Search Results (73)

The giant moray eel (GME; Gymnothorax javanicus) is an important marine species that plays a key ecological role in reef systems and is a valued food source for indigenous communities. However, it is well-known that GMEs pose a food safety risk due to their ability to accumulate high levels of ciguatoxins (CTXs), the toxins known to cause ciguatera poisoning. This study assessed the age, CTX levels, elemental composition, and nutritional profile of seven GME specimens collected from Muri Lagoon, Rarotonga (Cook Islands), representing the most detailed compositional investigation on this species. Age was determined for the three largest specimens, with the oldest being 39 years old. All specimens contained ciguatoxins, with Type I (CTX4A derivatives), Type II (CTX3C derivatives), algal-ciguatoxins, and biotransformed metabolites being detected. There was a higher CTX content in the liver samples compared to flesh samples, with the longest–heaviest specimen containing the highest levels. The CTX1B level observed in flesh samples of all seven eel specimens exceeded the recommended safe guidance level proposed by the USFDA. A similar ciguatoxin profile was observed across flesh sections, with the belly flap or top loin containing the highest levels of CTXs in most specimens. No bioactive metabolites produced by co-occurring harmful microalgae, including regulated shellfish toxins, were detected. Elemental analysis determined the presence of 21 elements, including arsenic, low levels of mercury, and the volcanic elements rubidium and strontium. Nutritionally, the GMEs were shown to be a lean protein source; however, due to the ubiquitous bioaccumulation of CTXs, they pose a food safety risk to consumers. Full article

The aim of this scoping review was to identify the attributes that have led female leaders and coaches to be successful in high-performance (HP) sport and uncover what may be missing elements aiding women wishing to advance in HP sport. To date, most research has focused on addressing the shortage of women in sports from the organizational perspective. This study investigates the challenges, and coping skills women have encountered on an individual level. Drawing attention to the skills and experiences of women who have been successful in attaining and maintaining their role in HP sport has the potential to help others advance in the field. Abstract screening (n = 411) and full-text reviews (n = 25) resulted in the inclusion of 16 studies. Included studies were conducted in the UK, Canada, Australia, the USA, and Europe, giving this review broad worldwide scope. Several areas of interest were revealed during data analysis: the challenges these women face working in the male dominated world of sport, how they faced and overcame those challenges and have maintained their role in HP sport, and the connectivity that has been established as a support mechanism for women in a leadership role. Lastly, these women discussed competency and knowledge of the sport as an important aspect of their tenure. What is absent from the literature, and exemplified in these data, is a clearly defined pathway into HP sport for the competent and knowledgeable female leader. The specific steps she can take are yet to be defined. Full article

Background/Objectives: Hepatocellular carcinoma (HCC) is the predominant form of liver cancer and currently is the second-leading cause of cancer-related mortality globally. Current front-line systemic therapies for advanced HCC offer only modest improvements in patient overall survival. HCC is a sexually dimorphic disease, and cancer progression is driven in part by AR activity. Here, we present novel niclosamide pro-drugs for use in advanced HCC based upon niclosamide’s known anti-AR activity and additional anti-cancer pathway efficacy. Methods: Niclosamide analogs were evaluated for their impacts on the AR protein in two HCC cell lines with different AR phenotypes. Amino acid conjugates of niclosamide were developed, and pharmacokinetic (PK) analyses were conducted to determine improvements in clearance and oral exposure. Finally, niclosamide analogs and amino acid conjugates were evaluated in an in vivo model of HCC. Results: Niclosamide analogs maintained anti-AR properties in HCC. Valine-conjugated niclosamide showed improved oral exposure, positioning it as a potential therapeutic in advanced HCC. Conclusions: Valine–niclosamide improves upon niclosamide’s poor solubility and oral bioavailability, increasing its utility for a variety of therapeutic uses. Further study of valine–niclosamide in advanced HCC and in other cancers or diseases is warranted. Full article

