Search Results (17,404)

Transcranial electrical stimulation, as a means of neural modulation, is increasingly favored by researchers. The distribution and magnitude of the electric field generated within the brain may directly affect the results of neural modulation. Therefore, it is important to clarify the change trend of the cortical electric field and the determinants of the induced electric field in the endodermis at different ages during the adult life cycle. In this study, we used SimNIBS software to perform MR image segmentation and realistic head model reconstruction on 476 individuals (aged 18 to 88 years old) and calculated the cortical electric field of four electrode montages commonly used in cognitive tasks. We divided all participants into groups by age with a span of 10 years for each group and compared the electric field distribution patterns, electric field intensities, and focalities of the cortexes and regions of interest related to cognitive tasks within groups. The degree of influence of global and local anatomical parameters on the electric field was analyzed using a stepwise regression model. The results showed that, in the cortexes and regions of interest, the variability of electric field distribution patterns was highest in adolescents (<20 years old) and elderly individuals (>80 years old). Moreover, throughout the adult lifespan, the electric field induced by transcranial electrical stimulation did not decrease linearly with age but rather presented a U-shaped pattern. In terms of the entire adult life cycle, compared with global anatomical parameters (intracranial brain tissue volume), local anatomical parameters (such as scalp or skull thickness below the electrode) have a greater impact on the amplitude of the intracranial electric field. Our research results indicated that it is necessary to consider the effects caused by different brain tissues when using transcranial electrical stimulation to modulate or treat individuals of different ages. Full article

Background/Objectives: This study aimed to evaluate whether integrating coping strategies into occupational therapy (OT) enhances functional recovery and psychological adaptation after total knee arthroplasty (TKA). Methods: Twenty-eight patients who underwent TKA were equally assigned to an intervention and control group. Both groups received standard goal-oriented OT, while only the intervention group underwent structured training in pain coping strategies using the “Coping List”. Treatment effects were assessed using Canadian Occupational Performance Measure (COPM), pain, anxiety, depression, and pain-related disability scores. Results: A total of 210 coping strategies were identified, with the intervention group adopting an average of 15.1 additional strategies per patient. Strategies were categorized into six domains: physical, psychological and cognitive, social support, relaxation, daily activities, and medication management. The intervention group showed significantly greater improvements in COPM performance scores (7.6 ± 1.7 vs. 5.5 ± 2.6; p = 0.048) and COPM satisfaction scores (7.9 ± 2.0 vs. 5.6 ± 2.8; p = 0.049) compared to the control group. Conclusions: The findings suggest that individualized coping strategies integrated with physical rehabilitation can help patients achieve postoperative goals, enhance recovery, and improve overall well-being. Incorporating such strategies into OT appears to be effective in early-postoperative rehabilitation. Clinical trial number: This study’s clinical trial registration information is available online at UMIN (UMIN000050536). Full article

The “Ten-Year Fishing Ban” policy in the Yangtze River Basin aims to restore ecological diversity but poses significant challenges for the fishermen in their transition to alternative livelihoods. This study focuses on fishermen who worked on Poyang Lake, using the sustainable livelihood framework and the theory of planned behavior, combined with fuzzy-set qualitative comparative analysis (fsQCA) and descriptive statistics, to explore the interaction effects of livelihood capital, ecological cognition, and compensation policies on fishermen’s behavioral responses. Key findings include the following: natural, financial, and psychological capital are core drivers of enhanced ecological cognition, with combined effects significantly increasing sensitivity to policy and environmental changes through pathways like “ecological transition drive”, “knowledge adaptation support”, and “multi-cooperation synergy”. Attitude, perceived behavioral control, and compensation policy transparency are crucial for positive responses, while social norms and policy fairness can compensate for individual motivation deficits, forming pathways like “ecological drive-policy recognition” and “norm drive-social support”. Current issues such as low compensation standards, insufficient retraining, and gender differences limit policy effectiveness. Optimizing measures like differentiated fishing permits, dynamic compensation mechanisms, and cultural empowerment are needed to balance ecological protection and social equity. The study suggests enhancing financial and psychological capital, improving vocational training systems, and increasing policy transparency to provide theoretical and practical references for sustainable global fisheries management. Full article

