Topic Editors

Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Naples, Italy
Department of Molecular Medicine and Medical Biotechnology, University of Naples "Federico II", Via S. Pansini 5, 80131 Napoli, Italy

Multi-Omics in Precision Medicine

Abstract submission deadline
31 October 2025
Manuscript submission deadline
31 December 2025
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Topic Information

Dear Colleagues,

Precision medicine embraces the power to predict the most suitable treatment strategy for patients affected by complex diseases, thus improving medical and public health management. This ap-proach moves through the definition of multi-omics profiles in combination with patients’ clinical data with the final goal of determining disease susceptibility or discovering diagnostic, prognostic, and predictive biomarkers. Starting from single patients, it is possible to develop predictive models to identify early risk or identify therapeutic strategies and knowledge bases for predictive and per-sonalized healthcare in diverse populations. These aims can be easily fulfilled owing to the high fea-sibility of collecting omics data, including genomics, proteomics, and metabolomics. Furthermore, artificial intelligence and machine-learning algorithms improve precision medicine by leveraging and extending the value of original data. In fact, through integration procedures, pa-tient-specific multi-omics profiles can be modelled against public data repositories and annotation databases to obtain new insights or shape existing knowledge into disease mechanisms. This Topic will include emerging and significant advances in multi-omics strategies for implement-ing precision medicine, welcoming research papers, reviews, and communications based on exper-imental in addition to in silico characterization of multi-omics datasets and the management of big data.

Dr. Michele Costanzo
Dr. Armando Cevenini
Topic Editors

Keywords

  • precision medicine
  • multi-omics
  • personalized therapy
  • proteomics
  • metabolomics
  • machine learning
  • artificial intelligence

Participating Journals

Journal Name Impact Factor CiteScore Launched Year First Decision (median) APC
Biomedicines
biomedicines
3.9 6.8 2013 17 Days CHF 2600 Submit
Metabolites
metabolites
3.7 6.9 2011 14.4 Days CHF 2700 Submit
Proteomes
proteomes
3.6 7.2 2013 28.2 Days CHF 1800 Submit
Genes
genes
2.8 5.5 2010 14.6 Days CHF 2600 Submit
J
J
- - 2018 37.2 Days CHF 1200 Submit

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Published Papers (1 paper)

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31 pages, 1277 KB  
Review
Extracellular Vesicle (EV) Proteomics in Corneal Regenerative Medicine
by Zohreh Arabpour, Hanieh Niktinat, Firouze Hatami, Amal Yaghmour, Zarife Jale Yucel, Seyyedehfatemeh Ghalibafan, Hamed Massoumi, Zahra Bibak Bejandi, Majid Salehi, Elmira Jalilian, Mahmood Ghassemi, Victor H. Guaiquil, Mark Rosenblatt and Ali R. Djalilian
Proteomes 2025, 13(4), 49; https://doi.org/10.3390/proteomes13040049 - 3 Oct 2025
Abstract
Corneal regeneration has gained growing interest in recent years, largely due to the limitations of conventional treatments and the persistent shortage of donor tissue. Among the emerging strategies, extracellular vehicles (EVs), especially those derived from mesenchymal stromal cells (MSCs), have shown great promise [...] Read more.
Corneal regeneration has gained growing interest in recent years, largely due to the limitations of conventional treatments and the persistent shortage of donor tissue. Among the emerging strategies, extracellular vehicles (EVs), especially those derived from mesenchymal stromal cells (MSCs), have shown great promise as a cell-free therapeutic approach. These nanoscale vesicles contribute to corneal healing by modulating inflammation, supporting epithelial and stromal regeneration, and promoting nerve repair. Their therapeutic potential is largely attributed to the diverse and bioactive proteomic cargo they carry, including growth factors, cytokines, and proteins involved in extracellular matrix remodeling. This review presents a comprehensive examination of the proteomic landscape of EVs in the context of corneal regenerative medicine. We explore the biological functions of EVs in corneal epithelial repair, stromal remodeling, and neurodegeneration. In addition, we discuss advanced proteomic profiling techniques such as mass spectrometry (MS) and liquid chromatography–mass spectrometry (LC-MS/MS), which have been used to identify and characterize the protein contents of EVs. This review also compares the proteomic profiles of EVs derived from various MSC sources, including adipose tissue, bone marrow, and umbilical cord, and considers how environmental cues, such as hypoxia and inflammation, influence their protein composition. By consolidating current findings, this article aims to provide valuable insights for advancing the next generation of cell-free therapies for corneal repair and regeneration. Full article
(This article belongs to the Topic Multi-Omics in Precision Medicine)
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