PFAS Toxicology and Metabolism

Dear Colleagues,

Per- and polyfluoroalkyl substances (PFAS) are seemingly everywhere: in our bodies, homes, clothes, food packaging, drinking water, rivers, soils, and carried across the globe in the atmosphere. Yet, despite their widespread occurrence and detection of a growing number of compounds, we know very little about the risks posed by our own and the environment’s exposure to these long-lived chemicals. Multiple studies have been published on the health effects of the first known PFAS, perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS), but there are gaps in the data for other legacy and emerging chemicals in this structurally diverse class. Additionally, since we are likely exposed to multiple PFAS simultaneously, gaining an understanding of the potentially toxic effects of mixtures represents another critical data gap to fill.

This Special Issue of Toxics aims to expand knowledge of the health effects of per- and polyfluoroalkyl substances. We welcome original research, new methodologies and protocols, and reviews that evaluate the exposure, hazard, metabolism, and fate of legacy and emerging PFAS, PFAS mixtures, and resulting effects to humans and other organisms. Research may include in vivo, in vitro, and in silico studies in areas including, but not limited to, PFAS biomonitoring, bioaccumulation, biotransformation, dosimetry, exposure, toxicokinetics, lipidomics, metabolomics, integrated omics, neurotoxicity, endocrine disruption, developmental and reproductive toxicology, and cancer. In vivo dose–response studies that evaluate health effects related to sub-chronic and chronic exposure at environmentally relevant levels are welcome, as are those that employ new approach methodologies (NAMs), such as in vitro screening, microphysiologic systems, adverse outcome pathways, in vitro–in vivo extrapolation (IVIVE), computational modeling or other approaches.

Dr. Denise MacMillan
Dr. Barbara Wetmore
Prof. Dr. William S. Baldwin
Dr. Subham Dasgupta
Guest Editors

Manuscript Submission Information

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