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Cells
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Cellular Biology Research in Adipose Progenitor Cells, Adipocytes and Adipose...
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Cellular Biology Research in Adipose Progenitor Cells, Adipocytes and Adipose Tissue

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 498

Special Issue Editor

Dr. Christian Dani

E-Mail Website
Guest Editor
Institut de Biologie Valrose, Université Côte d'Azur, CNRS 7277, Inserm U1091, Nice, France
Interests: human adipose tissue-derived stem cells; human iPSC-derived stem cells; stem cell culture; obesity stem cell therapy
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Given the global epidemic of obesity, there is increasing interest in adipose tissue and adipocyte biology. Three types of adipocytes, i.e., white, brown and beige/brite,  play key roles in energy homeostasis. This Special Issue focuses on the cellular biology aspect of adipose progenitor cells and adipocytes subpopulations, as well as on adipose tissue microenvironment, aims to unravel novel molecular mechanisms underlying adipocyte functions.

We welcome reviews, original research articles, communications, and perspective articles on all aspects related to the molecular and cellular mechanisms of adipose tissue and adipocytes in health and disease. 

We look forward to receiving your manuscripts.

Dr. Christian Dani
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • adipose progenitor cells
  • adipocytes
  • sub populations
  • microenvironment

Published Papers (1 paper)

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Research

16 pages, 6770 KiB  
Article
The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs
by Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang and Di Liu
Cells 2024, 13(8), 709; https://doi.org/10.3390/cells13080709 - 19 Apr 2024
Viewed by 353
Abstract
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic [...] Read more.
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic receptors (ADRBs) in pigs has been a topic of debate. To address this, we developed overexpression vectors for ADRB1, ADRB2, and ADRB3 and silenced the expression of these receptors to observe their effects on the adipogenic differentiation stages of porcine preadipocytes. Our investigation revealed that cold stress triggers the transformation of subcutaneous white adipose tissue to beige adipose tissue in pigs by modulating adrenergic receptor levels. Meanwhile, we found that ADRB3 promotes the transformation of white adipocytes into beige adipocytes. Notably, ADRB3 enhances the expression of beige adipose tissue marker genes, consequently influencing cellular respiration and metabolism by regulating lipolysis and mitochondrial expression. Therefore, ADRB3 may serve as a pivotal gene in animal husbandry and contribute to the improvement of cold intolerance in piglets. Full article
(This article belongs to the Special Issue Cellular Biology Research in Adipose Progenitor Cells, Adipocytes and Adipose Tissue)
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