Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
4.5
3.9
Journals
Toxics
Special Issues
Exposure to Endocrine Disruptors and Risk of Metabolic Diseases
share announcement

Exposure to Endocrine Disruptors and Risk of Metabolic Diseases

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: 28 March 2025 | Viewed by 664

Special Issue Editors

Dr. Xiaoshan Liu

E-Mail Website
Guest Editor
Dongguan Key Laboratory of Environmental Medicine, School of Public Health, Guangdong Medical University, Guangdong 523808, China
Interests: adverse effects and underlying mechanisms of endocrine disruptors; toxicology; human diseases
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Yungang Liu

E-Mail
Guest Editor
School of Public Health, Southern Medical University, Guangzhou, China
Interests: metabolism-activated genotoxicity; health risk assessment; carcinogenesis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Endocrine-disrupting chemicals (EDCs) are chemical substances that have the potential to disrupt hormone production or activity. These chemicals range from dioxins to polychlorinated biphenyls, specific pesticides, and pharmaceuticals, as well as plasticizers, such as bisphenols and phthalates. So far, the endocrine-disrupting effects of these compounds have been studied to a certain degree. Recently, more and more studies have shown that they are relevant in metabolic diseases, but their metabolism toxicity, including their cellular, molecular, and genetic toxicity via activated nuclear receptors and the modulated expression of biotransformation enzymes, is not yet fully understood. Further investigation is required into the metabolic disrupting effects of endocrinal disruptors via interacting with intracellular macromoleculer targets, such as peroxisome proliferator-activated receptors, liver x-activated receptors, and pregnane X receptors, in various experimental models, including, but not limited to, cell cultures, intact animal models (preferably using relevant transgenic animals), and human subjects.

This Special Issue will focus on metabolic disrupting effects and underlying mechanisms in various biologic systems (experimental models), which will allow us to more comprehensively understand the metabolic disrupting effects of endocrinal disruptors.

We welcome submissions of original research articles, literature reviews, and short communications for this Special Issue.

Dr. Xiaoshan Liu
Prof. Dr. Yungang Liu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • endocrine disruptors
  • environmental toxicology
  • metabolism
  • molecular mechanism
  • reproductive and developmental toxicity

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

14 pages, 1622 KiB  
Article
The Association Between Brominated Flame Retardants Exposure and Liver-Related Biomarkers in US Adults
by Yuqing Chen, Yulan Cheng, Jialing Ruan, Donglei Huang, Jing Xiao, Xinyuan Zhao, Jinlong Li, Jianhua Qu and Xiaoke Wang
Toxics 2024, 12(12), 852; https://doi.org/10.3390/toxics12120852 - 26 Nov 2024
Viewed by 487
Abstract
Background: Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. Methods: To further explore the association between BFR exposure [...] Read more.
Background: Emerging studies demonstrate that exposure to brominated flame retardants (BFRs) can have harmful effects on human health. Our study focused on the relationship between exposure to various BFRs and markers of liver function. Methods: To further explore the association between BFR exposure and liver function impairment, we used data from the National Health and Nutrition Examination Surveys (NHANES) for three cycles from 2009 to 2014, leaving 4206 participants (≥20 years of age) after screening. Nine BFRs and eight liver function tests (LFTs) were measured in the participants’ serum to represent BFRs and liver function impairment in vivo. To investigate whether there is a relationship between BFRs and health outcome, statistical research methods such as the weighted linear regression model, restricted cubic spline (RCS), weighted quantile sum (WQS), quantile-based g computing (QGC), and the Bayesian Kernel Machine Regression (BKMR) were used to evaluate the correlation between serum BFRs and LFTs. Results: The studies reveals that exposure to BFRs is associated with liver function biomarkers. In a weighted linear regression model, we found that PBB153, PBDE99, PBDE154, PBDE209, PBDE85 exposure was positively correlated with AST, ALT, GGT, ALP, TP, and SL risk. In RCS model, the nonlinear relationships between PBB153 and AST, ALT, and GGT and PBDE209 and ALT and TP are the most significant. The exposure to combined BFRs was positively correlated with AST, ALT, and GGT in WQS and QGC models. BKMR analysis showed that BFR exposure was positively correlated with AST, ALT, ALP, and GGT. Conclusions: Exposure to BFRs is associated with liver function impairment, suggesting that BFR exposure is potentially toxic to the human liver, but more in-depth studies are needed to explore this correlation. Full article
(This article belongs to the Special Issue Exposure to Endocrine Disruptors and Risk of Metabolic Diseases)
►▼ Show Figures

Figure 1

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop