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Veterinary Sciences
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Focus on Tumours in Pet Animals
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Focus on Tumours in Pet Animals

A special issue of Veterinary Sciences (ISSN 2306-7381). This special issue belongs to the section "Veterinary Internal Medicine".

Deadline for manuscript submissions: 31 October 2024 | Viewed by 3413

Special Issue Editor

Dr. Louise van der Weyden

E-Mail Website
Guest Editor
Wellcome Sanger Institute, Hinxton, Cambridge CB10 1SA, UK
Interests: oncology; cancer; metastasis; cancer genetics; cancer genomics; comparative oncology; comparative genomics; animal models of cancer
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

As with ourselves, family members or friends, our pets may also develop a tumour during their lifetime. This could be either a benign or malignant tumour, a common or rarely reported tumour type, a tumour type for which prognosis is known or which no prognostic biomarkers are available, and/or a tumour for which therapy is available (either curative or allows for a significant period of disease-free survival) or one in which there are currently no options available (depending on tumour type, stage, and location). The news that our beloved pet has a tumour inevitably makes us want to know everything that there is to know about this tumour type, and sadly, we soon realise that much research remains to be done to be able to provide a better outlook for pets with tumours.

To this end, this Special Issue seeks to showcase investigations into understanding all aspects of neoplasia in pets, from tumourigenesis to progression to development of therapeutic resistance, as well as gaining an understanding of aetiology and thus potential methods of prevention. Some suggested topics include investigations into the underlying genetics or signalling pathways that play a role in driving tumourigenesis and/or tumour progression, identification of diagnostic, prognostic or therapeutic biomarkers, evaluation of current and/or novel treatment regimes, or case reports of novel tumour types/clinical presentations. 

We hope that you will contribute an article to this Special Issue and showcase the dedication and effort that is being put into increasing our understanding of neoplasia in pets.

Dr. Louise van der Weyden
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Veterinary Sciences is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2100 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • dog
  • cat
  • horse
  • rabbit
  • pet
  • neoplasia
  • tumour
  • cancer
  • oncology
  • genetics
  • pathology
  • diagnosis
  • prognosis
  • treatment
  • resistance
  • biomarker
  • presentation

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Published Papers (3 papers)

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Research

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12 pages, 242 KiB  
Article
Multimodal Blockade of the Renin–Angiotensin System in the Treatment of Cancer in Dogs Has Mild Adverse Effects in Some Dogs
by Keren E. Dittmer, Sarah Wetzel, Thomas Odom, John S. Munday, Elizabeth A. Flatt, Ingrid J. Wilson, Catherine Hughes and Swee T. Tan
Vet. Sci. 2024, 11(6), 275; https://doi.org/10.3390/vetsci11060275 - 17 Jun 2024
Viewed by 1664
Abstract
The renin–angiotensin system (RAS) is increasingly being recognized to play a role in the tumor microenvironment, promoting tumor growth. Studies blocking a single part of the RAS have shown mixed results, possibly due to the existence of different bypass pathways and redundancy within [...] Read more.
The renin–angiotensin system (RAS) is increasingly being recognized to play a role in the tumor microenvironment, promoting tumor growth. Studies blocking a single part of the RAS have shown mixed results, possibly due to the existence of different bypass pathways and redundancy within the RAS. As such, multimodal blockade of the RAS has been developed to exert more complete inhibition of the RAS. The aim of the present study was to assess the safety of multimodal RAS blockade in dogs. Five dogs (four with appendicular osteosarcoma, one with oral malignant melanoma) were treated with atenolol, benazepril, curcumin, meloxicam, and metformin. The dogs underwent clinical examination, blood pressure measurement, and hematology and serum biochemistry tests performed at 0, 1, 3, 6, 9, and 12 weeks, then every 3 months thereafter. End-of-life decisions were made by the owners. None of the dogs developed hypotension. One dog had intermittent vomiting during the 64 weeks it was on the trial. One dog had a one-off increase in serum SDMA(symmetrical dimethylarginine) concentration. Dogs were euthanized at weeks 3 (osteosarcoma), 10 (osteosarcoma), 17 (osteosarcoma), and 26 (oral malignant melanoma), and one dog was still alive at the end of the trial at 64 weeks (osteosarcoma). This is the first assessment of multimodal blockade of the RAS in dogs, and the results suggest it causes only mild adverse effects in some animals. The efficacy of the treatment was not assessed due to the small number of dogs. This pilot study allows for future larger studies assessing multimodal RAS blockade for the treatment of canine cancer. Full article
(This article belongs to the Special Issue Focus on Tumours in Pet Animals)

