Search Results (45)

This work presents an ultra-low-power on-chip energy management (EM) circuit, which is the most critical and power-intensive block in power management integrated circuits (PMICs) used for energy harvesting (EH) applications. Ultra-low power consumption was the primary design priority to ensure suitability for systems operating under strict energy limitations. The design relies on a compact latch-based core and avoids the need for extra circuits such as voltage references, comparators, or logic blocks, which helps reduce both area and power. To implement the required high resistance, a series of diode-connected zero-threshold NMOS transistors is used. This approach enables very high resistance in a compact area without additional power consumption or biasing issues at low voltages. A PMOS transistor is also integrated at the EM output to directly control different types of loads. The circuit was designed and fabricated using a 65 nm CMOS standard process. Experimental measurements from the fabricated chips show a quiescent current of 170 nA at 3 V and a voltage hysteresis of over 0.9 V. In addition, temperature and process variation were simulated to verify robust operation. These results confirm that the circuit operates reliably under ultra-low-power conditions and is well-suited for EH systems. Full article

Magnesium alloy represents a typical category of biodegradable medical materials. However, the poor corrosion resistance and rapid degradation have significantly hindered the clinical adoption of magnesium alloy implants. This paper puts forward a method to improve the corrosion resistance of magnesium alloy by using an Fe-based composite coating. The microstructure and composition of the coating were analyzed by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and energy-dispersive spectroscopy (EDS). The corrosion resistance was evaluated through potentiodynamic polarization and electrochemical impedance spectroscopy (EIS) measurements conducted in simulated body fluid, while the degradation behavior of the samples was evaluated by examining the hydrogen evolution volume and corrosion morphology during immersion tests. The results indicate that the composite coating exhibits a dual-layer structure, consisting of an amorphous carbon–fluorine transition layer and an iron-rich surface layer. After coating treatment, the corrosion current density of magnesium alloy decreased from 1.38 × 10⁻⁴ to 3.41 × 10⁻⁶ A/cm². Throughout a 28-day immersion period, the composite-coated sample demonstrated a remarkably low hydrogen evolution rate and maintained a smooth, intact surface. Furthermore, hemolysis and platelet adhesion tests confirmed the outstanding blood compatibility of the composite-coated magnesium alloy, showing an ultralow hemolysis rate of 0.1% and minimal platelet adhesion with well-preserved morphology. Full article

The recent trend in analog design to replace typical analog circuits with digital implementations has led to the use of resistive feedback to pull a CMOS inverter into the switching threshold region to achieve gain, which is ideal for analog operations. Here, we report a three-transistor (3T) CMOS resistive-feedback inverter-based amplifier capable of achieving high gain paralleled with reduced noise, low power consumption, and enhanced stability. Unlike conventional resistive-feedback inverter-based amplifiers, the transistors are operated in the subthreshold region, which allows for a lower supply voltage and current, leading to lower power consumption. Subthreshold conduction also reduces typical amplifier noise sources. This design provides a novel approach to resistive feedback in the inverter amplifier, allowing for a large gain while occupying minimal layout area. The reported amplifier design facilitates unique capabilities, e.g., detection of ultra-low (fC) charges or sub-pA currents for newly emerging PHz electronic and optoelectronic devices driven by few-cycle laser pulses. As proof of concept, the specifications of the proposed amplifier are successfully measured and verified by multiple test chips designed and fabricated in TSMC’s 180 nm CMOS process. The fabricated amplifier operates at a 1.35 V power supply with a measured voltage gain of 53.61 dB (or 480 V/V), a bandwidth of 94 kHz, and an equivalent input voltage noise of 6.4 nV/$\sqrt{\mathrm{Hz}}$, consuming only 13.5 µW. Full article

This review is focused on the current status of quantitative MRI (qMRI) of skeletal muscle. The first section covers the techniques of qMRI in muscle with the focus on each quantitative parameter, the corresponding imaging sequence, discussion of the relation of the measured parameter to underlying physiology/pathophysiology, the image processing and analysis approaches, and studies on normal subjects. We cover the more established parametric mapping from T1-weighted imaging for morphometrics including image segmentation, proton density fat fraction, T2 mapping, and diffusion tensor imaging to emerging qMRI features such as magnetization transfer including ultralow TE imaging for macromolecular fraction, and strain mapping. The second section is a summary of current clinical applications of qMRI of muscle; the intent is to demonstrate the utility of qMRI in different disease states of the muscle rather than a complete comprehensive survey. Full article

