Search Results (28)

Background/Objectives: The aim of this study was to evaluate baseline health measurements among transitional housing residents (n = 29) participating in an 8-week pilot wellness intervention. Methods: Researchers measured anthropometrics, body composition, muscular strength, cardiovascular indicators, physical activity, diet quality, and health-related perceptions. Researchers analyzed data using descriptive statistics and conventional content analysis. Results: Most participants were male, White, and food insecure. Mean BMI (31.8 ± 8.6 kg/m²), waist-to-hip ratio (1.0 ± 0.1 males, 0.9 ± 0.1 females), body fat percentage (25.8 ± 6.1% males, 40.5 ± 9.4% females), blood pressure (131.8 ± 17.9/85.2 ± 13.3 mmHg), and daily step counts exceeded recommended levels. Absolute grip strength (77.1 ± 19.4 kg males, 53.0 ± 15.7 kg females) and perceived general health were below reference standards. The Healthy Eating Index-2020 score (39.7/100) indicated low diet quality. Common barriers to healthy eating were financial constraints (29.6%) and limited cooking/storage facilities (29.6%), as well as to exercise, physical impediments (14.8%). Conclusions: Residents living in transitional housing have less favorable body composition, diet, and grip strength measures, putting them at risk for negative health outcomes. Wellness interventions aimed at promoting improved health-related outcomes while addressing common barriers to proper diet and exercise among transitional housing residents are warranted. Full article

Medium-chain fatty acids (MCFAs) refer to a mixture of fatty acids typically composed of 6 to 12 carbon atoms. The unique transport and rapid metabolism of MCFAs provide more clinical benefits than other substrates, such as long-chain fatty acids. Although many studies have shown that MCFAs may improve exercise capacity and muscle strength, applications have mainly been limited to low doses. This study explores the effects of high-dose MCFA intake on muscle strength and exercise endurance. Mice were fed high-fat diets containing 30, 35, and 40% (w/w) MCFAs for 12 weeks, and measurements of grip strength and submaximal endurance exercise capacity were conducted to evaluate muscle function. Results showed that compared to the 30% MCFAs group, the absolute grip strength in the 35 and 40% MCFAs groups significantly increased; in terms of endurance performance, the 35% MCFAs group showed a significant increase compared to the 40% MCFAs group. These results were mainly achieved by promoting muscle regeneration and differentiation and inhibiting the expression of the ubiquitin-proteasome pathway. This study demonstrates that moderately increasing MCFA intake can improve the effects of obesity-induced muscle atrophy. However, excessive intake may reduce the impact of improvement. Full article

One of the physical requirements for marines involves covering a specific distance while carrying individual combat gear, supplies, or other military equipment across challenging terrain. Training for this physically and mentally demanding task is a routine component of their preparation. However, further research is needed to better understand the neuromuscular impact of such demanding efforts, strenuous maneuvers, and the recovery process in the subsequent days. Twenty-nine marines completed a 5 km time trial while carrying 24 kg of combat gear, undergoing evaluations at four time points: pre exercise, immediately post exercise, 24 h post exercise, and 48 h post exercise. Repeated measures ANOVA, paired samples t-test, and effect size (ES) analysis were conducted, presenting the results as the mean ± standard deviation (SD). The significance level was set at p ≤ 0.05. Several variables and their corresponding p-values demonstrated changes over time, including the following: the isometric mid-thigh pull (IMTP) (p = 0.001); countermovement jump height (VJ CMJ) (p ≤ 0.001); rating of fatigue scale (ROF) (p ≤ 0.001); blood lactate (BL) levels (p ≤ 0.001); maximum pull-ups (PUmax) (p ≤ 0.001); body mass (BM) (p ≤ 0.001); dominant hand grip strength (DHGS) (p = 0.406); and non-dominant hand grip strength (NDHGS) (p = 0.805). Incident reports and perceived effort (IRPE) revealed a progressive and significant increase between the first and last kilometer of the test, specifically in perceived variables of fatigue, muscle pain, joint pain, shortness of breath, palpitations, excessive sweating, and muscle tremors (all p ≤ 0.001). These findings may contribute to optimizing training programs to better align with operational demands, thereby improving task performance and overall mission effectiveness. In conclusion, the military test had a significant neuromuscular impact on the body, initially resulting in the potentiation of absolute global isometric strength and lower-limb power. However, these values declined below the baseline levels at 24 and 48 h post test. Full article

