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Dr. Roxana Surugiu
Experimental Research Center for Normal and Pathological Aging, University of Medicine and Pharmacy Craiova, 200349 Craiova, Romania
1. Chair of Vascular Neurology and Dementia, Essen University Medical School, Essen, Germany
2. Experimental Research Center for Normal and Pathological Aging Director, University of Medicine and Pharmacy of Craiova, Craiova, Romania
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Brain Plasticity Across the Lifespan: Development, Aging, and Implications for Cerebrovascular Health

Abstract submission deadline
closed (31 August 2025)
Manuscript submission deadline
31 October 2025
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2167

Topic Information

Dear Colleagues,

Brain plasticity is a remarkable property of the nervous system that remains dynamic throughout our lives, influencing how we learn, adapt to new experiences, and recover from injury. Early developmental stages showcase high degrees of plasticity, where the brain rapidly builds new connections, refines neural networks, and lays the groundwork for lifelong cognitive functions. As we age, this adaptability evolves, and while it may decline in some areas, it does not disappear; instead, the brain employs compensatory strategies to maintain function, emphasizing the importance of ongoing stimulation and healthy lifestyle choices. Crucially, cerebrovascular health—encompassing blood flow, vessel integrity, and overall cardiovascular fitness—underpins our brain’s ability to harness plasticity effectively. Age-related vascular changes, such as reduced cerebral blood flow or increased risk of stroke, can compromise plasticity and accelerate cognitive decline. By supporting vascular health through regular exercise, balanced nutrition, stress management, and prompt medical care for vascular risk factors, we maximize the potential for our brains to adapt, learn, and remain resilient across the lifespan.

Dr. Roxana Surugiu
Prof. Dr. Aurel Popa-Wagner
Topic Editors

Keywords

  • brain plasticity
  • nervous system
  • cerebrovascular health
  • brain
  • cognitive decline

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
BioChem
biochem 		- - 2021 33.9 Days CHF 1000 Submit
Biomolecules
biomolecules 		4.8 9.2 2011 19.4 Days CHF 2700 Submit
International Journal of Molecular Sciences
ijms 		4.9 9.0 2000 20.5 Days CHF 2900 Submit
NeuroSci
neurosci 		2.0 - 2020 27.1 Days CHF 1200 Submit

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Published Papers (1 paper)

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31 pages, 1203 KB  
Perspective
Theoretical Framework and Methodological Approach for Investigating Potential Associations Between Long COVID and Autism Spectrum Disorder Prevalence
by Thorsten Rudroff
NeuroSci 2025, 6(3), 80; https://doi.org/10.3390/neurosci6030080 - 13 Aug 2025
Viewed by 1455
Abstract
This perspective paper proposes a theoretical framework for investigating potential associations between Long COVID and rising autism spectrum disorder (ASD) prevalence through established epidemiological methodologies. I propose examining temporal correlations, biological mechanisms, and rigorous methodological approaches, including Mendelian randomization, animal models, and evidence-based [...] Read more.
This perspective paper proposes a theoretical framework for investigating potential associations between Long COVID and rising autism spectrum disorder (ASD) prevalence through established epidemiological methodologies. I propose examining temporal correlations, biological mechanisms, and rigorous methodological approaches, including Mendelian randomization, animal models, and evidence-based analyses, that could distinguish association from causation. The proposed framework recognizes autism as neurodiversity while suggesting investigation of environmental factors that may influence expression of genetic predispositions. Hypothesized key mechanisms include neuroinflammation, cytokine alterations, and immune dysfunction. I emphasize the critical distinction between demonstrating statistical associations and establishing causal influence, proposing specific experimental designs that could test causality. This paper presents conceptual frameworks requiring future empirical validation and does not include original data analysis. Full article
(This article belongs to the Topic Brain Plasticity Across the Lifespan: Development, Aging, and Implications for Cerebrovascular Health)
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