Viral Accessory Proteins
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "General Virology".
Deadline for manuscript submissions: closed (20 December 2022) | Viewed by 15275
Special Issue Editor
Special Issue Information
Dear Colleagues,
A defining characteristic of complex retroviruses such as human immunodeficiency virus (HIV) and simian immunodeficiency virus (SIV) is the expression of an array of accessory proteins. These accessory proteins typically mediate multiple aspects of adaptive and innate immune evasion and are key viral elements ensuring the virus can thrive in the harsh host environment. Accessory proteins for HIV and SIV include Nef, Vif, Vpr, Vpx, and Vpu. These proteins were originally termed accessory as they can often be dispensable for viral replication in certain in cellulo models. However, these proteins remain critical for the virus replication cycle when expressed within a host and are often critical mediators of viral pathogenesis. Moreover, accessory proteins can often antagonize the specific activity of host restriction factors that are expressed in response to viral infections, rendering the relationship between accessory proteins and restriction factors of particular importance.
In this Special Issue on “Viral Accessory Proteins”, we invite submissions on this exciting topic to highlight recent advances in this field. In addition, in light of the current global pandemic, and the continued study of SARS-CoV-2 open reading frames, we also invite submissions of research papers on SARS-CoV-2 accessory proteins to enhance our understanding of the SARS-CoV-2 genome.
Dr. Jimmy D. Dikeakos
Guest Editor
Manuscript Submission Information
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Keywords
- Nef
- Vpu
- Vpr
- Vif
- SARS-CoV-2
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