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Journals
Viruses
Special Issues
Unraveling the Pathogenesis of Persistent Virus Infection
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Unraveling the Pathogenesis of Persistent Virus Infection

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Viral Immunology, Vaccines, and Antivirals".

Deadline for manuscript submissions: 30 November 2024 | Viewed by 519

Special Issue Editors

Prof. Dr. Yasuko Tsunetsugu-Yokota

E-Mail Website1 Website2
Guest Editor
1. Department of Medical Technology, School of Health Sciences, Tokyo University of Technology, Tokyo 144-8535, Japan
2. Research Institute, The World New Prosperity (WNP), Tokyo 169-0075, Japan
Interests: virus infection; immune responses; virus-host interaction; HIV latency; influenza; SARS; coronaviruses
Dr. Mie Kobayashi-Ishihara

E-Mail Website
Guest Editor
Department of Molecular Biology, Keio University School of Medicine, Tokyo 160-8582, Japan
Interests: retroviruses; latency; reactivation; virus-host interactions; HIV; innate immunity

Special Issue Information

Dear Colleague,

Viruses can cause chronic diseases by introducing and maintaining their genetic materials in host cells. Examples include herpesviruses and retroviruses, which employ several tactics to escape from the immune system, allowing them to establish latent/persistent infections. However, the mechanisms underlying the maintenance of these viruses and disease onsets remain largely unclear.

This Special Issue entitled “Unraveling the Pathogenesis of Persistent Virus Infection" aims to present recent research on any aspect of persistent virus infections. Some of its focal points include, but are not limited to, the following:

  1. Understanding the pathophysiology of persistent virus infections;
  2. Advancements in methodologies for studying persistent virus infections in tissues/organs;
  3. Development of novel therapeutics against persistent virus infections;
  4. Perspectives on the pathophysiology of virus-induced chronic diseases.

Reviews, original research, and communications are welcome for submission.

Prof. Dr. Yasuko Tsunetsugu-Yokota
Dr. Mie Kobayashi-Ishihara
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Viruses is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • pathophysiology
  • persistent virus infections
  • chronic diseases
  • latency
  • reactivation

Published Papers (1 paper)

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Review

15 pages, 712 KiB  
Review
Post-Transcriptional HIV-1 Latency: A Promising Target for Therapy?
by Mie Kobayashi-Ishihara and Yasuko Tsunetsugu-Yokota
Viruses 2024, 16(5), 666; https://doi.org/10.3390/v16050666 - 24 Apr 2024
Viewed by 208
Abstract
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple [...] Read more.
Human Immunodeficiency Virus type 1 (HIV-1) latency represents a significant hurdle in finding a cure for HIV-1 infections, despite tireless research efforts. This challenge is partly attributed to the intricate nature of HIV-1 latency, wherein various host and viral factors participate in multiple physiological processes. While substantial progress has been made in discovering therapeutic targets for HIV-1 transcription, targets for the post-transcriptional regulation of HIV-1 infections have received less attention. However, cumulative evidence now suggests the pivotal contribution of post-transcriptional regulation to the viral latency in both in vitro models and infected individuals. In this review, we explore recent insights on post-transcriptional latency in HIV-1 and discuss the potential of its therapeutic targets, illustrating some host factors that restrict HIV-1 at the post-transcriptional level. Full article
(This article belongs to the Special Issue Unraveling the Pathogenesis of Persistent Virus Infection)
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