This study aimed to investigate the impact of cognitive load on moral judgments while incorporating action propensities and collective interests as variables. Study 1 (N = 102) used the dot matrix memory task to manipulate cognitive load, and participants made moral choices in action dilemmas and omission dilemmas. The findings revealed that when confronted with action moral dilemmas, participants in the high-cognitive load group exhibited a greater inclination towards utilitarian responses compared to those in the low-load group. However, cognitive load did not affect utilitarian choices in omission moral dilemmas. Study 2 (N = 100) further introduced the identities of protagonists in dilemmas involving conflicts between collective and individual interests. When facing a collective–individual interest conflict, participants under high cognitive load were more inclined to prioritize collective interests over individual interests compared to those under low load. Additionally, participants were more likely to choose collective interests in omission moral dilemmas than in action dilemmas. The impact of cognitive load on moral judgments was also influenced by the identities of the protagonists. Full article

Canine cognitive dysfunction (CCD) is a neurodegenerative disease likely to affect 14% to 35% of dogs over the age of eight years. Although it can be associated with a high burden of care in owners of affected dogs, there is a lack of knowledge of how veterinarians diagnose and manage the disease. The aim of this study was to determine how veterinary professionals (veterinarians and veterinary nurses/technicians) manage CCD and their attitudes towards the disease using an anonymous online survey. Chi-square tests were used to assess differences according to years of experience, and multiple correspondence analysis was used to analyze clusters according to age, gender, and experience. One hundred and four responses were obtained: 73 veterinarians and 31 veterinary nurses/technicians. Veterinarians diagnosed CCD based on their own experience or by excluding other diseases (27/73, 37% and 25/73, 34%, respectively) and mostly diagnosed a few cases/year (34/73, 47%) or a few in their career (19/73, 26%). CCD was managed using specific medication or environmental changes (57/73, 78% and 58/73, 79%, respectively). Over half of veterinarians agreed/strongly agreed that they were confident in diagnosing CCD (49/73, 67%) and in giving advice on symptom management (53/73, 71%), but only 14/31 (45%) of veterinary nurses/technicians agreed that veterinarians in their practice actively treated dogs with CCD. Participants mostly agreed that CCD is associated with a large burden of care for owners, but less than half measured this burden of care. Although veterinary professionals are aware of CCD, the low rate of diagnosis suggests many dogs are undiagnosed. Increased awareness of the disease by the veterinary profession will enhance human and dog welfare. Full article

The purpose of this study is to investigate the effects of verbal working memory (VWM) interventions on reading speed, accuracy, and comprehension in elementary school students diagnosed with specific learning disabilities (SLD). Given the limited research on the role of VWM in reading performance, this study fills a critical gap in the literature. A pre-test and post-test design was employed, with an experimental group (n = 14) receiving VWM interventions over 4 weeks, while the control group (n = 12) received no intervention. The intervention focused on enhancing VWM and verbal short-term memory (V-STM) through structured cognitive tasks, including rehearsal techniques and phonological loop strengthening activities, delivered over 24 sessions. Results showed that although VWM interventions significantly enhanced VWM capacity (t(24) = 3.39, p < 0.05, d = 1.48), they did not lead to significant improvements in reading speed or accuracy. However, a statistically significant improvement in reading comprehension was observed (p = 0.04, d = 0.92). These findings suggest that while enhancing VWM may not directly improve reading fluency, it can positively affect comprehension. The study highlights the importance of considering VWM in educational interventions targeting reading comprehension and recommends further research into other cognitive and linguistic factors influencing reading speed and accuracy. Additionally, future studies should explore the long-term effects of diverse intervention strategies on reading outcomes. Full article

