze exposure–health links are of interest. Multi-omics approaches connecting external exposure to internal biomarkers have the potential to reveal biological pathways underlying various health effects.

We invite perspectives that evaluate opportunities and challenges in applying exposome science across exposure assessment, epidemiology, toxicology, and risk assessment. Together, contributions should demonstrate the shift from conventional exposure science to integrated exposome mapping.

Overall, this Special Issue aims to showcase improved tools and research integrating the exposome that can inform disease prevention and public health strategies. We look forward to your submissions on this new frontier in exposure science.

Dr. Sandeep Kondakala
Dr. Masako Morishita
Guest Editors

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Keywords

  • exposomes
  • toxicological assessment
  • environmental Pollutants
  • phytochemical exposure
  • drug exposures
  • pesticide exposures
  • high fat diets
  • multi-omics
  • computational models

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Published Papers (1 paper)

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15 pages, 4699 KiB  
Brief Report
Reduced Isocyanate Release Using a Waterproof, Resin-Based Cast Alternative Relative to Fiberglass Casts
by Kristen Stefanescu, Claire L. Timlin, Ashley S. Moy and Grzegorz Zapotoczny
Toxics 2023, 11(12), 1002; https://doi.org/10.3390/toxics11121002 - 8 Dec 2023
Cited by 1 | Viewed by 1805
Abstract
The effects of occupational isocyanate exposure range from asthma and contact dermatitis to neurotoxicity and cancer. Respiratory sensitization due to orthopedic cast application has been well documented. This study aims to compare the safety of standard-of-care fiberglass casts and a novel waterproof cast [...] Read more.
The effects of occupational isocyanate exposure range from asthma and contact dermatitis to neurotoxicity and cancer. Respiratory sensitization due to orthopedic cast application has been well documented. This study aims to compare the safety of standard-of-care fiberglass casts and a novel waterproof cast alternative by measuring the amount of isocyanate released during off-gassing over time. A 3D-printed arm simulator with comparable casing material amounts was placed in a sealed chamber. An isocyanate-sensing color-changing (SafeAir) tag was used to measure the levels of toxic exposure. Triplicate trials were conducted across all time periods (15 min, 1 h, and 24 h) and conditions. The bare arm simulator and freshly opened tags served as negative controls. Normalized pixel intensity indexes and isocyanate release estimates in ppb were derived from ImageJ-analyzed SafeAir tag photos. Fiberglass casts exhibited greater isocyanate release than both the waterproof alternative (p = 0.0002) and no-cast controls (p = 0.0006), particularly at 24 h. The waterproof alternative and no-cast control did not statistically differ (p = 0.1603). Therefore, the waterproof alternative released less isocyanate than the fiberglass casts. Waterproof cast alternatives may be safer than fiberglass by limiting medical professionals’ exposure to toxic isocyanates and, thus, decreasing their risk of suffering occupational asthma. Full article
(This article belongs to the Special Issue Exposome: New Frontiers in Exposure Science)
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