Review

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19 pages, 1292 KiB  
Review
A Review on Canine and Human Soft Tissue Sarcomas: New Insights on Prognosis Factors and Treatment Measures
by Filippo Dell’Anno, Roberta Giugliano, Valeria Listorti and Elisabetta Razzuoli
Vet. Sci. 2024, 11(8), 362; https://doi.org/10.3390/vetsci11080362 - 10 Aug 2024
Viewed by 328
Abstract
Soft tissue sarcomas (STSs) represent a diverse group of tumors arising from mesenchymal cells, affecting both humans and animals, including dogs. Although STSs represent a class of rare tumors, especially in humans, they pose significant clinical challenges due to their potential for local [...] Read more.
Soft tissue sarcomas (STSs) represent a diverse group of tumors arising from mesenchymal cells, affecting both humans and animals, including dogs. Although STSs represent a class of rare tumors, especially in humans, they pose significant clinical challenges due to their potential for local recurrence and distant metastasis. Dogs, as a model for human STSs, offer several advantages, including exposure to similar environmental risk factors, genetic diversity among breeds, and the spontaneous development of tumors. Furthermore, canine tumors closely mimic the heterogeneity and complexity of human tumors, making them valuable for research into disease progression and treatment effectiveness. Current treatment approaches for STSs in both dogs and humans primarily involve surgery, radiation therapy, and chemotherapy, with treatment decisions based on tumor characteristics and patient factors. However, the development of novel therapeutic strategies is essential, given the high failure rate of new drugs in clinical trials. To better design new tailored treatments, comprehension of the tumor microenvironment (TME) is fundamental, since it plays a crucial role in STS initiation and progression by modulating tumor behavior, promoting angiogenesis, and suppressing immune responses. Notably, TME features include cancer-associated fibroblasts (CAFs), extracellular matrix (ECM) alterations, and tumor-associated macrophages (TAMs) that, depending on their polarization state, can affect immune responses and thus the patient’s prognosis. In this review, new therapeutical approaches based on immunotherapy will be deeply explored as potential treatment options for both dogs and humans with STSs. In conclusion, this review provides an overview of the current understanding of STSs in dogs and humans, emphasizing the importance of the TME and potential treatment strategies. Full article
(This article belongs to the Special Issue Focus on Tumours in Pet Animals)
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Other

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8 pages, 27757 KiB  
Case Report
Pulmonary Adenocarcinoma with Cutaneous Metastasis in a Dog
by Anita Greyling, Louise van der Weyden, Antonia V. Lensink and Nicolize O’Dell
Vet. Sci. 2024, 11(7), 312; https://doi.org/10.3390/vetsci11070312 - 11 Jul 2024
Viewed by 926
Abstract
Primary lung cancer is rare in dogs and depending on the tumour stage and subtype, the prognosis can be poor. In this report, we describe a 10 year-old female intact Yorkshire terrier that presented progressive weight loss and chronic pain of unknown origin. [...] Read more.
Primary lung cancer is rare in dogs and depending on the tumour stage and subtype, the prognosis can be poor. In this report, we describe a 10 year-old female intact Yorkshire terrier that presented progressive weight loss and chronic pain of unknown origin. Due to the poor condition of the dog, it was subsequently euthanized. Post-mortem evaluation revealed a single large mass in the left caudal lung lobe, with numerous pale, proliferative lesions of various sizes dispersed throughout all the lobes. Additionally, a solitary skin mass was palpated on the mid-thoracic body wall. Histopathological examination of the lung samples revealed multiple distinct, non-encapsulated, expansive neoplastic epithelial cell proliferations with dense cellularity, exhibiting growth patterns, ranging from papillary to micropapillary to solid, accompanied by central areas of necrosis. In some areas, microvilli-like structures were observed on the luminal cytoplasmic margins of the neoplastic cells. The histopathology of the skin mass closely resembled that of the lung. Electron microscopy of the skin samples revealed regions containing cells resembling the respiratory epithelium, along with cells exhibiting processes or microvilli indicative of cilia. The diagnosis was pulmonary adenocarcinoma with cutaneous metastasis. This is the first report of a canine with primary lung cancer that metastasized to the skin. Full article
(This article belongs to the Special Issue Focus on Tumours in Pet Animals)
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