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Antioxidants
Special Issues
Dietary Antioxidants and Health Promotion
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Dietary Antioxidants and Health Promotion

A special issue of Antioxidants (ISSN 2076-3921). This special issue belongs to the section "Health Outcomes of Antioxidants and Oxidative Stress".

Deadline for manuscript submissions: closed (30 April 2017) | Viewed by 84267

Special Issue Editor

Dr. Dejian Huang

E-Mail Website
Guest Editor
Food Science & Technology Programme, c/o Department of Chemistry, 3 Science Drive 3, Faculty of Science, National University of Singapore, Singapore 117543, Singapore
Interests: fabrication of quantum dots; transition metal complex; polyphenolic compounds; antioxidant; pro-oxidant activity
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

In light of the rapid development of dietary antioxidant research, we are delighted to call for papers to be published in this Special Issue. The scope of papers will include:

  • Clinical trials of dietary antioxidants on health promotions and disease preventions.
  • Animal model studies on the intervention study of dietary antioxidants on promotion of health status and reduce the chronic disease biomarkers particularly those on chronic inflammation, cardiovascular disease, diabetes, cancer, and Alzheimer disease.
  • Isolation, structural characterization of novel dietary antioxidants and their action mechanism.
  • Reaction kinetics, product characterization, and structure and activity relationship of dietary antioxidants in scavenging biologically relevant reactive oxygen species.
  • Analytical methodology on dietary antioxidant activity measurements in chemical and cellular systems.
  • Novel extraction and separation methods of dietary antioxidants.
  • Dietary antioxidant enriched functional foods and their health promotion related research.

I look forward to your contribution.

Prof. Dr. Dejian Huang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Antioxidants is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Antioxidant
  • Reactive oxygen species
  • Oxidative stress
  • Inflammation
  • Functional foods
  • Structure and activity relationship

Published Papers (7 papers)

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Editorial

Jump to: Research, Review

3 pages, 157 KiB  
Editorial
Dietary Antioxidants and Health Promotion
by Dejian Huang
Antioxidants 2018, 7(1), 9; https://doi.org/10.3390/antiox7010009 - 12 Jan 2018
Cited by 56 | Viewed by 8651
Abstract
Accumulating scientific evidence suggests that over-production of reactive oxygen species (ROS) may be the root cause of chronic diseases such as cancer, cardiovascular diseases, neurodegeneration, and ageing per se [1,2].[...] Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)