The use of hearing technology is one of the most effective strategies for providing access to spoken language and the auditory environment for students who are deaf or hard of hearing. In recent years, rapid advancements in hearing technologies have significantly improved access to spoken languages for learners of all ages. As part of the Special Issue “Educating Deaf Students in the 21st Century: A Changed and Changing Context”, this article describes how changes in hearing technology are related to changes in where and how students who are deaf or hard of hearing are educated. This article is designed to provide a foundation of knowledge about today’s hearing technologies for families, educators, and professionals such as speech–language pathologists or early childhood educators who support families and students. It provides an overview of hearing technology options, how they are prescribed and fit, and how benefits for language and literacy development can be evaluated. Barriers to effective use and future directions for hearing technologies are also described. The section “Highlights for Educators and Families” in the article discusses the practical application of this information to the work of those supporting students who are deaf or hard of hearing at home, at school, and in the community. Full article

Traditional proportional–integral–derivative (PID) controllers are often utilized in industrial control applications due to their simplicity and ease of implementation. This study presents a novel control strategy that integrates the Groupers and Moray Eels Optimization (GMEO) algorithm with a Dual-Stream Multi-Dependency Graph Neural Network (DMGNN) to optimize PID controller parameters. The approach addresses key challenges such as system nonlinearity, dynamic adaptation to fluctuating conditions, and maintaining robust performance. In the proposed framework, the GMEO technique is employed to optimize the PID gain values, while the DMGNN model forecasts system behavior and enables localized adjustments to the PID parameters based on feedback. This dynamic tuning mechanism enables the controller to adapt effectively to changes in input voltage and load variations, thereby enhancing system accuracy, responsiveness, and overall performance. The proposed strategy is assessed and contrasted with existing strategies on the MATLAB platform. The proposed system achieves a significantly reduced settling time of 100 ms, ensuring rapid response and stability under varying load conditions. Additionally, it minimizes overshoot to 1.5% and reduces the steady-state error to just 0.005 V, demonstrating superior accuracy and efficiency compared to existing methods. These improvements demonstrate the system’s ability to deliver optimal performance while effectively adapting to dynamic environments, showcasing its superiority over existing techniques. Full article

This paper proposes a collision avoidance method for vehicle longitudinal velocity control based on multi-vehicle collision distance estimation. The method begins by estimating the position and shape of object vehicles with collision risk using environmental sensors. The collision point is identified from the object vehicle’s surface, and a Kalman filter is applied for accurate estimation. The optimal collision distance is then determined by evaluating the collision risk at the identified point. A longitudinal control technique, incorporating the optimal collision distance and time gap, is employed to implement the collision avoidance system. The proposed method was validated through scenario-based simulations involving multi-vehicle collision avoidance, which were implemented in an environment combining ROS and the MORAI simulator, along with comparative experiments. Comparative studies with conventional vehicle center-based approaches demonstrated that the proposed surface-based collision point method significantly enhances collision avoidance performance. While the conventional method led to a collision between the ego and object vehicles, the proposed method successfully avoided the collision by maintaining a separation of about 3.6 m, demonstrating its feasibility and reliability. Full article

On 5 November 2020, a poisoning event involving four people by the consumption of moray eel occurred in Khanh Hoa Province, Viet Nam, with signs indicative of ciguatera. The remaining moray portion was confiscated for identification of causative species and responsible toxins. The phylogenetic study based on COX1 identified the moray as Gymnothorax javanicus Bleeker (1859). Out of 17 marine lipophilic toxins (MLPs) that were analyzed using LC-MS/MS, only Pacific ciguatoxin-1 (P-CTX-1) was detected in the moray’s flesh at 1.30 ± 0.004 ng/g ww, while no toxin was found in the skin. The N2a assay’s ciguatoxicities in the skin and flesh were 0.69 ± 0.075 and 2.49 ± 0.216 ng P-CTX-1/g ww equivalent, respectively. In the N2a assay, the P-CTX-1 amount in the moray flesh was 1.9 times greater than that determined by LC-MS/MS, indicating the presence of additional sodium channel activators or a matrix effect. The P-CTX-1 amount in the moray flesh was at a level that generates major ciguatera poisoning (CP) symptoms in humans (1.0 ng/g P-CTX-1), makes sense given that four consumers experienced the onset of poisoning symptoms. This study is significant for the management of seafood safety since it is the first scientific report on the species and toxin in a moray causing ciguatera in Viet Nam. Full article

