Cellular Biology Research in Adipose Progenitor Cells, Adipocytes and Adipose Tissue

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cellular Metabolism".

Deadline for manuscript submissions: closed (15 March 2024) | Viewed by 1485

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Guest Editor
Institut de Biologie Valrose, Université Côte d'Azur, CNRS 7277, Inserm U1091, Nice, France
Interests: human adipose tissue-derived stem cells; human iPSC-derived stem cells; stem cell culture; obesity stem cell therapy
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Special Issue Information

Dear Colleagues,

Given the global epidemic of obesity, there is increasing interest in adipose tissue and adipocyte biology. Three types of adipocytes, i.e., white, brown and beige/brite,  play key roles in energy homeostasis. This Special Issue focuses on the cellular biology aspect of adipose progenitor cells and adipocytes subpopulations, as well as on adipose tissue microenvironment, aims to unravel novel molecular mechanisms underlying adipocyte functions.

We welcome reviews, original research articles, communications, and perspective articles on all aspects related to the molecular and cellular mechanisms of adipose tissue and adipocytes in health and disease. 

We look forward to receiving your manuscripts.

Dr. Christian Dani
Guest Editor

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Keywords

  • adipose progenitor cells
  • adipocytes
  • sub populations
  • microenvironment

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Published Papers (1 paper)

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Research

16 pages, 6770 KiB  
Article
The Role of β3-Adrenergic Receptors in Cold-Induced Beige Adipocyte Production in Pigs
by Shuo Yang, Hong Ma, Liang Wang, Fang Wang, Jiqiao Xia, Dongyu Liu, Linlin Mu, Xiuqin Yang and Di Liu
Cells 2024, 13(8), 709; https://doi.org/10.3390/cells13080709 - 19 Apr 2024
Cited by 1 | Viewed by 1231
Abstract
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic [...] Read more.
After exposure to cold stress, animals enhance the production of beige adipocytes and expedite thermogenesis, leading to improved metabolic health. Although brown adipose tissue in rodents is primarily induced by β3-adrenergic receptor (ADRB3) stimulation, the activation of major β-adrenergic receptors (ADRBs) in pigs has been a topic of debate. To address this, we developed overexpression vectors for ADRB1, ADRB2, and ADRB3 and silenced the expression of these receptors to observe their effects on the adipogenic differentiation stages of porcine preadipocytes. Our investigation revealed that cold stress triggers the transformation of subcutaneous white adipose tissue to beige adipose tissue in pigs by modulating adrenergic receptor levels. Meanwhile, we found that ADRB3 promotes the transformation of white adipocytes into beige adipocytes. Notably, ADRB3 enhances the expression of beige adipose tissue marker genes, consequently influencing cellular respiration and metabolism by regulating lipolysis and mitochondrial expression. Therefore, ADRB3 may serve as a pivotal gene in animal husbandry and contribute to the improvement of cold intolerance in piglets. Full article
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