Dear Colleagues,

Embryonic development is a fascinating process requiring a very precise spatiotemporal regulation of cellular proliferation and subsequent differentiation. There are a few model systems addressing experimentally these issues and the vertebrate limb development is one of the more popular ones. This model makes it possible not only to study the embryonic events but also to investigate pathological and repair processes in postnatal life.

All major signaling pathways are activated during the induction, progression, and regeneration of the vertebrate limb. Most cellular processes such as migration, patterning, differentiation are also present. Several types of stem cells have been described, which are present during limb development.

Importantly, the limb is very plastic and the bewildering variety of shapes and sizes only attests to that. This plasticity is also seen in the paleontological record.

Last, but not least, the vertebrate limb preserved the ability to fully regenerate in salamanders.

While the histological and morphological events are well described, their molecular and cellular basis remain only partially discovered.

This Special Issue will focus on the latest developments in limb induction, regeneration, and patterning with the particular focus on the cellular and molecular aspects of those processes.

Prof. Przemko Tylzanowski
Guest Editor

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• limb induction
• limb regeneration
• limb patterning
• chondrogenesis
• osteogenesis
• myogenesis
• stem cells