Exposure to Endocrine Disruptors and Risk of Metabolic Diseases
A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".
Deadline for manuscript submissions: 28 March 2025 | Viewed by 26
Special Issue Editors
Interests: adverse effects and underlying mechanisms of endocrine disruptors; toxicology; human diseases
Special Issues, Collections and Topics in MDPI journals
Interests: metabolism-activated genotoxicity; health risk assessment; carcinogenesis
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Endocrine-disrupting chemicals (EDCs) are chemical substances that have the potential to disrupt hormone production or activity. These chemicals range from dioxins to polychlorinated biphenyls, specific pesticides, and pharmaceuticals, as well as plasticizers, such as bisphenols and phthalates. So far, the endocrine-disrupting effects of these compounds have been studied to a certain degree. Recently, more and more studies have shown that they are relevant in metabolic diseases, but their metabolism toxicity, including their cellular, molecular, and genetic toxicity via activated nuclear receptors and the modulated expression of biotransformation enzymes, is not yet fully understood. Further investigation is required into the metabolic disrupting effects of endocrinal disruptors via interacting with intracellular macromoleculer targets, such as peroxisome proliferator-activated receptors, liver x-activated receptors, and pregnane X receptors, in various experimental models, including, but not limited to, cell cultures, intact animal models (preferably using relevant transgenic animals), and human subjects.
This Special Issue will focus on metabolic disrupting effects and underlying mechanisms in various biologic systems (experimental models), which will allow us to more comprehensively understand the metabolic disrupting effects of endocrinal disruptors.
We welcome submissions of original research articles, literature reviews, and short communications for this Special Issue.
Dr. Xiaoshan Liu
Prof. Dr. Yungang Liu
Guest Editors
Manuscript Submission Information
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Keywords
- endocrine disruptors
- environmental toxicology
- metabolism
- molecular mechanism
- reproductive and developmental toxicity
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