Despite growing evidence on the influence of neighborhood characteristics on maternal well-being, there is a critical gap in the availability of validated instruments for measuring these constructs across different cultural settings. Existing neighborhood-related scales often lack cross-cultural validation, limiting their applicability in low- and middle-income countries. Understanding the impact of neighborhood characteristics is crucial given its multigenerational impact. We used data from the Evidence for Better Lives dataset to assess the conceptual and measurement equivalence of the community scales of neighborhood cohesion, intergenerational closure, and neighborhood and social disorder, testing for measurement invariance across eight low- and middle-income countries. Secondly, we examined patterns of associations with prenatal maternal stress, well-being, and depressive symptoms through the use of nomological networks. We found that the conceptual and measurement equivalence of the neighborhood domains were comparable across the eight studied countries. Additionally, our results suggest that higher levels of neighborhood and social disorder and lower levels of cohesion and intergenerational closure in the community are associated with adverse maternal outcomes across the included sites. The results of this study stress the importance of exploring the community context when assessing maternal well-being and supports the need to advocate for community-based interventions that promote safer physical and social environments within maternal programs and urban planning. Full article

Teacher agency has been recognised as a relevant concept for understanding the role of teachers in the current uncertain and changing contexts. However, its study about inclusive education is recent, especially in the Global South. This study analysed how teachers exercised agency for inclusive education during the COVID-19 crisis and the conditions that enabled or inhibited agency. This article explores Chilean schools, where neoliberal policies particularly challenge teachers’ agency. A multiple case study was conducted based on mixed methods. Online questionnaires were carried out with 154 teachers from 5 schools. In addition, five teachers from each school participated in in-depth group interviews. The findings show how teachers promoted students’ learning and participation in response to the challenges of the pandemic. Teachers mobilised resources to adapt to the context of uncertainty and supported one another. Among the influential factors, education policy constraints and control were reduced during the pandemic, thus creating opportunities to achieve agency for inclusion across the schools. At the same time, leadership, collaboration, and vision influenced agency differently in each school. While not aiming for major transformations, this study shows how teachers develop initiatives to adapt their practices and contribute to building inclusive schools despite contextual constraints. Full article

A cognitive apprenticeship (CA) approach to the development of professional judgement and decision making has been examined in a variety of professional contexts in recent years. More recently several authors have theorised that CA may be an effective approach to developing judgement and decision making in outdoor professionals. This paper reports on a unique study of an in-house national coach development programme in the Outward Bound Trust (the Trust) in the UK. It examines the extent to which a CA framework is currently utilised in the development of coaches and considers how the current approach to coach development may be enhanced. This embedded mixed methods study proceeded in two parts: firstly a mixed online survey for the coaches, followed by a participatory focus group of the ‘in house’ coach trainers. The results found that aspects of the CA approach are used to varying degrees, depending on the experience and knowledge of the coach trainers, although limitations with the application of the CA approach are compensated by the organisation’s educational culture and through an established community of practice. Additionally, the application is inconsistent across the organisation. The findings highlight the need for increased intentionality, alignment with organisational values, and Trust-wide development of coach trainers in order to expand the existing approach and align it with the application of a CA within the Trust. Full article

Student-teacher relationships matter in creating inclusive student engagement opportunities in higher education. Student engagement is a wide-ranging topic, and much of the existing literature discusses student course representation (where student leaders gather feedback and work with staff to enhance the quality of courses) and curriculum co-creation (where students and teachers partner in decision-making regarding aspects of a course) as two distinct approaches. However, there is a notable paucity of prior empirical research comparing the ways that student representation and curriculum co-creation can lead to different forms of relationship-building. Therefore, this qualitative study first examined student course representatives’ and co-creators’ perceptions of effective student-teacher relationships in courses, followed by an analysis of the differences in those relationships between teachers and (a) course representatives and (b) curriculum co-creators. We identified five elements of effective student-teacher relationships within the classroom context that help students feel included, connected, respected, valued, and inspired. We found that different communication structures inherent in course representation and curriculum co-creation yielded distinct contributions and risks in building inclusive student-teacher relationships. To deepen understanding of inclusive student engagement, we explore opportunities to enhance these relationships and work towards meaningful partnerships between students and teachers that can advance social justice. Full article