Research

Jump to: Editorial, Review

1449 KiB  
Article
Evaluating Modern Techniques for the Extraction and Characterisation of Sunflower (Hellianthus annus L.) Seeds Phenolics
by Panagiotis Zoumpoulakis, Vassilia J. Sinanoglou, Eleni Siapi, George Heropoulos and Charalampos Proestos
Antioxidants 2017, 6(3), 46; https://doi.org/10.3390/antiox6030046 - 24 Jun 2017
Cited by 21 | Viewed by 6748
Abstract
Recently there is a great interest in using high energy techniques (HET) which involve microwave or ultrasound-assisted extraction (MAE and UAE) for isolation of natural bioactive compounds from plant foods. Such bioactive compounds are phenolics which were determined from sunflower (Helianthus annuus [...] Read more.
Recently there is a great interest in using high energy techniques (HET) which involve microwave or ultrasound-assisted extraction (MAE and UAE) for isolation of natural bioactive compounds from plant foods. Such bioactive compounds are phenolics which were determined from sunflower (Helianthus annuus L.) kernels and hulls (defatted) utilising two different high energy extraction techniques, ultrasound and microwave assisted solvent extraction. All samples were characterised by ultra-high-performance liquid chromatography-electrospray ionization-mass spectrometry (UHPLC-ESI-MS). The effect of parameters such as the nature of the solvent, volume of solvent, temperature and time is discussed. It is proved that the techniques applied had reduced solvent consumption and shorter extraction times, and extraction yields of the analytes were equal to or to some extent higher than those obtained with conventional techniques. Total Phenolic Composition (TPC) of samples examined was studied by the Folin-Ciocalteu method and results were presented in μg gallic acid equivalents (GAE)/g dry extract. Kernels proved to have the higher amount of TPC while the press residues had shown comparable TPC results. The antioxidant activity of samples was spectrophotometrically determined by 2,2-Diphenyl-1-Picrylhydrazyl (DPPH) assay using Butylated hydroxyl toluene (BHT) as reference compound to compare with samples. Sunflower seeds (kernels) showed again the highest antiradical efficiency (AE) compared to hulls and press-residue extract. Afterwards, ferric reducing ability of plasma (FRAP) and trolox equivalent antioxidant capacity (TEAC) assays were used for measuring the antioxidant capacity of samples. Press residue, a by-product of sunflower oil extraction, contained phenolics as shown by UHPLC-ESI-MS analysis. Hence, later on these compounds can be possibly utilised by food or neutraceutical industries. Phenolic substances characterised in hulls, kernels, and press residue were phenolic acids, mainly chlorogenic, caffeic, cinnamic, 4-hydroxybenzoic and p-coumaric. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
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3257 KiB  
Article
Proanthocyanidin Characterization and Bioactivity of Extracts from Different Parts of Uncaria tomentosa L. (Cat’s Claw)
by Mirtha Navarro-Hoyos, Rosa Lebrón-Aguilar, Jesús E. Quintanilla-López, Carolina Cueva, David Hevia, Silvia Quesada, Gabriela Azofeifa, M. Victoria Moreno-Arribas, María Monagas and Begoña Bartolomé
Antioxidants 2017, 6(1), 12; https://doi.org/10.3390/antiox6010012 - 04 Feb 2017
Cited by 27 | Viewed by 8934
Abstract
Apart from alkaloids, bioactive properties of Uncaria tomentosa L. have been attributed to its phenolic constituents. Although there are some reports concerning low-molecular-weight polyphenols in U. tomentosa, its polymeric phenolic composition has been scarcely studied. In this study, phenolic-rich extracts from leaves, [...] Read more.
Apart from alkaloids, bioactive properties of Uncaria tomentosa L. have been attributed to its phenolic constituents. Although there are some reports concerning low-molecular-weight polyphenols in U. tomentosa, its polymeric phenolic composition has been scarcely studied. In this study, phenolic-rich extracts from leaves, stems, bark and wood (n = 14) of Uncaria tomentosa plants from several regions of Costa Rica were obtained and analysed in respect to their proanthocyanidin profile determined by a quadrupole-time-of-flight analyser (ESI-QTOF MS). Main structural characteristics found for U. tomentosa proanthocyanidins were: (a) monomer composition, including pure procyanidins (only composed of (epi)catechin units) and propelargonidins (only composed of (epi)afzelechin units) as well as mixed proanthocyanidins; and (b) degree of polymerization, from 3 up to 11 units. In addition, U. tomentosa phenolic extracts were found to exhibit reasonable antioxidant capacity (ORAC (Oxygen Radical Absorbance Capacity) values between 1.5 and 18.8 mmol TE/g) and antimicrobial activity against potential respiratory pathogens (minimum IC50 of 133 µg/mL). There were also found to be particularly cytotoxic to gastric adenocarcinoma AGS and colon adenocarcinoma SW620 cell lines. The results state the particularities of U. tomentosa proanthocyanidins and suggest the potential value of these extracts with prospective use as functional ingredients. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
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Review