Background/Objectives: Muscle weakness in older adults is associated with cardiovascular disease and all-cause mortality. However, its association with stroke prevalence remains underexplored. This study aimed to analyze the absolute grip strength (AGS) and weight-adjusted relative grip strength (RGS) thresholds for stroke prediction in South Korean older adults and to assess their sex-specific predictive ability. Methods: Data from 5185 older adults (2231 men; 2954 women) from the Korea National Health and Nutrition Examination Survey (KNHNES, 2014–2018) were analyzed using complex sampling methods. Receiver operating characteristic (ROC) curve analysis was performed to determine AGS and RGS thresholds and predictive performance, while multivariate logistic regression was used to adjust for confounders and to assess independent effects. Results: In older men, both the AGS and RGS demonstrated significant predictive ability for stroke, with AUCs of 0.637 and 0.623, respectively. In women, the AGS (AUC: 0.608) and RGS (AUC: 0.615) were predictive; however, only the RGS was significant for stroke management (odds ratio (OR): 3.026; 95% confidence interval (CI), 1.541–5.943). In men, AGS (OR: 3.544, 95% CI, 2.094–5.998) and RGS (OR: 2.585, 95% CI, 1.529–4.369) were significant. The stroke prediction thresholds were AGS 28.55 kg and RGS 0.47 for men and RGS 0.36 for women. Conclusions: The AGS and RGS provide practical indicators for stroke risk prediction based on sex-specific differences, highlighting their potential for public health and clinical applications. Future studies should investigate the stroke type, severity, and additional functional fitness indices. Full article

Background/Objectives: Despite widespread use in clinical and athletic settings, validity of handgrip strength (HGS) as a surrogate for maximal strength remains debated, particularly regarding how testing posture influences its predictive value. Moreover, while HGS is frequently considered a marker of ‘total strength’, this term is often vaguely defined, lacking a clear, performance-based framework. Therefore, this study investigates HGS as a potential surrogate measure for one-repetition maximum (1RM) performances in key compound lifts via back squat (BS), bench press (BP), deadlift (DL), and total (TOT), while accounting for variations in testing posture. Methods: Two distinct testing conditions were used to account for postural influences: Experiment 1 implemented high-output standing HGS (HGS_STAND) in 22 recreationally trained males [Wilks Score: 318.51 ± 44.61 au] vs. Experiment 2, which included low-output seated HGS (HGS_SIT) in 22 competitive powerlifters [409.86 ± 46.76 au], with all testing immediately followed by 1RM assessment. Results: Correlational analyses identified the strongest association between HGS_STAND and 1RM DL (r = 0.693, BF₁₀ = 106.42), whereas HGS_SIT exhibited the strongest relationship with 1RM BP (r = 0.732, BF₁₀ = 291.32). Postural effects had a significant impact on HGS outcomes (p < 0.001, η² = 0.413), with HGS_STAND producing higher outputs than HGS_SIT despite lower absolute strength 1RM capabilities. Conclusions: These findings emphasize the role of biomechanical specificity and neuromuscular engagement in grip strength assessments, indicating that HGS can function as a practical surrogate for maximal strength, though its predictive value depends on posture. Strength practitioners, sport scientists, and clinicians should consider these confounding factors when implementing HGS-based monitoring strategies. Full article

Muscular strength and explosiveness are generally known as factors that affect physical performance. Physical ability modeling has a profound connection with long-term athlete development and talent identification. The purpose of the current study was to investigate differences in contractile characteristics (maximal isometric force and maximal rate of force development) among various muscle groups in youth elite female team handball players (n = 35, 16.6 ± 1.1 years) compared to a control group (n = 28, 16.7 ± 1.1 years). The following tests were performed: isometric non-dominant hand grip, isometric dominant hand grip, isometric deadlift, isometric standing leg extension, and isometric bilateral ankle extension. For each subject, the maximal isometric force and maximal rate of force development were derived from the isometric strength tests. The research analyzed a total of twenty-four variables, presented in both absolute and relative values. Statistical analysis revealed significant differences among all pairs of variables in the absolute values of maximal isometric force (Λ = 0.531, F = 10.07, p = 0.000) and maximal rate of force development (Λ = 0.692, F = 5.08, p = 0.001) between the two groups. The most significant difference was found in the grip of the dominant hand, where the impact of the difference was 43.6% and 37.0% for the absolute values of force and explosiveness. Conversely, no differences were observed between the pairs of variables representing the relative values across the two subject groups, except for the dominant hand grip relative force (p = 0.006). The results provide information about the contractile potentials of important muscle groups in the game of handball, which could help in adapting strength training according to the specifics of the strength and explosivity development of young female handball players. Full article

