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Journals
Antioxidants
Special Issues
Redox Modulation of Respiratory Muscles in Health and Disease
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Redox Modulation of Respiratory Muscles in Health and Disease

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (15 December 2019) | Viewed by 3708

Special Issue Editors

Prof. Ken O'Halloran

E-Mail Website
Guest Editor
Department of Physiology, University College Cork, Cork, Ireland
Interests: control of breathing; respiratory muscle; hypoxia; redox balance
Special Issues, Collections and Topics in MDPI journals
Dr. David Burns

E-Mail Website
Guest Editor
Department of Physiology, University College Cork, Cork, Ireland
Interests: neuromuscular disease; control of breathing; oxidative stress; muscular dystrophy

Special Issue Information

Dear Colleagues,

Redox disturbance is a common feature of respiratory disorders such as obstructive sleep apnoea and chronic obstructive pulmonary disorder. Perturbed redox signalling as a result of increased reactive oxygen species production or decreased endogenous antioxidant capacity can lead to adaptive and maladaptive changes in cellular function. In the context of respiratory muscle, redox imbalance can disrupt cellular homeostasis, culminating in diminished respiratory muscle force-generating capacity and decreased resistance to fatigue. Strategies aimed at promoting redox balance in respiratory muscles are attractive as adjunctive therapies for respiratory disease.
This Special Issue welcomes original research articles and literature reviews concerning respiratory muscle redox modulation and novel approaches aimed at targeting redox imbalance across the spectrum of health and disease.

Prof. Ken O'Halloran
Dr. David Burns
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Oxidative stress
  • Respiratory muscle
  • Antioxidants
  • Redox signaling
  • Respiratory disease
  • Reactive oxygen species

Published Papers (1 paper)

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Research

26 pages, 1893 KiB  
Article
N-acetylcysteine Decreases Fibrosis and Increases Force-Generating Capacity of mdx Diaphragm
by David P. Burns, Sarah E. Drummond, Dearbhla Bolger, Amélie Coiscaud, Kevin H. Murphy, Deirdre Edge and Ken D. O’Halloran
Antioxidants 2019, 8(12), 581; https://doi.org/10.3390/antiox8120581 - 24 Nov 2019
Cited by 24 | Viewed by 3471
Abstract
Respiratory muscle weakness occurs due to dystrophin deficiency in Duchenne muscular dystrophy (DMD). The mdx mouse model of DMD shows evidence of impaired respiratory muscle performance with attendant inflammation and oxidative stress. We examined the effects of N-acetylcysteine (NAC) supplementation on respiratory system [...] Read more.
Respiratory muscle weakness occurs due to dystrophin deficiency in Duchenne muscular dystrophy (DMD). The mdx mouse model of DMD shows evidence of impaired respiratory muscle performance with attendant inflammation and oxidative stress. We examined the effects of N-acetylcysteine (NAC) supplementation on respiratory system performance in mdx mice. Eight-week-old male wild type (n = 10) and mdx (n = 20) mice were studied; a subset of mdx (n = 10) received 1% NAC in the drinking water for 14 days. We assessed breathing, diaphragm, and external intercostal electromyogram (EMG) activities and inspiratory pressure during ventilatory and non-ventilatory behaviours. Diaphragm muscle structure and function, cytokine concentrations, glutathione status, and mRNA expression were determined. Diaphragm force-generating capacity was impaired in mdx compared with wild type. Diaphragm muscle remodelling was observed in mdx, characterized by increased muscle fibrosis, immune cell infiltration, and central myonucleation. NAC supplementation rescued mdx diaphragm function. Collagen content and immune cell infiltration were decreased in mdx + NAC compared with mdx diaphragms. The cytokines IL-1β, IL-6 and KC/GRO were increased in mdx plasma and diaphragm compared with wild type; NAC decreased systemic IL-1β and KC/GRO concentrations in mdx mice. We reveal that NAC treatment improved mdx diaphragm force-generating capacity associated with beneficial anti-inflammatory and anti-fibrotic effects. These data support the potential use of NAC as an adjunctive therapy in human dystrophinopathies. Full article
(This article belongs to the Special Issue Redox Modulation of Respiratory Muscles in Health and Disease)
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