Immune Strategies and Vaccine Development against Veterinary Virus Infection

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Veterinary Vaccines".

Deadline for manuscript submissions: 28 February 2025 | Viewed by 1286

Special Issue Editors


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Guest Editor
Human Health Therapeutics, National Research Council Canada, 100 Sussex Dr., Ottawa, ON K1A 0R6, Canada
Interests: host immune responses; virus–host interactions; immunogenicity of vaccines; mucosal immunity; pathogenesis; trained immunity; infectious diseases
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Guest Editor
National Centre for Foreign Animal Disease, Canadian Food Inspection Agency, 1015 Arlington St., Winnipeg, MB R3E 3P6, Canada
Interests: influenza immunology; innate immune responses; vaccines; adjuvants; mucosal immunity

Special Issue Information

Dear Colleagues,

The spread of animal viruses due to changes in the environment not only affects the health and performance of the animals but also significantly impacts animal food production. Some viruses have zoonotic potential and pose a threat to human health as well. In addition, the continued evolution of viral pathogens and the emergence of new variants challenge the effectiveness of vaccination strategies in practice. To combat emerging infectious viral diseases and develop vaccine strategies against novel viruses to employ control and preventive measures, clear insight into the host immune responses against viral pathogens in animals and vaccines is essential. Current research in viral infectious diseases using cutting-edge technologies and novel approaches helps us to understand the mechanisms of immune responses of vaccines and viral pathogens in animal species. 

This Special Issue focuses on recent research progress in vaccine development, immune strategies, host immune responses, and host–virus interaction in livestock and companion animals. It will provide an opportunity to share evolving knowledge on veterinary immunology and vaccinology of infectious diseases to scholars working in this area. This Special Issue will also consider the developing knowledge on the unexplored area of host–virus interaction for potential intervention methodologies and other immune-related aspects of veterinary viruses. 

For this Special Issue of Vaccines, original research articles, reviews and systematic reviews are welcome for submission. Research areas include, but are not limited to, the immune responses to viral infections of veterinary interest, the development of vaccines, vaccine adjuvants, vaccine delivery systems, vaccine responses in the host, and novel approaches to induce protective innate and adaptive immune responses in the host. We look forward to receiving your contributions.

Dr. Jegarubee Bavananthasivam
Dr. Tamiru Alkie
Guest Editors

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Keywords

  • viral infection
  • infectious diseases
  • immune responses
  • vaccines
  • livestock
  • companion animals

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Published Papers (1 paper)

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Research

18 pages, 3471 KiB  
Article
Evaluation of the Safety and Immunogenicity of a Multiple Epitope Polypeptide from Canine Distemper Virus (CDV) in Mice
by Santiago Rendon-Marin, Daniel-Santiago Rincón-Tabares, Jorge H. Tabares-Guevara, Natalia Arbeláez, Jorge E. Forero-Duarte, Francisco J. Díaz, Sara M. Robledo, Juan C. Hernandez and Julian Ruiz-Saenz
Vaccines 2024, 12(10), 1140; https://doi.org/10.3390/vaccines12101140 - 4 Oct 2024
Viewed by 739
Abstract
Background: Morbillivirus canis is the etiological agent of a highly contagious disease that affects diverse domestic and wild animals. Vaccination is considered the most suitable strategy for controlling CDV dissemination, transmission, and distemper disease. However, the emergence of new CDV strains has led [...] Read more.
Background: Morbillivirus canis is the etiological agent of a highly contagious disease that affects diverse domestic and wild animals. Vaccination is considered the most suitable strategy for controlling CDV dissemination, transmission, and distemper disease. However, the emergence of new CDV strains has led to the need to update the current vaccine strategies employed to prevent CDV infection in domestic and wild animals. Currently, there is a lack of effective alternatives for wild animals. Diverse computational tools, especially peptide-based therapies, enable the development of new universal vaccines. Objective: The aim of this study was to evaluate the safety and humoral and cellular immune response of a new generation of vaccines based on CDV peptides as single-peptide mixtures or multiepitope CDV polypeptides in mice. Methods: Twenty-four BALB/c mice were subjected to a three-dose regimen for 28 days. Seroconversion was evaluated via ELISA, and cellular immune responses were evaluated via flow cytometry through activation-induced markers (AIMs). Results: Compared with the placebo, the peptide mixture and multiepitope CDV polypeptide were safe, and seroconversion was statistically significant in the multiepitope CDV polypeptide and commercial vaccine (CV) groups. The numbers of antigen-specific CD4+CD134+ and IFN-γ+ T cells, CD8+ T cells and TNF-α- and IL-6-producing cells were greater in the mice immunized with the multiepitope CDV polypeptide than in the control mice. Conclusion: This combined approach represents a potential step forward in developing new immunization candidates or enhancing current commercial vaccines to control CDV disease in domestic dogs and wild animals. Full article
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