Background: Metabolic syndrome (MS) is a cluster of cardiometabolic risk factors for future diabetes and cardiovascular diseases, and low grip strength (GS) is associated with an increased risk of MS. However, the index (among absolute GS, relative GS, and anthropometric indices) that is more strongly associated with MS has not been conclusively identified. Therefore, the objective of the present study was to simultaneously examine the associations of MS with relative and absolute GS and anthropometric indices in a Korean population. Methods: In this large-scale cross-sectional study, we used data from the Korean National Health and Nutrition Examination Survey (KNHANES). A total of 20,915 subjects were included in the statistical analyses. Complex sample binary logistic regression models were used to analyze the associations between MS and indices such as the waist-to-height ratio (WHtR), body mass index (BMI), and absolute and relative GS. Results: The prevalence of MS was 40.48% in men and 34.4% in women. The mean GS values in the healthy group and MS group were 38.06 ± 0.13 and 38.06 ± 0.15 years for men (p = 0.980) and 22.72 ± 0.07 and 21.19 ± 0.11 years for women (p < 0.001), respectively. Among all the indices, the WHtR was the index most strongly associated with MS in men. Among the GS indices, the GS/weight index was closely associated with MS, and the magnitude of this association was stronger than that of the absolute GS index. In women, the WHtR was the most related index to MS among all the indices. Among the GS indices, the GS/weight and GS/BMI indices were strongly associated with MS, and the magnitudes of these associations were much greater than those of the absolute GS index. Conclusions: Although absolute and relative GS indices are strongly associated with MS in the Korean population, the strongest association was observed for the simple anthropometric index (WHtR). Full article

3-(4-Hydroxy-3-methoxyphenyl)propionic acid (HMPA), also known as dihydroferulic acid, is a hydroxycinnamic acid derivative that can be derived from the microbial transformation of dietary polyphenols or naturally obtained from fermented foods. Although numerous studies have documented its antioxidant and anti-obesity effects, the effect of HMPA on muscle function remains unknown. This study investigated the effects of HMPA on muscle strength and exercise endurance capacity. Mice were orally administered low and high doses of HMPA for 14 days and subjected to grip force and treadmill exhaustion tests to evaluate muscle function. Our results showed that HMPA-administered groups significantly enhanced absolute grip strength (p = 0.0256) and relative grip strength (p = 0.0209), and low-dose HMPA decreased the plasma level of blood urea nitrogen after exercise (p = 0.0183), but HMPA did not affect endurance performance. Low-dose HMPA administration increased Myf5 expression in sedentary mice (p = 0.0106), suggesting that low-dose HMPA may promote muscle development. Additionally, HMPA improved hepatic glucose and lipid metabolism, and inhibited muscular lipid metabolism and protein catabolism, as indicated by changes in mRNA expression levels of related genes. These findings suggest that HMPA may be a promising dietary supplement for muscle health and performance. Full article

(1) Background: The growing prevalence of obesity, diabetes, hypertension, and declining physical fitness among children and adolescents due to sedentary lifestyles has increased attention toward preventive intervention to tackle this issue. This study investigated the age-related effects of high-intensity functional training (HIFT), based on bodyweight resistance exercises conducted during physical education lessons, on muscle mass and strength improvement. (2) Methods: Adolescent males (n = 116) were allocated to four HIFT experimental groups (EGs) and four standard physical education program control groups (CGs) according to age (15, 16, 17, and 18 years [y]). The changes in muscle mass (absolute and relative to height [SMI]), hand–grip strength (HGS), sit-ups (SUs), and standing broad jump (SBJ) were analyzed using two-way analysis of variance (ANOVA) with Bonferroni tests. (3) Results: HIFT significantly increased muscle mass and scores in all strength tests (p < 0.01), while chronological age was significant for HGS (p < 0.01). Interactions between HIFT and chronological age categories were observed for HGS (p = 0.01) and SBJ (p < 0.03). Detailed post hoc tests revealed improvement in muscle mass across all chronological age categories for both approaches (p < 0.05). The 18y-EG group improved HGS over their control peers (p < 0.01), the EG groups significantly improved their SU results (p < 0.01), and SBJ improved in the 15y-EG and 18y-EG groups compared to their control (p < 0.01). (4) Conclusions: This research highlights the effectiveness of a school-based HIFT program in promoting muscle mass gains and enhancing muscle strength among adolescents. The findings offer valuable insights for implementing bodyweight exercises during physical education classes. Full article