Background: Carotenoids are bioactive tetraterpenoid C40 pigments that are actively synthesized by plants, bacteria, and fungi. Compounds such as α-carotene, β-carotene, lycopene, lutein, astaxanthin, β-cryptoxanthin, fucoxanthin, and zeaxanthin have attracted increasing attention for their antiaging properties. They exhibit antioxidant, neuroprotective, and anti-inflammatory properties, contributing to the prevention and treatment of age-related diseases. Objectives: The aim of this study was to comprehensively analyze the pharmacological potential and biological mechanisms of carotenoids associated with age-related disorders and to evaluate their application in nutraceuticals, pharmaceuticals, and cosmeceuticals. Methods: A systematic review of studies published over the past two decades was conducted using the databases PubMed, Scopus, and Web of Science. The selection criteria included clinical, in silico, in vivo, and in vitro studies investigating the pharmacological and therapeutic effects of carotenoids. Results: Carotenoids demonstrate a variety of health benefits, including the prevention of age-related macular degeneration, cancer, cognitive decline, metabolic disorders, and skin aging. Their role in nutraceuticals is well supported by their ability to modulate oxidative stress and inflammatory pathways. In pharmaceuticals, carotenoids show promising results in formulations targeting neurodegenerative diseases and metabolic disorders. In cosmeceuticals, they improve skin health by protecting it against UV radiation and oxidative damage. However, bioavailability, optimal dosages, toxicity, and interactions with other bioactive compounds remain critical factors to maximize therapeutic efficacy and still require careful evaluation by scientists. Conclusions: Carotenoids are promising bioactive compounds for antiaging interventions with potential applications in a variety of fields. Further research is needed to optimize their formulas, improve bioavailability, and confirm their long-term safety and effectiveness, especially in the aging population. Full article

The regularity of sleep–wake cycles is a defining characteristic of normative sleep patterns that are typically associated with proper circadian rhythmicity. The previous literature indicates that consistent patterns of sleep and wake are associated with improved sleep quality and cognitive functioning. Conversely, sleep irregularity has been associated with reduced well-being and inefficiency in resting-state neural networks. This study investigated the relationship between specific sleep regularity measures and outcomes, including emotional affect, sleep quality, and resting-state functional connectivity. We found that variability in wake onset predicted poorer sleep quality and reduced positive affect. Furthermore, sleep regularity measures were associated with altered functional connectivity between the posterior cingulate cortex and regions involved in emotional processing. We propose that alterations in default mode network (DMN) connectivity linked to sleep irregularity reflect disruptions in emotional processing and sleep quality. Full article

Objectives: The main objective of this cross-sectional study was to investigate if there are significant differences in cognition between a group of older adults with subjective cognitive decline (SCD) and cognitively intact controls. Methods: An initial sample of 132 older people underwent an extensive neuropsychological evaluation (memory, executive functions, and language) and were classified according to diagnostic criteria. Two groups of 33 subjects each, controls and SCD, were formed using an a priori case-matching procedures in different variables: age, biological sex, years of education, cognitive reserve, and Mini-Mental State Exam. Results: The mean age and standard deviation in the control group were equal to 70.39 ± 4.31 years, while in the SCD group, they were 70.30 ± 4.33 years. The number of males (n = 9) and females (n = 24) was equal in both groups; the means of years of education were also quite similar. SCD participants have a significantly lower mood than the controls. Significant differences between groups were obtained in delayed recall, inhibitory control, and comprehension of sentences not fitted to canonical word order in Spanish. A logistic regression revealed that a lower score on the Stroop’s interference condition is associated with a higher likelihood of having SCD. Finally, ROC analysis provided a model that performs better than random chance, and a cut-off score in Stroop’s interference condition equal to 49 was suggested for clinically differentiating the two groups. Conclusions: This study highlights that, compared to a matched control group, participants with SCD showed subtle but significant neuropsychological differences. Full article

Background/Objectives: Phenylketonuria (PKU) is a rare inherited metabolic disorder caused by phenylalanine hydroxylase deficiency, resulting in highly elevated blood phenylalanine (Phe) concentrations, leading to neurotoxic effects. Despite advancements in treatment, adult patients with PKU may experience impairments in executive functions (EFs). This study investigates the influence of metabolic control across different life stages on EFs and sociodemographic outcomes in adult PKU. Methods: We conducted a monocentric study with 36 early-diagnosed and treated PKU patients (mean age: 34.8 years). EFs were assessed using the Test Battery for Attentional Performance (TAP) and the Tower of London (TL-D). Metabolic data were extracted from medical records, focusing on childhood and adulthood metabolic control, including Phe fluctuations. Sociodemographic data were collected via questionnaires. Statistical analyses explored relationships between EFs, metabolic control, and sociodemographic data. Results: EFs in the cohort were within the lower average range. Significant negative correlations could be observed between EF performance and dried blood Phe concentrations during childhood (ages 0–10 years) as well as current Phe concentrations and Phe variation. Elevated childhood Phe concentrations were associated with lower educational attainment. Sociodemographic characteristics, such as employment status and living arrangements, aligned with those of the general population. Conclusions: Optimal cognitive development in PKU requires good metabolic control, particularly in early childhood. In adulthood, while dietary restrictions may be relaxed, maintaining low and stable Phe concentrations is crucial for EFs. Consistent monitoring and tailored therapeutic approaches throughout life seem essential for optimizing metabolic and neurocognitive outcome in PKU. Full article

