Table of Contents
Bioengineering, Volume 4, Issue 2 (June 2017)
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Cover Story Biotinylation and multivalent presentation of N-acetyllactosamine- and [...] Read more. Biotinylation and multivalent presentation of N-acetyllactosamine- and N’,N’’-diacetyllactosamine-based tetrasaccharides affect galectin-3 binding positively. Biotin conjugation to the C6-position of the terminal sugar leads to high-affinity ligands with selectivity for galectin-3 over galectin-1. The inhibitory potential is significantly increased when glycans are presented on serum albumin. These biotinylated neo-glycoproteins are promising candidates for targeting galectin-3 and open new possibilities for galectin inhibitor design in cancer research.