Nemaline myopathy is one of the most common non-dystrophic congenital myopathies. Individuals affected by this condition experience muscle weakness and muscle smallness, often requiring supportive measures like wheelchairs or respiratory support. A significant proportion of patients, approximately one-third, exhibit compound heterozygous nebulin mutations, which usually give rise to the typical form of the disease. Currently, there are no approved treatments available for nemaline myopathy. Our research explored the modulation of myostatin, a negative regulator of muscle mass, in combating the muscle smallness associated with the disease. To investigate the effect of myostatin inhibition, we employed a mouse model with compound heterozygous nebulin mutations that mimic the typical form of the disease. The mice were treated with mRK35, a myostatin antibody, through weekly intraperitoneal injections of 10 mg/kg mRK35, commencing at two weeks of age and continuing until the mice reached four months of age. The treatment resulted in an increase in body weight and an approximate 20% muscle weight gain across most skeletal muscles, without affecting the heart. The minimum Feret diameter of type IIA and IIB fibers exhibited an increase in compound heterozygous mice, while only type IIB fibers demonstrated an increase in wild-type mice. In vitro mechanical experiments conducted on intact extensor digitorum longus muscle revealed that mRK35 augmented the physiological cross-sectional area of muscle fibers and enhanced absolute tetanic force in both wild-type and compound heterozygous mice. Furthermore, mRK35 administration improved grip strength in treated mice. Collectively, these findings indicate that inhibiting myostatin can mitigate the muscle deficits in nebulin-based typical nemaline myopathy, potentially serving as a much-needed therapeutic option. Full article

Traumatic finger injuries are very common in emergency medicine. When patients present with finger injuries, there is often damage to the vascular nerve bundles, which requires subsequent reconstruction. It is unknown if repairing a unilaterally injured artery affects patients’ recovery in a well-perfused finger. This retrospective cohort study compares the clinical outcomes of 11 patients with one-vessel supply (mean age 48.3 years; 7 males, 4 females) to 14 patients with two-vessel supply (mean age 44.5 years; 8 males, 6 females). The patient outcomes were assessed using patient questionnaires (Disabilities of Arm, Shoulder, and Hand (DASH), European Quality of Life 5 Dimensions 5 Level Version (EQ-5D-5L), and EuroQol visual analog scale (EQ-VAS)) and a clinical examination of hand function and imaging of circulatory efficiency. No significant changes were observed in the DASH, EQ-5D-5L, and EQ-VAS questionnaires. Clinical evaluation of hand function, measured by cold sensitivity, two-point discrimination, pain numerical analog scale, and grip strength also revealed no significant differences between cohorts. Blood flow measurements using thermal imaging revealed no effects on circulation in the affected digit. Collectively, the study finds reconstruction is not absolutely necessary when there is one intact digital artery as it is sufficient for healing and functional outcomes. We recommend finger artery reconstruction when both digital arteries are injured or if an immediate tension-free suture is possible. Full article

Frailty poses a threat to the daily lives of healthy older adults, highlighting the urgent need for technologies that can monitor and prevent its progression. Our objective is to demonstrate a method for providing long-term daily frailty monitoring using an in-shoe motion sensor (IMS). We undertook two steps to achieve this goal. Firstly, we used our previously established SPM-LOSO-LASSO (SPM: statistical parametric mapping; LOSO: leave-one-subject-out; LASSO: least absolute shrinkage and selection operator) algorithm to construct a lightweight and interpretable hand grip strength (HGS) estimation model for an IMS. This algorithm automatically identified novel and significant gait predictors from foot motion data and selected optimal features to construct the model. We also tested the robustness and effectiveness of the model by recruiting other groups of subjects. Secondly, we designed an analog frailty risk score that combined the performance of the HGS and gait speed with the aid of the distribution of HGS and gait speed of the older Asian population. We then compared the effectiveness of our designed score with the clinical expert-rated score. We discovered new gait predictors for HGS estimation via IMSs and successfully constructed a model with an “excellent” intraclass correlation coefficient and high precision. Moreover, we tested the model on separately recruited subjects, which confirmed the robustness of our model for other older individuals. The designed frailty risk score also had a large effect size correlation with clinical expert-rated scores. In conclusion, IMS technology shows promise for long-term daily frailty monitoring, which can help prevent or manage frailty for older adults. Full article