The Artemis missions will establish a sustainable human presence on the Moon, serving as a crucial steppingstone for future Mars exploration. Astronauts on these ambitious missions will have to successfully complete complex tasks, which will frequently involve rapid and effective decision making under unfamiliar or high-pressure conditions. Exposure to low doses of space radiation (SR) can impair key executive functions critical to decision making. This study examined the effects of exposure to 10 cGy of Galactic Cosmic Ray simulated radiation (GCRsim) on decision-making performance in male and female rats with a naturally low predisposition for risk-taking (RTP) prior to exposure. Rats were assessed at monthly intervals following SR exposure and the RTP performance contrasted with that observed during the prescreening process. Exposure to 10 cGy of GCRsim impaired decision making in both male and female rats, with sex-dependent outcomes. By 30 days after SR exposure, female rats became more risk-prone, making less profitable decisions, while male rats retained their decision-making strategies but took significantly longer to make selections. However, continued practice in the RTP tasks appeared to reduce/reverse these performance deficits. This study has expanded our understanding of the range of cognitive processes impacted by SR to include decision making. Full article

Background: The harmonious development of gross motor skills (GMSs) is vital for children, fostering their physical, cognitive, and socio-emotional growth. This study aimed to achieve three primary objectives: (1) to establish standardized reference values for all GMS tests conducted; (2) to examine the impact of overweight and obesity on factors influencing the development of GMSs and cardiorespiratory fitness (CRF); and (3) to investigate the relationship between GMSs and CRF levels and body image dissatisfaction among Canadian children from the province of Québec. Methods: The study encompassed 3144 children aged 6 to 12 years (1535 boys and 1609 girls) recruited from 24 elementary schools situated in five urban areas. Anthropometric measurements included body mass, body height, and body mass index (BMI). Physical performance was assessed using a maximal aerobic power test and 12 GMS tests, which comprised two segmental speed tests, four agility tests, two static balance tests, one simple reaction time test, and three coordination tests. Body perception and body image dissatisfaction were evaluated using a silhouette scale featuring two sets of nine drawings depicting a spectrum of body shapes ranging from very thin to obese. Results: Standardized normative values were established for each GMS test. GMSs demonstrated continuous improvement throughout childhood, albeit with a deceleration in progress during later developmental stages. At comparable age, boys generally outperformed girls on tests demanding greater strength, speed, or endurance, whereas girls exhibited superior performance in balance and hand–foot coordination tasks (p ≤ 0.05). However, segmental speed remained equivalent between sexes (p > 0.05). GMS and CRF were significantly influenced by obesity status. Children with a normal BMI demonstrated superior performance compared to their overweight or obese counterparts, particularly in tests requiring body mass displacement (p ≤ 0.05). Conversely, socioeconomic status exhibited no significant impact on body perception in boys (p = 0.106), but it was a notable factor among 6–8-year-old girls from lower socioeconomic backgrounds (p = 0.045). Conclusions: Obesity status is linked to diminished GMS performance, especially in tasks involving body mass movement. These findings underscore the importance of early intervention strategies to encourage an active lifestyle and promote a healthy body composition in children. Full article