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308 KiB  
Review
The Role of Food Antioxidants, Benefits of Functional Foods, and Influence of Feeding Habits on the Health of the Older Person: An Overview
by Douglas W. Wilson, Paul Nash, Harpal Singh Buttar, Keith Griffiths, Ram Singh, Fabien De Meester, Rie Horiuchi and Toru Takahashi
Antioxidants 2017, 6(4), 81; https://doi.org/10.3390/antiox6040081 - 28 Oct 2017
Cited by 142 | Viewed by 18070
Abstract
This overview was directed towards understanding the relationship of brain functions with dietary choices mainly by older humans. This included food color, flavor, and aroma, as they relate to dietary sufficiency or the association of antioxidants with neurodegenerative diseases such as dementia and [...] Read more.
This overview was directed towards understanding the relationship of brain functions with dietary choices mainly by older humans. This included food color, flavor, and aroma, as they relate to dietary sufficiency or the association of antioxidants with neurodegenerative diseases such as dementia and Alzheimer’s disease. Impairment of olfactory and gustatory function in relation to these diseases was also explored. The role of functional foods was considered as a potential treatment of dementia and Alzheimer’s disease through inhibition of acetylcholinesterase as well as similar treatments based on herbs, spices and antioxidants therein. The importance of antioxidants for maintaining the physiological functions of liver, kidney, digestive system, and prevention of cardiovascular diseases and cancer has also been highlighted. Detailed discussion was focused on health promotion of the older person through the frequency and patterns of dietary intake, and a human ecology framework to estimate adverse risk factors for health. Finally, the role of the food industry, mass media, and apps were explored for today’s new older person generation. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
3173 KiB  
Review
Antioxidant Activity of Spices and Their Impact on Human Health: A Review
by Alexander Yashin, Yakov Yashin, Xiaoyan Xia and Boris Nemzer
Antioxidants 2017, 6(3), 70; https://doi.org/10.3390/antiox6030070 - 15 Sep 2017
Cited by 286 | Viewed by 27699
Abstract
Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in food and beverages to enhance flavor, aroma and color. Due to their excellent antioxidant activity, spices and [...] Read more.
Antioxidants are substances that prevent oxidation of other compounds or neutralize free radicals. Spices and herbs are rich sources of antioxidants. They have been used in food and beverages to enhance flavor, aroma and color. Due to their excellent antioxidant activity, spices and herbs have also been used to treat some diseases. In this review article, the chemical composition and antioxidant activity of spices and culinary herbs are presented. The content of flavonoids and total polyphenols in different spices and herbs are summarized. The applications of spices and their impacts on human health are briefly described. The extraction and analytical methods for determination of antioxidant capacity are concisely reviewed. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
211 KiB  
Review
Vitamin E and Alzheimer’s Disease—Is It Time for Personalized Medicine?
by Breana Cervantes and Lynn M. Ulatowski
Antioxidants 2017, 6(3), 45; https://doi.org/10.3390/antiox6030045 - 24 Jun 2017
Cited by 32 | Viewed by 6928
Abstract
For the last two decades, it has been hotly debated whether vitamin E—the major lipid-soluble antioxidant, which functions to maintain neurological integrity—is efficacious as a therapy for Alzheimer’s disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin [...] Read more.
For the last two decades, it has been hotly debated whether vitamin E—the major lipid-soluble antioxidant, which functions to maintain neurological integrity—is efficacious as a therapy for Alzheimer’s disease. Several factors key to the debate, include (1) which of the eight naturally-occurring vitamin E forms should be used; (2) how combination treatments affect vitamin E efficacy; and (3) safety concerns that most-recently resurfaced after the results of the Selenium and vitamin E Cancer prevention trial SELECT prostate cancer trial. However, with the advent of new genetic technologies and identifications of vitamin E-modulating single nucleotide polymorphisms (SNPs), we propose that clinical trials addressing the question “Is vitamin E an effective treatment for Alzheimer’s disease” should consider a more focused and personalized medicine approach to designing experiments. An individual’s naturally-occurring SNP variants may indeed influence vitamin E’s therapeutic effect on Alzheimer’s disease. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
678 KiB  
Review
Undernutrition and Overnutrition Burden for Diseases in Developing Countries: The Role of Oxidative Stress Biomarkers to Assess Disease Risk and Interventional Strategies
by Francesca Mastorci, Cristina Vassalle, Kyriazoula Chatzianagnostou, Claudio Marabotti, Khawer Siddiqui, Ahmed Ould Eba, Soueid Ahmed Sidi Mhamed, Arun Bandopadhyay, Marco Stefano Nazzaro, Mirko Passera and Alessandro Pingitore
Antioxidants 2017, 6(2), 41; https://doi.org/10.3390/antiox6020041 - 08 Jun 2017
Cited by 19 | Viewed by 6544
Abstract
The increased life expectancy, urbanization, and unhealthy lifestyle characterized by a shift towards a sedentary lifestyle and decreased energy expenditure are considered the main drivers of epidemiological transition. In particular, developing countries are facing a double burden caused by coexisting under- and over-nutrition, [...] Read more.
The increased life expectancy, urbanization, and unhealthy lifestyle characterized by a shift towards a sedentary lifestyle and decreased energy expenditure are considered the main drivers of epidemiological transition. In particular, developing countries are facing a double burden caused by coexisting under- and over-nutrition, which causes a change in the disease profile from infectious diseases to a chronic degenerative pattern. This review discusses the under- and over-nutrition context in Mauritania and India, two countries that are experiencing a nutritional transition, and where we began a collaboration with local medical staff to integrate interventional and diagnostic guidelines. If many studies about diet and its relationship to non-communicable diseases are available for India, very few nutrition and cardiovascular risk studies have been conducted in Mauritania. Presently, with the exponential increase of nutrition-related diseases, targeted approaches are needed to provide balanced diets in parallel with the development of national preventive health systems and screening programs adapted to local needs. In this context, the measurement of oxidative stress biomarkers could be promising as an additive tool to assess cardiovascular (CV) risk in general population, and ameliorating prevention in patients at CV risk or with overt CV disease. Moreover, the possibility of improving the outcome by the direct employment of antioxidant remains plausible. Moreover, studies on the content of antioxidant in different foods may be helpful to develop a balanced diet, and achieve the maximal nutritional and functional properties of cultivars with benefits for human health. Full article
(This article belongs to the Special Issue Dietary Antioxidants and Health Promotion)
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