One of the most advanced and versatile nanoscale diagnostic tools is atomic force microscopy. By enabling advanced imaging techniques, it allows us to determine various assets of a surface, including morphological, electrical, mechanical, magnetic, and thermal properties. Measuring local current flow is one of the very important methods of evaluation for, for instance, photovoltaic materials or semiconductor structures and other nanodevices. Due to contact areas, the current densities can easily reach above 1 kA/m²; therefore, special detection/measurement setups are required. They meet the required measurement range, sensitivity, noise level, and bandwidth at the measurement scale. Also, they prevent the sample from becoming damaged and prevent unwanted tip–sample issues. In this paper, we present three different nanoscale current measurement solutions, supported with test results, proving their performance. Full article

An ultra-low quiescent current output-capacitor-less low dropout (OCL-LDO) regulator for power-sensitive applications is proposed in this paper. To improve the gain of the OCL-LDO feedback loop, the error amplifier employs a combination of a cross-coupled input stage for boosting the equivalent input transconductance and a negative resistance technique to improve the gain. Meanwhile, in order to address the issue of transient response of the ultra-low quiescent current OCL-LDO, a sub-threshold slew-rate enhancement circuit is proposed in this paper, which consists of a transient signal input stage and a slew-rate current increase branch. The proposed OCL-LDO is fabricated in a 0.18 $\mu$m CMOS process with an effective area of 0.049 mm². According to the measurement results, the proposed OCL-LDO has a maximum load current of 100 mA and a minimum quiescent current of 640 nA at an input voltage of 1.2 V and an output voltage of 1 V. The overshoot and undershoot voltages are 197 mV and 201 mV, respectively, and the PSR of the OCL-LDO is −72.4 dB at 1 kHz when the load current is 100 $\mu$A. In addition, the OCL-LDO has a load regulation of 7.6 $\mu$V/mA and a line regulation of 0.87 mV/V. Full article

This paper presents the design of a bidirectional wireless power and information transfer system. The wireless information transfer is based on near-field technology, utilizing communication coils integrated into power transfer coils. Compared with conventional far-field-based communication methods (e.g., Bluetooth and WLAN), the proposed near-field-based communication method provides a peer-to-peer feature, as well as lower latency, which enables the simple paring of a transmitter and a receiver for power transfer and the real-time updating of control parameters. Using the established communication, control parameters are transmitted from one side of the system to another side, and the co-control of the inverter and the active rectifier is realized. In addition, this work innovatively presents the communication-signal-based synchronization of an inverter and a rectifier, which requires no AC current sensing in the power path and no complex algorithm for stabilization, unlike conventional current-based synchronization methods. The proposed information and power transfer system was measured under different operating conditions, including aligned and misaligned positions, operating points with different charging powers, and forward and reverse power transfer. The results show that the presented prototype allows a bidirectional power transfer of up to 1.2 kW, and efficiency above 90% for the power ranges from 0.6 kW to 1.2 kW was obtained. Furthermore, the integrated communication is robust to the crosstalk from the power transfer and misalignment, and a zero BER (bit error rate) and ultra-low latency of 15.36 µs are achieved. The presented work thus provides a novel solution to the synchronization and real-time co-control of an active rectifier and an inverter in a wireless power transfer system, utilizing integrated near-field-based communication. Full article

Graphing the consumption of daily essentials like electricity and water is crucial for minimising waste and estimating per-user usage in light of the modern-day data acquisition rally for a better understanding of customer consumption and patterns. Traditional methods of electrical measurement require the involvement of a trained professional, while more advanced alternatives can be prohibitively expensive or offer limited customisation options. We address the cost factor, flexibility, and complexity issues by using a non-intrusive clamp current transformer around power lines to measure current, estimate power, and upload it to the cloud with proper statistical data. For domestic and industrial applications, the filtered and referenced outputs are read by a low-cost CPU (ultra-low power) equipped with Wi-Fi, an analog-to-digital converter, and Bluetooth capabilities, which then determines the apparent power with an accuracy of 0.37 to 0.8%. Nonlinearity varies from 0.2% to 0.3% as a function of increasing current; nonetheless, offsets are imperceptible under typical operating conditions. Safety in the event of a sudden, large change in the current profile is one of several factors that determine the current measuring limit, together with the rating of the current transformer utilised and other related filtering, reference, calibration, and coding criteria. Our goal is to make the power consumption statistics accessible on the move at little cost by simplifying the circuit and coding of traditional metres. It is smart in that no hard coding is required to send credentials across routers, and fault signals are detected and relayed in accordance with an algorithm. User-specific servers save data for monitoring and conserving energy usage; users do not need to consult specialists or put their own security at risk. Data are acquired from the power line and sent to the cloud where statistical functions are performed to increase insight into consumption and failure. It has impressive range and accuracy in terms of power and current for residential and business applications. Full article