Psychiatric disorders (PDs), including schizophrenia (SZ), major depressive disorder (MDD), bipolar disorder (BD), autism spectrum disorder (ASD), among other disorders, represent a significant global health burden. Despite advancements in understanding their biological mechanisms, there is still no reliable objective and reliable biomarker; therefore, diagnosis remains largely reliant on subjective clinical assessments. Peripheral biomarkers in plasma or serum are interesting due to their accessibility, low cost, and potential to reflect central nervous system processes. Among these, the insulin-like growth factor (IGF) family, IGF-1, IGF-2, and IGF-binding proteins (IGFBPs), has gained attention for its roles in neuroplasticity, cognition, and neuroprotection, as well as for their capability to cross the blood–brain barrier. This review evaluates the evidence for IGF family alterations in PDs, with special focus on SZ, MDD, and BD, while also addressing other PDs covering almost 40 years of history. In SZ patients, IGF-1 alterations have been linked to metabolic dysregulation, treatment response, and hypothalamic–pituitary–adrenal axis dysfunction. In MDD patients, IGF-1 appears to compensate for impaired neurogenesis, although findings are inconsistent. Emerging studies on IGF-2 and IGFBPs suggest potential roles across PDs. While promising, heterogeneity among studies and methodological limitations highlights the need for further research to validate IGFs as reliable psychiatric biomarkers. Full article

Background: The Zika virus (ZIKV) is an arbovirus linked to “Congenital Zika Syndrome” and a range of neurodevelopmental disorders (NDDs), with microcephaly as the most severe manifestation. Milder NDDs, such as autism spectrum disorders and delays in neuropsychomotor and language development, often go unnoticed in neonates, resulting in long-term social and academic difficulties. Murine models of ZIKV infection can be used to mimic part of the spectrum of motor and cognitive deficits observed in humans. These can be evaluated through behavioral tests, enabling comparison with gene expression profiles and aiding in the characterization of ZIKV-induced NDDs. Objectives: This study aimed to identify genes associated with behavioral changes following a subtle ZIKV infection in juvenile BALB/c mice. Methods: Neonatal mice were subcutaneously inoculated with ZIKV (MH544701.2) on postnatal day 1 (DPN) at a dose of 6.8 × 10³ PFU. Viral presence in the cerebellum and cortex was quantified at 10- and 30-days post-infection (DPI) using RT-qPCR. Neurobehavioral deficits were assessed at 30 DPI through T-maze, rotarod, and open field tests. Next-Generation Sequencing (NGS) was performed to identify differentially expressed genes (DEGs), which were analyzed through Gene Ontology (GO) and KEGG enrichment. Gene interaction networks were then constructed to explore gene interactions in the most enriched biological categories. Results: A ZIKV infection model was successfully established, enabling brain infection while allowing survival beyond 30 DPI. The infection induced mild cognitive behavioral changes, though motor and motivational functions remained unaffected. These cognitive changes were linked to the functional repression of synaptic vesicles and alterations in neuronal structure, suggesting potential disruptions in neuronal plasticity. Conclusions: Moderate ZIKV infection with circulating strains from the 2016 epidemic may cause dysregulation of genes related to immune response, alterations in cytoskeletal organization, and modifications in cellular transport mediated by vesicles. Despite viral control, neurocognitive effects persisted, including memory deficits and anxiety-like behaviors, highlighting the long-term neurological consequences of ZIKV infection in models that show no apparent malformations. Full article

Physical fitness is defined as the ability to perform daily activities efficiently and without excessive fatigue, involving anthropometric variables and physical capacities. This study evaluates the effects of an adapted physical exercise program in older adults with and without severe cognitive impairment (SCI), aiming to compare its effects on blood pressure, anthropometric parameters, and physical fitness. The study included 78 older adults (24 with SCI) who participated in an individualized exercise program for one year, attending at least twice a week. Variables such as body mass index (BMI), body fat percentage (%BF), handgrip strength (HGS), aerobic endurance (6MiWa), balance, coordination, and agility were assessed. The results show significant improvements (p < 0.05) in most variables after the intervention, especially in flexibility, walking speed, and coordination. Although adults with SCI started with lower baseline levels, the magnitude of the improvements was similar to that of adults without SCI. However, greater deterioration was observed in handgrip strength and lower limb strength in adults with SCI, highlighting the need for specific interventions for this population. The study concludes that adapted physical exercise improves physical fitness and anthropometric parameters in older adults with and without SCI. It emphasizes the importance of using playful and communicative strategies to ensure the active participation of adults with SCI, promoting their functionality and physical independence. Full article