Effectiveness and Safety of Vaccines in Special Populations

A special issue of Vaccines (ISSN 2076-393X). This special issue belongs to the section "Vaccine Efficacy and Safety".

Deadline for manuscript submissions: 30 March 2025 | Viewed by 942

Special Issue Editors


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Guest Editor
Department of Adults' Infectious Diseases, Medical University of Warsaw, Warsaw, Poland
Interests: key populations; pregnancy; ageing; immune suppression; vaccination
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Guest Editor
Department of Infectious Disease, Faculty of Medicine, Medical University of Tirana, 1000 Tirana, Albania
Interests: HIV; opportunistic infections; hepatitis; STI; care; mortality

Special Issue Information

Dear Colleagues,

Vaccines are the most effective tool in combating epidemics and reducing disease. We have seen significant advancements in the development of vaccines, especially during the recent SARS-CoV-2 pandemic. However, clinical trials sometimes do not include particular populations such as pregnant women, the elderly, people living with HIV, and those at high risk of infection due to various factors. Additionally, individuals with limited access to healthcare due to geographical or economic barriers are often not included in these trials, and lactating women may also be omitted from clinical studies. We are inviting original submissions of research, viewpoints, and commentaries to this Special Issue which aims to collect recent evidence on the efficacy and safety of different vaccines in specific populations. We look forward to receiving your contributions.

Dr. Justyna Dominika Kowalska
Prof. Dr. Arjan Harxhi
Guest Editors

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Keywords

  • vaccines
  • special populations
  • HIV
  • pregnancy
  • migrants

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Published Papers (1 paper)

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Research

12 pages, 255 KiB  
Article
Potential Association between Shift Work and Serologic Response to Hepatitis B Vaccination among Manufacturing Workers in Republic of Korea
by Si-Ho Kim and Chang-Ho Chae
Vaccines 2024, 12(9), 1041; https://doi.org/10.3390/vaccines12091041 - 11 Sep 2024
Viewed by 718
Abstract
(1) Background: Shift work can affect physical health and the immune system by altering the body’s circadian rhythms. This study investigated the factors associated with the hepatitis B virus (HBV) vaccination response in manufacturing workers, classified by whether they engaged in shift work [...] Read more.
(1) Background: Shift work can affect physical health and the immune system by altering the body’s circadian rhythms. This study investigated the factors associated with the hepatitis B virus (HBV) vaccination response in manufacturing workers, classified by whether they engaged in shift work or not. (2) Methods: This retrospective observational study was conducted among adults employed at two manufacturing companies. Those with negative initial hepatitis B surface antibody (HBsAb) levels before vaccination and who subsequently received a three-dose series of HBV vaccine were enrolled. Hepatitis B surface antibodies were examined for 3 years after the first dose. The endpoint of this study was the failure of a seroprotective anti-HB response after vaccination (HBsAb < 10 mIU/mL). Binary logistic regression models were used to analyze factors associated with response failures. (3) Results: Of the 1103 eligible subjects, 337 (30.6%) were shift workers. The failure rate was numerically higher in the shift workers (9.2%) than in the non-shift workers (7.9%), without statistical significance (p = 0.405). However, after adjustment with the binary logistic regression models, the shift workers had a statistically significantly higher rate of response failures than the non-shift workers (odds ratio 2.87; 95% confidence interval 1.64–5.05, p < 0.001), as did males, older workers, those with a low initial anti-HB titer, those with a vitamin D deficiency, and current smokers. (4) Conclusions: Our findings suggest a possible association between shift work and the serologic responses to HBV vaccination. Novel strategies for vaccination should be considered for shift workers. Full article
(This article belongs to the Special Issue Effectiveness and Safety of Vaccines in Special Populations)
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