Table of Contents
Materials, Volume 9, Issue 12 (December 2016)
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Cover Story Synthetic and natural ligands that bind IgG are detailed in this paper. Bacterial proteins such as [...] Read more. Synthetic and natural ligands that bind IgG are detailed in this paper. Bacterial proteins such as Protein G, A, and L are traditionally used as affinity ligands for antibody purification. Small synthetic Fc-binding peptides (FcBPs) are emerging as promising alternatives to bacterial proteins. The figure shows that a humanized IgG, trastuzumab, is complexed onto clustered FcBPs on a protein nanocage which is formed by self-assembly of 24 ferritin monomers carrying a C-terminal FcBP.