Background/Objectives: Advancements in breast cancer therapeutics, such as anthracyclines, are improving cancer survival rates but can have side effects that limit their use. Cardiotoxicity, defined as damage to the heart caused by cancer therapeutics, is characterised by a significant reduction in left ventricular ejection fraction (LVEF) and symptoms of cardiac dysfunction. Multiple oral supplements exist with antioxidant and anti-inflammatory properties that have the potential to lower cardiotoxicity risk and ameliorate the complications associated with left ventricular dysfunction. In this review, we evaluate the current status of using nutritional interventions to modulate cardiotoxicity. Methods: We used specific keywords to search for articles that met our predetermined inclusion and exclusion criteria to review the evidence and provide insights for future research. Results: Seven studies were identified as eligible for this review: six focused on oral supplementation strategies in breast cancer patients undergoing chemotherapy, and one focused on nutritional counselling and adherence to the Mediterranean diet in breast cancer survivors’ post-treatment. There was a significantly attenuated reduction in LVEF in five studies that monitored cardiometabolic health, and there were significant improvements in blood serum levels of cardiac biomarkers across all studies. Conclusions: Current evidence suggests that appropriate nutritional interventions, alongside chemotherapy, can modulate the risk of cardiotoxic side effects. This highlights the potential of oral antioxidant supplementation and Mediterranean diet counselling to decrease tertiary cancer therapy costs associated with cardiovascular complications. Full article

This study aimed to examine the relationship between family variables (i.e., family support, family SES, parental career-related behavior (PCB) support, PCB interference, and a PCB lack of engagement) and career adaptability through a meta-analysis. A systematic search for relevant studies was conducted using research databases. Twenty-four quantitative studies were yielded from 1684 records on the association between family variables and CA that were published between 1981 and 2024. Two researchers conducted data extraction independently, following coding standards. Comprehensive Meta-Analysis Version 3.3 was used in this study. The result showed that PCB support demonstrated a moderately significant correlation with CA and the largest effect size (r = 0.325). A non-significant result was found only for the correlation between PCB interference and CA. Except for gender, the moderating effects of region, age, CA measure, and publication year were found in the relationship between some family variables and CA. One limitation is the restricted range of the samples due to few studies investigating samples from regions other than Asia. The findings can highlight future directions for family studies and career research and hold practical implications for institutes, companies, and communities related to career development. This study was registered in the Open Science Framework (10.17605/OSF.IO/76HNQ). Full article

This study introduces an innovative Teleoperated Driving (ToD) system integrated with virtual twin technology using the MORAI simulator. The system minimizes the need for extensive video data transmission by utilizing text-based vehicle information, significantly reducing the communication load. Key technical advancements include the use of high-precision GNSS devices for accurate vehicle location tracking, robust data communication via the MQTT protocol, and the implementation of the Ego Ghost mode in the MORAI simulator for precise vehicle simulation. The integration of these technologies enables efficient data transmission and enhanced system reliability, effectively mitigating issues such as communication blackouts and delays. Our findings demonstrate that this approach ensures stable and efficient operation, optimizing communication resource management and enhancing operational stability, which is crucial for scenarios requiring high video quality and real-time response. This research represents a significant advancement in ToD technology, establishing a precedent for integrating virtual twin systems to create more resource-efficient and reliable autonomous driving backup solutions. The virtual twin-based ToD system provides a robust platform for remote vehicle operation, ensuring safety and reliability in various driving conditions. Full article

Ciguatera is a foodborne disease caused by ciguatoxins (CTXs), produced by dinoflagellates (genera Gambierdiscus and Fukuyoa), which bioaccumulate in fish through the food web, causing poisoning in humans. Currently, the physiological mechanisms of the species with the highest amount of toxins in their adult stage of life that are capable of causing these poisonings are poorly understood. Dusky grouper (Epinephelus marginatus) is a relevant fishing species and is part of the CTX food chain in the Canary Islands. This study developed an experimental model of dietary exposure featuring adult dusky groupers with two diets of tissue naturally contaminated with CTXs (amberjack and moray eel flesh) with two different potential toxicities; both groups were studied at different stages of exposure (4, 6, 10, 12, and 18 weeks). The results showed that this species did not show changes in its behavior due to the provided feeding, but the changes were recorded in biochemical parameters (mainly lipid and hepatic metabolism) that may respond to liver damage and alterations in the homeostasis of the fish; more research is needed to understand histopathological and cytotoxic changes. Full article