Biomarker Diagnostics in Alzheimer’s Disease

Dear Colleagues,

Alzheimer’s disease (AD) is a chronic and debilitating neurodegenerative disease that is characterized and diagnosed clinically by progressive cognitive decline. It is well established that the pathophysiology of AD remains clinically silent for decades prior to symptomatic decline. Identifying individuals at risk of disease progression could allow for effective intervention whilst the therapeutic window remains open for preservation of quality of life. To this end, establishing biomarkers of AD can be essential in obtaining a specific molecular signature for each disease stage. Equally important is the need to develop improved diagnostic tests to interrogate biological samples for accurate detection of these disease-specific markers at an early stage and differentiate AD from other forms of dementia.

This Special Issue of Cells aims to introduce new concepts which can enhance our current understanding of AD-specific biomarkers and provide a comprehensive update on recent advances in specific techniques/scientific discoveries that can be instrumental in the early diagnosis and monitoring of disease progression. Original articles and comprehensive reviews which cover topics including candidate biomarker identification in Alzheimer’s disease, novel diagnostic methods using easily accessible biofluids, investigation of biochemical changes in the brain through imaging studies, and development of specific tests tracking AD progression are welcome.

Dr. Charles R. Harrington
Prof. Claude M. Wischik
Dr. Mohammad Arastoo
Dr. Soumya Palliyil
Guest Editors

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