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Toxics
Special Issues
Quantification, Risk Assessment and Body Exposure Levels of Toxic Substances
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Quantification, Risk Assessment and Body Exposure Levels of Toxic Substances

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Exposome Analysis and Risk Assessment".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 5433

Special Issue Editors

Dr. Yaqin Ji

E-Mail Website
Guest Editor
State Environmental Protection Key Laboratory of Urban Ambient Air Particulate Matter Pollution Prevention and Control, Tianjin, China
Interests: environmental health; source apportionment; emission inventory
Dr. Penghui Li

E-Mail Website
Guest Editor
School of Environmental Science and Safety Engineering, Tianjin University of Technology
Interests: environmental pollutants; environmental health effects; environmental modeling
Special Issues, Collections and Topics in MDPI journals
Dr. Liqiong Guo

E-Mail Website
Guest Editor
Institute of Disaster Medicine, Tianjin University, Tianjin, China
Interests: In vitro diagnostic technology research; disease risk prediction; molecular epidemiology of disasters; environmental epigenetics
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Environmental contaminants and related human health risks have become a global environmental issue. Environmental contaminants enter an ecosystem and spread throughout the food chain. The potential exposure of humans to these contaminants is a serious concern. In recent years, there has been a growing interest in the relationship between environmental contaminants and human diseases, in an attempt to answer the question of how the contaminants affect human bodies.

This Special Issue focuses on environmental contaminants and human health, aiming to elucidate the relationship and mechanisms. It covers, but is not limited to, the following topics: the occurrence levels of contaminants in environmental and human bodies, exposure estimation, toxicity research, meta-analysis and review of data.

Dr. Yaqin Ji
Dr. Penghui Li
Dr. Liqiong Guo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • environmental contaminants
  • exposure
  • health effects
  • risk estimation
  • toxicological effect

Published Papers (3 papers)

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Research

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12 pages, 511 KiB  
Article
The Levels of Polycyclic Aromatic Hydrocarbons and Their Derivatives in Plasma and Their Effect on Mitochondrial DNA Methylation in the Oilfield Workers
by Yaning Jia, Weixia Li, Yanlin Li, Lei Zhao, Chenguang Li, Lei Wang, Junkai Fang, Shanjun Song, Yaqin Ji, Tao Fang, Jing Zhang, Liqiong Guo and Penghui Li
Toxics 2023, 11(5), 466; https://doi.org/10.3390/toxics11050466 - 17 May 2023
Cited by 3 | Viewed by 1410
Abstract
This study focuses on the components and levels of polycyclic aromatic hydrocarbons (PAHs) and their derivatives (MPAHs and OPAHs) in plasma samples from 19 oil workers, pre- and post-workshift, and their exposure–response relationship with mitochondrial DNA (mtDNA) methylation. PAH, MPAH, OPAH, and platelet [...] Read more.
This study focuses on the components and levels of polycyclic aromatic hydrocarbons (PAHs) and their derivatives (MPAHs and OPAHs) in plasma samples from 19 oil workers, pre- and post-workshift, and their exposure–response relationship with mitochondrial DNA (mtDNA) methylation. PAH, MPAH, OPAH, and platelet mtDNA methylation levels were determined using a gas chromatograph mass spectrometer (GC-MS) and a pyrosequencing protocol, respectively. The total plasma concentrations of PAHs in mean value were, respectively, 31.4 ng/mL and 48.6 ng/mL in pre- and post-workshift, and Phe was the most abundant (13.3 ng/mL in pre-workshift and 22.1 ng/mL in post-workshift, mean value). The mean values of total concentrations of MPAHs and OPAHs in the pre-workshift were 2.7 ng/mL and 7.2 ng/mL, while in the post-workshift, they were 4.5 ng/mL and 8.7 ng/mL, respectively. The differences in the mean MT-COX1, MT-COX2, and MT-COX3 methylation levels between pre- and post-workshift were 2.36%, 5.34%, and 0.56%. Significant (p < 0.05) exposure–response relationships were found between PAHs and mtDNA methylation in the plasma of workers; exposure to Anthracene (Ant) could induce the up-regulation of the methylation of MT-COX1 (β = 0.831, SD = 0.105, p < 0.05), and exposure to Fluorene (Flo) and Phenanthrene (Phe) could induce the up-regulation of methylation of MT-COX3 (β = 0.115, SD = 0.042, p < 0.05 and β = 0.036, SD = 0.015, p < 0.05, respectively). The results indicated that exposure to PAHs was an independent factor influencing mtDNA methylation. Full article
(This article belongs to the Special Issue Quantification, Risk Assessment and Body Exposure Levels of Toxic Substances)
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Review

