Parasitic Infections: Therapy for Host Immunity and Vaccination

A special issue of Vaccines (ISSN 2076-393X).

Deadline for manuscript submissions: 30 November 2024 | Viewed by 788

Special Issue Editors


E-Mail Website
Guest Editor
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Gran Canaria, Spain
Interests: immunology, treatment and control of coccidiosis and gastrointestinal nematodes in small ruminants

E-Mail Website
Guest Editor
Department of Animal Pathology, Faculty of Veterinary Medicine, University of Las Palmas de Gran Canaria, Gran Canaria, Spain
Interests: immunology, treatment and control of coccidiosis and gastrointestinal nematodes in small ruminants

Special Issue Information

Dear Colleagues,

Over the last few decades, there has been extensive research into pharmaceutical alternatives to deal with adverse effects caused by parasites in humans and animals. This is mainly due to the development of resistance to antiparasitic drugs and the ecological problems associated with pharmacological residues in the environment and animal products for human consumption. However, there are still very few tools available to address more complex parasitic groups, such as helminths and arthropods. Many alternative strategies focus on enhancing the immune response of hosts to reduce parasite development. However, the results have not always been as expected, possibly due to the complexity of host–parasite interactions and environmental involvement.

We welcome original manuscripts, reviews, brief communications, meta-analyses, and other types of articles reporting vaccination and therapy trials against parasites for a Special Issue in Vaccines. We encourage the analysis of immune mechanisms against parasites and the relationship between protection and antiparasitic control strategies.

Prof. Dr. José Manuel Molina Caballero
Dr. Antonio Ruiz Reyes
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Vaccines is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • immune response
  • parasites
  • helminths
  • arthropods
  • protozoa
  • therapy
  • vaccination

Published Papers (1 paper)

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Research

15 pages, 2259 KiB  
Article
Analysis of Protection and Immune Response against Teladorsagia circumcincta in Goats Immunised with Thiol-Binding Proteins from Adult Worms
by Leire Ortega, Jessica Quesada, Antonio Ruiz, Magnolia María Conde-Felipe, Otilia Ferrer, María del Carmen Muñoz, José Adrián Molina, Francisco Rodríguez and José Manuel Molina
Vaccines 2024, 12(4), 437; https://doi.org/10.3390/vaccines12040437 - 18 Apr 2024
Viewed by 520
Abstract
In view of the increasing occurrence of anthelmintic-resistant strains of gastrointestinal nematodes in ruminants, various alternative control strategies have been investigated, such as those based on the induction of protective immune responses by immunisation with parasite antigens. In this study, the protective activity [...] Read more.
In view of the increasing occurrence of anthelmintic-resistant strains of gastrointestinal nematodes in ruminants, various alternative control strategies have been investigated, such as those based on the induction of protective immune responses by immunisation with parasite antigens. In this study, the protective activity of somatic antigens from adult worms of Teladorsagia circumcincta purified by affinity chromatography on thiol-sepharose was analysed in goats. After challenge, the enriched products induced a slight reduction in the cumulative faecal egg counts (21%) and in the number of worms (23.3%), with a greater effect on female worms, which also showed a reduction in parameters related to their fertility. These parasitological findings were associated with a Th2 immune response, with a prominent local humoral response and an eosinophilic infiltrate in the gastric mucosa (negatively associated with the fertility of female worms and the number of worms, respectively), as well as an infiltration of MCHII+, CD4+, IgG+ and IgA+ cells. However, several analyses showed an increase in CD8+ cells in the mucosa, as well as IL-2 expression in the gastric lymph nodes, which may have been associated with inhibition of protective responses or with the development of mixed Th1/Th2 responses, a finding that should be analysed in future studies. Full article
(This article belongs to the Special Issue Parasitic Infections: Therapy for Host Immunity and Vaccination)
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