Table of Contents
J. Clin. Med., Volume 6, Issue 12 (December 2017)
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Cover Story (view full-size image) The cover image summarizes how mucin production is altered between health and fatal asthma. MUC5AC [...] Read more. The cover image summarizes how mucin production is altered between health and fatal asthma. MUC5AC and MUC5B are the principal components of airway mucus. Recent evidence has begun to unveil their contribution to health and asthma. We review our current understanding of the role of MUC5AC and MUC5B in asthma. We discuss how MUC5AC and MUC5B share sequence and structure similarity, but their glycosylation, localization and function differ. We summarize how MUC5AC and MUC5B production is altered in asthma, discuss changes in goblet cell number and how these changes contribute to mucus plugging through MUC5AC tethering. We also discuss how commonly used asthma therapies and cytokine-specific antibodies may serve in part as mucoregulators. View the paper