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Toxics
Special Issues
Effects of Ozone on Cardiovascular Diseases
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Effects of Ozone on Cardiovascular Diseases

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Air Pollution and Health".

Deadline for manuscript submissions: 29 November 2024 | Viewed by 239

Special Issue Editor

Dr. Jianbing Wang

E-Mail Website
Guest Editor
School of Public Health, Zhejiang University, Hangzhou, China
Interests: environmental epidemiology; air pollution; cardiovascular disease; risk factors; cohort study
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Ground-level ozone, one of the main air pollutants, is a serious issue and has received increased attention in recent decades. Different from other pollutants, ozone is not directly emitted into the air from specific sources; it is generated by nitrogen oxides (NOx) and volatile organic compounds (VOCs), in the presence of ultraviolet (UV) rays. This means that ozone is a secondary pollutant. The Global Burden of Disease Study 2021 indicates that the risk attributable to DALYs for ambient ozone pollution increased between 2000 and 2021, with the risk value reaching 8·8 (1·9 to 15·0) million in 2021. Ambient ozone mainly enters the human body through inhalation via the respiratory tract, with a smaller portion also being absorbed through the digestive tract and skin. Due to high oxidizing, ozone can cause immune–inflammatory responses that not only damage the respiratory system but also the circulatory system. Recently, more and more studies have shown that exposure to ambient ozone has adverse effects on cardiovascular diseases, including coronary heart disease, arrhythmia, ischemic stroke, and so on. Furthermore, due to the development of new technologies such as multi-omics, the possible mechanisms by which ambient ozone causes diseases are being explored.

For the present Special Issue, we would like to collect original studies, systematic reviews, and short communications on ambient ozone exposure and cardiovascular diseases, including but not limited to ecological studies, case-crossover studies, and cohort studies.

Dr. Jianbing Wang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ozone
  • cardiovascular diseases
  • cohort study
  • ecological study
  • case-crossover study
  • environmental epidemiology

Published Papers (1 paper)

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Research

11 pages, 1140 KiB  
Article
Short-Term Interaction Effects of PM2.5 and O3 on Daily Mortality: A Time-Series Study of Multiple Cities in China
by Ying Zhang, Lingling Fan, Shigong Wang and Huan Luo
Toxics 2024, 12(8), 578; https://doi.org/10.3390/toxics12080578 (registering DOI) - 8 Aug 2024
Abstract
In recent years, PM2.5 and O3 have been the two main pollutants affecting public health in China, but the interaction of the two pollutants on human health remains unclear. A two-stage analytical approach was used to investigate the relationships of PM [...] Read more.
In recent years, PM2.5 and O3 have been the two main pollutants affecting public health in China, but the interaction of the two pollutants on human health remains unclear. A two-stage analytical approach was used to investigate the relationships of PM2.5–O3 co-pollution with nonaccidental, cardiovascular, and respiratory mortality levels across 14 cities in China. We first utilized a generalized additive model (GAM) to determine the city-specific associations of PM2.5 and O3 with daily mortality. The associations were then combined at the national and regional levels using meta-analysis. To investigate the potential interactions between the two pollutants and cause-specific mortality, we performed stratified analyses by co-pollutant exposure levels and the synergy index (SI) (SI > 1 indicates a synergistic interaction). The effect of changes in the two pollutants’ concentrations (in 10 μg/m3 increases) on mortality was assessed. The stratification analysis results suggested that each 10 μg/m3 increase in PM2.5 at lag0-1 (lag01) in the low, moderate, and high strata of the O3 concentrations increased nonaccidental mortality by 0.07% (95% confidence interval: −0.03%, 0.17%), 0.33% (0.13%, 0.53%), and 0.68% (0.30%, 1.06%), respectively, with significant between-group differences (p < 0.001). Moreover, each 10 μg/m3 increase in O3 (lag01) in the low, moderate, and high strata of the PM2.5 concentrations increased nonaccidental mortality by 0.15% (−0.06%, 0.36%), 0.53% (0.19%, 0.87%), and 0.75% (0.14%, 1.36%), respectively, with significant between-group differences (p < 0.001). We also found substantial synergistic interactions between the two pollutants and nonaccidental, cardiovascular, and respiratory mortality levels, with SI values of 1.48, 1.51, and 1.33, respectively. Additionally, a subgroup analysis revealed that the interaction of these two pollutants on nonaccidental mortality were greater in South China compared to elsewhere, and during the warm season compared to during the cold season. Our findings suggested that the simultaneous control of PM2.5 and O3 within the context of combined air pollution could significantly decrease the disease risk, especially in southern China and during the warm season. Full article
(This article belongs to the Special Issue Effects of Ozone on Cardiovascular Diseases)
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