Cell Signaling and Redox Biology: From Molecular Mechanisms to Therapeutic Applications

Topic Information

Dear Colleagues,

Cell signaling events and pathways control a cell’s environmental perception and subsequent functioning. It is now apparent that redox biology is part of the suite of mechanisms which orchestrate signaling events in cells. Internally, the redox status of a cell is held at a reducing level and is finely controlled in a balanced manner. This is achieved by the presence of many small redox-active molecules, such as glutathione and ascorbate, but also by a number of dietary antioxidants, such as vitamin E, and by antioxidant enzymes such as superoxide dismutase and catalase. Numerous small reactive molecules can be generated, and their metabolism can maintain or disrupt the redox balance of cells. These include reactive oxygen species (ROS), such as hydrogen peroxide (H₂O₂), reactive nitrogen species (RNS), such as nitric oxide (NO), and reactive sulfur species (RSS), such as hydrogen sulfide (H₂S). Redox mechanisms can control the action of proteins through covalent modifications, for example, by S-nitrosylation, therefore controlling cellular activities. Cell growth, development, and death, for example, through apoptosis, can all be controlled, in part, by redox metabolism. Redox dysfunction has been associated with a range of stress responses and diseases, both in plants and animals. Redox events can be used in pathogen control, as well as cellular dysfunction, through nitro-oxidative stress. Diseases such as Parkinson’s, Alzheimer’s, and other neurodegenerative diseases often have an element of redox imbalance, as does diabetes. The aging process also involves redox metabolism. Therefore, an understanding of the molecular mechanisms of redox biology and how therapeutics and treatments can be used to manipulate cellular redox is important. This Topic aims to bring together an array of cutting-edge research articles on redox biology from a range of organisms, from plants and nematodes to humans. Papers may be primary research articles or reviews. Interdisciplinary research is particularly welcomed, as are opinion articles suggesting ways to navigate bottlenecks in the field.

Prof. Dr. John T. Hancock
Prof. Dr. Sergej M. Ostojic
Prof. Dr. Jiankang Liu
Dr. Juan de Dios Alché Ramírez
Topic Editors

Keywords

Participating Journals

Journal Name	Impact Factor	CiteScore	Launched Year	First Decision (median)	APC
Antioxidants antioxidants	6.6	12.4	2012	17.4 Days	CHF 2900	Submit
Biology biology	3.5	7.4	2012	17.4 Days	CHF 2700	Submit
Nitrogen nitrogen	2.3	2.8	2020	19.7 Days	CHF 1200	Submit
Oxygen oxygen	-	8.4	2021	24 Days	CHF 1000	Submit
Clinical Bioenergetics clinbioenerg	-	-	2025	15.0 days *	CHF 1000	Submit
Plants plants	4.1	7.6	2012	17.7 Days	CHF 2700	Submit
Biomedicines biomedicines	3.9	6.8	2013	17 Days	CHF 2600	Submit

* Median value for all MDPI journals in the first half of 2025.

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