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Vaccines
Special Issues
Pharmacoepidemiology in Vaccine Safety and Efficacy
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Pharmacoepidemiology in Vaccine Safety and Efficacy

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Efficacy and Safety".

Deadline for manuscript submissions: 31 January 2025 | Viewed by 1557

Special Issue Editors

Dr. Chao-Min Cheng

E-Mail Website
Guest Editor
Institute of Biomedical Engineering, National Tsing Hua University, Hsinchu City 300, Taiwan
Interests: biomedical engineering; diagnostic methods; vaccines
Special Issues, Collections and Topics in MDPI journals
Dr. Ching-Fen Shen

E-Mail Website
Guest Editor
Department of Pediatrics, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan
Interests: infectious diseases; pediatrics; translational medicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The pharmacoepidemiology of vaccines provides near-real-time monitoring and scientific information for evidence-based decision-making. The field involves assessing the risks and benefits associated with vaccination programs, which includes monitoring adverse events following vaccination, evaluating vaccine effectiveness in preventing disease, and studying factors that influence vaccine uptake and effectiveness. This field provides evidence-based information to guide decision-making regarding vaccine development, recommendations, and implementation strategies. We are inviting original articles, review articles, brief communications, and case reports related to "Pharmacoepidemiology in Vaccine Safety and Efficacy" for this Special Issue.

Dr. Chao-Min Cheng
Dr. Ching-Fen Shen
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pharmacoepidemiology
  • safety
  • efficacy
  • vaccines

Published Papers (1 paper)

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Research

24 pages, 9238 KiB  
Article
COVID-19 Vaccination in Pregnancy: Pilot Study of Plasma MicroRNAs Associated with Inflammatory Cytokines after COVID-19 mRNA Vaccination
by Ching-Ju Shen, Yen-Pin Lin, Wei-Chun Chen, Mei-Hsiu Cheng, Jun-Jie Hong, Shu-Yu Hu, Ching-Fen Shen and Chao-Min Cheng
Vaccines 2024, 12(6), 658; https://doi.org/10.3390/vaccines12060658 - 14 Jun 2024
Viewed by 1347
Abstract
Background: The impact of mRNA COVID-19 vaccines on the immunological profiles of pregnant women remains a crucial area of study. This research aims to explore the specific immunological changes triggered by these vaccines in this demographic. Methods: In a focused investigation, we examined [...] Read more.
Background: The impact of mRNA COVID-19 vaccines on the immunological profiles of pregnant women remains a crucial area of study. This research aims to explore the specific immunological changes triggered by these vaccines in this demographic. Methods: In a focused investigation, we examined the effects of mRNA COVID-19 vaccination on microRNA expression in pregnant women. Key microRNAs, including miR-451a, miR-23a-3p, and miR-21-5p, were analyzed for expression changes post-vaccination. Additionally, we assessed variations in S1RBD IgG levels and specific cytokines to gauge the broader immunological response. Results: Post-vaccination, significant expression shifts in the targeted microRNAs were observed. Alongside these changes, we noted alterations in S1RBD IgG and various cytokines, indicating an adapted inflammatory response. Notably, these immunological markers displayed no direct correlation with S1RBD IgG concentrations, suggesting a complex interaction between the vaccine and the immune system in pregnant women. Conclusions: Our pilot study provides valuable insights into the nuanced effects of the mRNA COVID-19 vaccine on immune dynamics in pregnant women, particularly emphasizing the role of microRNAs. The findings illuminate the intricate interplay between vaccines, microRNAs, and immune responses, enhancing our understanding of these relationships in the context of pregnancy. This research contributes significantly to the growing body of knowledge regarding mRNA COVID-19 vaccines and their specific impact on maternal immunology, offering a foundation for further studies in this vital area. Full article
(This article belongs to the Special Issue Pharmacoepidemiology in Vaccine Safety and Efficacy)
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