Firefighters perform strenuous work in dangerous and unpredictable environments requiring optimal physical conditioning. The aim of this study was to investigate the association between physical fitness and cardiovascular health (CVH) in firefighters. This cross-sectional study systematically recruited 309 full-time male and female firefighters between the ages of 20 to 65 years in Cape Town, South Africa. Physical fitness was assessed using absolute (abV̇O_2max) and relative oxygen consumption (relVO_2max), grip and leg strength, push-ups and sit-ups, sit-and-reach for flexibility and lean body mass (LBM). CVH encompassed age, smoking, blood pressure (BP), blood glucose, lipid profile, body mass index, body fat percentage (BF%), and waist circumference. Linear regressions and logistic regressions were applied. Multivariable analysis indicated that relVO_2max was associated with systolic BP (p < 0.001), diastolic BP (p < 0.001), non-fasting blood glucose (p < 0.001), and total cholesterol (p = 0.037). Poor CVH index was negatively associated with relV̇O_2max (p < 0.001), leg strength (p = 0.019), and push-ups (p = 0.012). Furthermore, age was inversely associated with V̇O_2max (p < 0.001), push-up and sit-up capacity (p < 0.001), and sit-and-reach (p < 0.001). BF% was negatively associated with abV̇O_2max (p < 0.001), grip and leg strength (p < 0.001), push-ups (p = 0.008), sit-ups (p < 0.001), and LBM (p < 0.001). Cardiorespiratory fitness, muscular strength, and muscular endurance were significantly associated with a better overall CVH profile. Full article

Older people have higher amounts of sodium accumulation in skeletal muscles than younger people, indicating the possible role of salt intake on muscular and physical function. This large population-based cross-sectional study examined the association of salt intake with muscle strength and physical performance in 4867 participants with an average age of 60.4 (standard deviation = 7.7) years. Information on salt intake was collected from self-reports. Absolute and relative grip strength (AGS and RGS), timed up-and-go test (TUGT), and falls were considered the indicators of muscle strength and physical performance. Linear and logistic regression were used to examine the associations of salt intake with AGS, RGS, TUGT score, and falls, adjusting for demographic and lifestyle factors, body mass index, self-rated health, and self-reported hypertension. Higher salt intake was independently associated with lower grip strength and a higher TUGT score. Versus light salt intake, the adjusted β (95% confidence interval (CI)) of AGS_max, RGS_max, and TUGT scores in those with salty taste were −0.53 (−0.97, −0.08) kg, −0.04 (−0.06, −0.02) kg per kg/m², and 0.08 (0.02, 0.14) s, respectively. A non-significant association was found between salt intake and falls. In sex-stratification analysis, the association remained in women but became non-significant in men. Our results suggest that avoiding high-salt diets may play a role in preserving muscle strength and physical function in the elderly, especially in women. Full article

In this study, we aimed to determine the associations among health-related physical fitness measurements, waist circumference (WC), and abdominal obesity risk in Taiwanese adults. We conducted a cross-sectional study based on data from the 2017 Taiwan Scientific Physical Fitness Survey (the TSPFS). We collected the responses from 17,973 participants (7907 men and 10,066 women) aged 23–64 years for this study. The participants completed the study protocol with a standardized structural questionnaire and a series of health-related physical fitness measurements. The fitness measurements included cardiorespiratory fitness (measured by a 3-min progressive knee-up and step test), muscular fitness (measured by a hand grip strength test), and flexibility (measured by a sit-and-reach test). Our anthropometric measurements included height, weight, WC, hip circumference (HC), body mass index (BMI), and waist-to-hip ratio (WHR). We identified the quartiles of the health-related physical fitness results as the dependent variable in the multiple linear and multiple logistic regression analysis to determine the associations of the physical fitness measurements with WC distribution and abdominal obesity risk. We also considered the dose–response relationship. We found that cardiorespiratory fitness, relative grip strength, and flexibility were each significantly negatively associated with WC, but absolute grip strength was significantly positively associated with WC. We also found that higher levels of cardiorespiratory fitness, relative grip strength, and flexibility were each associated with a lower risk of abdominal obesity. Moreover, our secondary finding was of a dose–response relationship between physical fitness performance, WC, and abdominal obesity risk. In short, health-related physical fitness was an effective predictor of waist circumference for both sexes of Taiwanese adults, and higher levels of health-related physical fitness were associated with lower risks of abdominal obesity in Taiwanese adults. Full article