A low-power delay-locked loop (DLL)-based frequency multiplier is presented. The multiplier is designed in 22 nm FDSOI and achieves 8× multiplication. The proposed DLL uses a new simple duty cycle correction circuit and is XOR logic-based for frequency multiplication. Current starved delay cells are used to make the circuit power efficient. The circuit uses three 2× stages instead of an edge combiner to achieve 8× multiplication, thus requiring far less power and chip area as compared to conventional phase-locked loop (PLL) circuits. The proposed 8× multiplier occupies an active area of 0.09 mm². The measurement result shows ultra-low power consumption of 130 µW at 0.8 V supply. The post-layout simulation shows a timing jitter of 24 ps (pk-pk) at 2.44 GHz. Full article

Articular cartilage lacks intrinsic regenerative capabilities, and the current treatments fail to regenerate damaged tissue and lead only to temporary pain relief. These limitations have prompted the development of tissue engineering approaches, including 3D culture systems. Thanks to their regenerative properties and capacity to recapitulate embryonic processes, spheroids obtained from mesenchymal stromal cells are increasingly studied as building blocks to obtain functional tissues. The aim of this study was to investigate the capacity of adipose stromal cells to assemble in spheroids and differentiate toward chondrogenic lineage from the perspective of cartilage repair. Spheroids were generated by two different methods (3D chips vs. Ultra-Low Attachment plates), differentiated towards chondrogenic lineage, and their properties were investigated using molecular biology analyses, biophysical measurement of mass density, weight, and size of spheroids, and confocal imaging. Overall, spheroids showed the ability to differentiate by expressing specific cartilaginous markers that correlate with their mass density, defining a critical point at which they start to mature. Considering the spheroid generation method, this pilot study suggested that spheroids obtained with chips are a promising tool for the generation of cartilage organoids that could be used for preclinical/clinical approaches, including personalized therapy. Full article

Narrow-linewidth lasers have a high spectral purity, long coherent length, and low phase noise, so they have important applications in atomic clocks, precision measurement, and quantum computing. We inject a transmitted laser from a narrow-linewidth (∼15 kHz) flat-concave Fabry–Perot (F-P) cavity made from ultra-low expansion (ULE) optical glass into an 852 nm distributed Bragg reflector-type laser diode (DBR-LD), of which the comprehensive linewidth is 1.67 MHz for the free running case. With an increase in the self-injection power, the laser linewidth gradually narrows, and the injection locking current range gradually increases. The narrowest linewidth measured by the delayed frequency-shifted self-heterodyne (DFSSH) method is about 365 Hz, which is about $1/4500$ of the linewidth for the free running case. Moreover, to characterize the laser phase noise, we use a detuned F-P cavity to measure the conversion signal from the laser phase noise to the intensity noise for both the free running case and the self-injection lock case. The laser phase noise for the self-injection lock case is significantly suppressed in the analysis frequency range of 0.1–10 MHz compared to the free running case. In particular, the phase noise is suppressed by more than 30 dB at an analysis frequency of 100 kHz. Full article

