Molecules, Volume 4, Issue 10

Teaching organic chemistry is a challenging task and tools which allow students to understand what is happening during an organic reaction are really difficult to find.[...]

This book is an important monograph for those working on the related structural chemistry of the weak hydrogen bond.[...]

Trimethylsilyl enol ethers of 1,3-diketones are generated “in situ” or obtained in high isolated yield by the reaction of 1,3-diketones with trimethylcyanosilane in various solvents such as cyclohexane, hexane, benzene, methylene chloride, chloroform...

Methylphosphonic acid monoesters have been explored for many different purposes [1, 2].[...]

The title compound was prepared from 5 g (89 mmol, 1 eq) of (3R,4R)-2,5-dimethoxy-2,5-dimethyl- 3,4-hexanediol [1], 4.4 ml (3.95 g, 27 mmol, 1.1 eq) of triethyl orthoformate, 0.05 g (0.25 mmol, 0.01 eq) of p-toluenesulfonic acid monohydrate in 35 ml...

The general part of the experimental section [1] was presented elsewhere.[...]

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised in a model reaction from 3-phenyl-2-propynoyl isocyanate (2) and ethanol. Isocyanate 2 was generated in situ from the corresponding carb...

The general part of the experimental section [1] has been presented elsewhere.[...]

During the synthesis of a series of carboximides using acyl isocyanates [1], the title compound 3 was synthesised as a model compound from benzoyl isocyanate (1) and lithium phenylacetylide (2).[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere.[...]

The general part of the experimental section [1] has been presented elsewhere. To a boiling solution of 4,5-dimethoxy-4-nitrobenzophenone (10.0 g, 35 mmol) in ethanol (85 ml), NaBH₄ (0.61 g) was added gradually.

A solution of 5-nitroisophthaloyl dichloride (1) [1] (3.92 g, 15.8 mmol) and 4-tert-butylbenzhydrazide (2) [2] (6.08 g, 31.6 mmol) in CHCl₃ (70 mL) was heated to reflux for 12 h.[...]

The reduction was carried out as described in reference [1] by using a mixture of sulfur (7.10 g, 0.22 mol), Na₂S — 9 H₂O (240 g, 0.22 mol), water (140 mL) and pyridine (20 mL).[...]

Synthesis of purines and purine mono-1-oxides from the respective 5-substituted 4-nitroimidazole derivatives is described. The commercially available 4-nitroimidazole, in a few simple steps (including Vicarious Nucleophilic Substitution of Hydrogen),...

The title 3-amino-2-thiohydantoins 3 has been prepared in very good yields by the reaction of alkyl isothiocynatocarboxylates 1 with hydrazine hydrate.The synthesis of starting isothiocyanates as well as spectral data of 3-aminothiohydantoins and alk...

The thermal and acid-catalyzed intramolecular rearrangement of the (Z)- and (E)-cyclodecene-1,4-dione compounds deriving from steroids, 2a,b and 3a,b, respectively, proceeds stereoselectively to give the corresponding configurationally different spir...

Substitution of 4-methyl-[1,8]-naphthyridine in 2 and 7 position by alkylamines leads to highly fluorescent compounds. The arrangement of hydrogen donor and acceptor groups of these naphthyridines allows interactions with guanine and guanine cytosine...