Antioxidant Capability and Physical Exercise in Neurobiology: A Focus in Neurodegeneration II
A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".
Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 2100
Special Issue Editor
Interests: oxidative stress; brain function; neurodegeneration; antioxidant capability; physical exercise
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Neurodegenerative processes have been linked not only to genetic factors, but also to environmental ones. Among these, a pivotal role has been largely attributed to oxidative stress, which arises from an imbalance between an excessive generation of reactive oxygen species (ROS) and the biological system’s capability to eliminate the reactive intermediates. Oxidative stress leads to a progressive decline in cell physiology by damaging cellular macromolecular components such as DNA, lipids, and proteins.
Several studies have demonstrated that regular exercise is an important preventive and therapeutic tool in neurodegeneration and cerebrovascular diseases. The adaptive response to regular exercise involves the upregulation of the enzymatic antioxidant system and modulation of oxidative damage, which culminate in a recovered redox state of brain cells. In addition to a reduction in oxidative damage, the effects of exercise seem to be quite intricate, including an increase in neurogenesis and capillarization and an enhanced proteolytic degradation of toxic oligomers that characterize aging and neurodegenerative processes. All together, these data highlight the link between neurodegeneration, oxidative stress, and physical exercise.
This Special Issue aims to provide an overview of the current knowledge on the physiological, metabolic, and epigenetic modifications in response to physical activity and its final effects on brain functionality, both in physiological and in pathological conditions.
Potential topics include, but are not limited to, the following:
- Studies of the cellular and molecular mechanisms associated with oxidative stress in neurodegenerative diseases;
- Clinical or preclinical studies showing physical exercise properties in brain functionality.
Dr. Ferdinando Franzoni
Guest Editor
Manuscript Submission Information
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Keywords
- physical exercise
- oxidative stress
- brain function
- neurodegeneration
- antioxidant capability