There are increasing demands for the Internet of Things (IoT), wearable electronics, and medical implants. Wearable devices provide various important daily applications by monitoring real-life human activities. They demand low-cost autonomous operation in a miniaturized form factor, which is challenging to realize using a rechargeable battery. One promising energy source is thermoelectric generators (TEGs), considered the only way to generate a small amount of electric power for the autonomous operation of wearable devices. In this work, we propose a compact and efficient converter system for energy harvesting from TEGs. The system consists of an 83.7% efficient boost converter and a 90 mV self-startup, sharing a single inductor. Innovated techniques are applied to adaptive maximum power point tracking (A-MPPT) and indirect zero current switching (I-ZCS) controllers for efficient operation. The startup circuit is realized using a gain-boosted tri-state buffer, which achieves 69.8% improved gain at the input V_IN = 200 mV compared to the conventional approach. To extract the maximum power, we use an A-MPPT controller based on a simple capacitive divider, achieving 95.2% tracking efficiency. To address the challenge of realizing accurate voltage or current sensors, we propose an I-ZCS controller based on a new concept of maximum output voltage tracking (MOVT). The integrated circuit (IC) is fabricated using a 28 nm CMOS in a compact chip area of 0.03 mm². The compact size, which has not been obtained with previous designs, is suitable for wearable device applications. Measured results show successful startup operation at an ultralow input, V_IN = 90 mV. A peak conversion efficiency of 85.9% is achieved for the output of 1.07 mW. Full article

Slivers on the surface of rolled plates, which are serious defects for interstitial-free (IF) steel, occur mainly as a result of inclusions in continuous casting (CC) slabs. It is, therefore, important to study inclusions in CC slabs in terms of their migration towards the surface during hot rolling. To investigate inclusion migration during the hot rolling of ultralow carbon steel, a 3D numerical model was constructed using the finite element method. The positions of the inclusions in the surface layer of an IF steel slab (50 mm) were tracked during hot rolling using a node-tracking method. Furthermore, the study analyzed the effects of scarfing on inclusion migration during hot rolling and inclusion distribution in a hot-rolled plate. During the hot-rolling process, inclusions in the wide faces of the intermediate slab gradually migrated to the surface of the intermediate slab. Owing to a thickness reduction, accumulation areas of inclusions were finally generated at the edge of the hot-rolled plate; these areas may lead to sliver defects. The scarfing of the slab did not affect the distribution of inclusions in the hot-rolled plate; however, it may have reduced the inclusion content in the outermost layers of the hot-rolled plate. The inclusions were mainly located within 1 mm underneath the hot-rolled plate. Moreover, the inclusions near the inner arc of the CC slab were concentrated within 1.5 mm of the upper plate surface. Using galvanostatic electrolysis, the number of large inclusions in samples prepared from a hot-rolled plate obtained from a plant was measured. The measurements agreed well with the numerical model predictions, which validated the FE model in the current work. Full article

Biodiesel, which can be made from a variety of natural oils, is currently promoted as a sustainable, healthier replacement for commercial mineral diesel despite little experimental data supporting this. The aim of our research was to investigate the health impacts of exposure to exhaust generated by the combustion of diesel and two different biodiesels. Male BALB/c mice (n = 24 per group) were exposed for 2 h/day for 8 days to diluted exhaust from a diesel engine running on ultra-low sulfur diesel (ULSD) or Tallow or Canola biodiesel, with room air exposures used as control. A variety of respiratory-related end-point measurements were assessed, including lung function, responsiveness to methacholine, airway inflammation and cytokine response, and airway morphometry. Exposure to Tallow biodiesel exhaust resulted in the most significant health impacts compared to Air controls, including increased airway hyperresponsiveness and airway inflammation. In contrast, exposure to Canola biodiesel exhaust resulted in fewer negative health effects. Exposure to ULSD resulted in health impacts between those of the two biodiesels. The health effects of biodiesel exhaust exposure vary depending on the feedstock used to make the fuel. Full article

The quantitative detection of critical biomolecules and in particular low-abundance biomarkers in biofluids is crucial for early-stage diagnosis and management but remains a challenge largely owing to the insufficient sensitivity of existing ensemble-sensing methods. The single-particle imaging technique has emerged as an important tool to analyze ultralow-abundance biomolecules by engineering and exploiting the distinct physical and chemical property of individual luminescent particles. In this review, we focus and survey the latest advances in single-particle optical imaging (OSPI) for ultrasensitive bioanalysis pertaining to basic biological studies and clinical applications. We first introduce state-of-the-art OSPI techniques, including fluorescence, surface-enhanced Raman scattering, electrochemiluminescence, and dark-field scattering, with emphasis on the contributions of various metal and nonmetal nano-labels to the improvement of the signal-to-noise ratio. During the discussion of individual techniques, we also highlight their applications in spatial–temporal measurement of key biomarkers such as proteins, nucleic acids and extracellular vesicles with single-entity sensitivity. To that end, we discuss the current challenges and prospective trends of single-particle optical-imaging-based bioanalysis. Full article