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Cells
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Ageing and Neurodegenerative Diseases
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Ageing and Neurodegenerative Diseases

A special issue of Cells (ISSN 2073-4409). This special issue belongs to the section "Cells of the Nervous System".

Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 1011

Special Issue Editors

Dr. Feng Wang

E-Mail Website1 Website2
Guest Editor
Department of Human Genetics, Emory University School of Medicine, Atlanta, GA, USA
Interests: non-coding RNA (miRNAs, circRNAs); age-related neurodegenerative diseases (Alzheimer’s disease); epigenetics (5hmc, 5mc, 6mA)
Dr. Antonella Caccamo

E-Mail Website
Guest Editor
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy
Interests: Alzheimer's disease; neurodegeneration; mTOR; necroptosis; transgenic mice

Special Issue Information

Dear Colleagues,

AD and diabetes are two age-related diseases, and some studies have shown patients with diabetes to have an increasing risk of developing AD compared with those without the disease. For example, type 2 diabetes (T2D) patients observed to have reduced volumes of grey matter, white matter, hippocampus, and whole brain compared with healthy individuals. Although it was found that impaired insulin signaling is a key component of AD pathology and a hallmark of diabetes, the mechanistic pathway that links diabetes and AD is still not fully understood.

This Special Issue will accept original articles and reviews in the field of neurodegenerative disease. It also welcomes studies investigating age-related diseases’ complex interactions, potential disease biomarkers, and novel drug therapies. Manuscripts focusing on the noncoding RNAs in neurodegenerative disease and the underlying biological mechanisms are particularly sought-after.

Dr. Feng Wang
Dr. Antonella Caccamo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Cells is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • ageing
  • miRNAs
  • lncRNA
  • circRNAs
  • diabetes
  • neurodegenerative disease
  • insulin signaling

Published Papers (1 paper)

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Review

23 pages, 2334 KiB  
Review
CD4+ T-Cell Senescence in Neurodegenerative Disease: Pathogenesis and Potential Therapeutic Targets
by Yan Gao, Yaoping Lu, Xiaojing Liang, Mengwei Zhao, Xinyue Yu, Haiying Fu and Wei Yang
Cells 2024, 13(9), 749; https://doi.org/10.3390/cells13090749 - 25 Apr 2024
Viewed by 414
Abstract
With the increasing proportion of the aging population, neurodegenerative diseases have become one of the major health issues in society. Neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neurodegeneration [...] Read more.
With the increasing proportion of the aging population, neurodegenerative diseases have become one of the major health issues in society. Neurodegenerative diseases (NDs), including multiple sclerosis (MS), Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS), are characterized by progressive neurodegeneration associated with aging, leading to a gradual decline in cognitive, emotional, and motor functions in patients. The process of aging is a normal physiological process in human life and is accompanied by the aging of the immune system, which is known as immunosenescence. T-cells are an important part of the immune system, and their senescence is the main feature of immunosenescence. The appearance of senescent T-cells has been shown to potentially lead to chronic inflammation and tissue damage, with some studies indicating a direct link between T-cell senescence, inflammation, and neuronal damage. The role of these subsets with different functions in NDs is still under debate. A growing body of evidence suggests that in people with a ND, there is a prevalence of CD4+ T-cell subsets exhibiting characteristics that are linked to senescence. This underscores the significance of CD4+ T-cells in NDs. In this review, we summarize the classification and function of CD4+ T-cell subpopulations, the characteristics of CD4+ T-cell senescence, the potential roles of these cells in animal models and human studies of NDs, and therapeutic strategies targeting CD4+ T-cell senescence. Full article
(This article belongs to the Special Issue Ageing and Neurodegenerative Diseases)
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