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23 pages, 1057 KiB  
Review
Radiation-Induced Intestinal Injury: Injury Mechanism and Potential Treatment Strategies
by Qianying Lu, Yangfan Liang, Sijia Tian, Jie Jin, Yanmei Zhao and Haojun Fan
Toxics 2023, 11(12), 1011; https://doi.org/10.3390/toxics11121011 - 10 Dec 2023
Viewed by 1949
Abstract
Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute RIII is essentially symptomatic and nutritional support treatment [...] Read more.
Radiation-induced intestinal injury (RIII) is one of the most common intestinal complications caused by radiotherapy for pelvic and abdominal tumors and it seriously affects the quality of life of patients. However, the treatment of acute RIII is essentially symptomatic and nutritional support treatment and an ideal means of prevention and treatment is lacking. Researchers have conducted studies at the cellular and animal levels and found that some chemical or biological agents have good therapeutic effects on RIII and may be used as potential candidates for clinical treatment. This article reviews the injury mechanism and potential treatment strategies based on cellular and animal experiments to provide new ideas for the diagnosis and treatment of RIII in clinical settings. Full article
(This article belongs to the Special Issue Quantification, Risk Assessment and Body Exposure Levels of Toxic Substances)
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18 pages, 3555 KiB  
Review
The Associations between Organophosphate Pesticides (OPs) and Respiratory Disease, Diabetes Mellitus, and Cardiovascular Disease: A Review and Meta-Analysis of Observational Studies
by Lei Zhao, Qisijing Liu, Yaning Jia, Huishu Lin, Yuanyuan Yu, Xuemei Chen, Ziquan Liu, Weixia Li, Tao Fang, Wenbing Jiang, Jianfeng Zhang, Huanhuan Cui, Penghui Li, Hongyu Li, Shike Hou and Liqiong Guo
Toxics 2023, 11(9), 741; https://doi.org/10.3390/toxics11090741 - 30 Aug 2023
Cited by 3 | Viewed by 1711
Abstract
Although some epidemiological studies have identified the associations between exposure to organophosphate pesticides (Ops) and respiratory diseases, diabetes mellitus (DM), and cardiovascular diseases (CVDs), controversial results still exist. In this review and meta-analysis, we aimed to investigate the overall pooled effect estimates and [...] Read more.
Although some epidemiological studies have identified the associations between exposure to organophosphate pesticides (Ops) and respiratory diseases, diabetes mellitus (DM), and cardiovascular diseases (CVDs), controversial results still exist. In this review and meta-analysis, we aimed to investigate the overall pooled effect estimates and the possible mechanisms of the relationship between OP exposure and adverse health outcomes. In this study, Web of Science, PubMed, Embase, OVID, and the Cochrane Library were systematically searched until September 2022. Nineteen observational studies that focused on the general population or occupational populations examined the associations between OP exposure and respiratory diseases, DM, and CVD were included. Based on the overall pooled results, a significantly positive association was observed between OP exposure and respiratory diseases (OR: 1.12, 95% CI: 1.06–1.19). A significant link was also observed between various individual species of OP exposure and respiratory diseases, with an OR value of 1.11 (95% CI: 1.05–1.18). In particular, there was a significant association of OPs with wheezing and asthma, with OR values of 1.19 (95% CI: 1.08–1.31) and 1.13 (95% CI: 1.05–1.22), respectively. In addition, a significant association was also observed between OP exposure and DM (OR: 1.18, 95% CI: 1.07–1.29). However, no significant association was observed between OP exposure and CVD (OR: 1.00, 95% CI: 0.94–1.05). Exposure to OPs was associated with a significantly increased risk of respiratory diseases and DM, but there was no evidence of a significant association between OP exposure and CVD. Considering the moderate strength of the results, further evidence is needed to confirm these associations. Full article
(This article belongs to the Special Issue Quantification, Risk Assessment and Body Exposure Levels of Toxic Substances)
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